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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Dysregulation in mTOR HGNC/ HIF-1 HGNC signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells

    Authors: Sofia Appelberg; Soham Gupta; Anoop T Ambikan; Flora Mikaeloff; Akos Vegvari; Sara Svensson Akusjarvi; Rui Benfeitas; Maike Sperk; Marie Stahlberg; Shuba Krishnan; Kamal Singh; Josef M Penninger; Ali Mirazimi; Ujjwal Neogi

    doi:10.1101/2020.04.30.070383 Date: 2020-05-01 Source: bioRxiv

    How Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) infections MESHD engage cellular host pathways and innate immunity in infected cells remain largely elusive. We performed an integrative proteo-transcriptomics analysis in SARS-CoV-2 infected MESHD HuH7 cells to map the cellular response to the invading virus over time. We identified four pathways, ErbB HGNC, HIF-1 HGNC, mTOR HGNC and TNF signaling, among others that were markedly modulated during the course of the SARS-CoV-2 infection MESHD in vitro. Western blot validation of the downstream effector molecules of these pathways revealed a significant reduction in activated S6K1 and 4E-BP1 at 72 hours post infection. Unlike other human respiratory viruses, we found a significant inhibition of HIF-1 HGNC through the entire time course of the infection, suggesting a crosstalk between the SARS-CoV-2 and the mTOR HGNC/ HIF-1 HGNC signaling. Further investigations are required to better understand the molecular sequelae in order to guide potential therapy in the management of severe COVID-19 MESHD patients.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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