Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    Human Identical Sequences of SARS-CoV-2 Promote Clinical Progression of COVID-19 MESHD by Upregulating Hyaluronan via NamiRNA-Enhancer Network

    Authors: Wei Li; Shuai Yang; Peng Xu; Dapeng Zhang; Ying Tong; Lu Chen; Ben Jia; Ang Li; Daoping Ru; Baolong Zhang; Mengxing Liu; Cheng Lian; Cancan Chen; Weihui Fu; Songhua Yuan; Xiaoguang Ren; Ying Liang; Zhicong Yang; Wenxuan Li; Shaoxuan Wang; Xiaoyan Zhang; Hongzhou Lu; Jianqing Xu; Hailing Wang; Wenqiang Yu; Vattipally B Sreenu; Jay Nix; Ruth F Jarrett; Martina Beltramello; Kyriaki Nomikou; Matteo Pizzuto; Lily Tong; Elisabetta Cameroni; Natasha Johnson; Arthur Wickenhagen; Alessandro Ceschi; Daniel Mair; Paolo Ferrari; Katherine Smollett; Federica Sallusto; Stephen Carmichael; Christian Garzoni; Jenna Nichols; Massimo Galli; Joseph Hughes; Agostino Riva; Antonia Ho; Peter JM Openshaw; Kenneth Baillie; - The ISARIC4C Investigators; - COVID-19 Genomics UK (COG-UK) consortium; Suzannah J Rihn; Samantha J Lycett; Herbert W Virgin; Amalio Telenti; Davide Corti; David L Robertson; Gyorgy Snell; Lingxiao Wang; Lisa White; Pan Xu; Yupeng Yang; Osman N Yogurtcu; Weitong Zhang; Yanting Zhao; Difan Zou; Matthew Ferrari; David Pannell; Michael Tildesley; Jack Seifarth; Elyse Johnson; Matthew Biggerstaff; Michael Johansson; Rachel B Slayton; John Levander; Jeff Stazer; Jessica Salermo; Michael C Runge

    doi:10.1101/2020.11.04.361576 Date: 2020-11-05 Source: bioRxiv

    The COVID-19 MESHD COVID-19 MESHD pandemic is a widespread and deadly public health crisis. The pathogen SARS-CoV-2 replicates in the lower respiratory tract and causes fatal pneumonia MESHD. Although tremendous efforts have been put into investigating the pathogeny of SARS-CoV-2, the underlying mechanism of how SARS-CoV-2 interacts with its host is largely unexplored. Here, by comparing the genomic sequences of SARS-CoV-2 and human, we identified five fully conserved elements in SARS-CoV-2 genome, which were termed as "human identical sequences ( HIS MESHD)". HIS MESHD are also recognized in both SARS-CoV MESHD and MERS-CoV genome. Meanwhile, HIS-SARS-CoV-2 are highly conserved in the primate. Mechanically, HIS-SARS-CoV-2 RNA directly binds to the targeted loci in human genome and further interacts with host enhancers to activate the expression of adjacent and distant genes, including cytokines gene and angiotensin converting enzyme II ( ACE2 HGNC), a well-known cell entry receptor of SARS-CoV-2, and hyaluronan synthase 2 HGNC ( HAS2 HGNC), which further increases hyaluronan formation. Noteworthily, hyaluronan level in plasma of COVID-19 MESHD patients is tightly correlated with severity and high risk for acute respiratory distress syndrome MESHD ( ARDS MESHD) and may act as a predictor for the progression of COVID-19 MESHD. HIS antagomirs, which downregulate hyaluronan level effectively, and 4-Methylumbelliferone (MU), an inhibitor of hyaluronan synthesis, are potential drugs to relieve the ARDS MESHD related ground-glass pattern in lung for COVID-19 MESHD treatment. Our results revealed that unprecedented HIS elements of SARS-CoV-2 contribute to the cytokine storm and ARDS MESHD in COVID-19 MESHD patients. Thus, blocking HIS-involved activating processes or hyaluronan synthesis directly by 4-MU may be effective strategies to alleviate COVID-19 MESHD progression.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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