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HGNC Genes

SARS-CoV-2 proteins

ORF8 (2)

ProteinS (2)


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    The Discovery of a Recombinant SARS2-like CoV Strain Provides Insight Into SARS and COVID-19 MESHD Pandemics

    Authors: Xin Li; Xiufeng Jin; Shunmei Chen; Liangge Wang; Tung On Yau; Jianyi Yang; Zhangyong Hong; Jishou Ruan; Guangyou Duan; Shan Gao

    doi:10.21203/rs.3.rs-60430/v1 Date: 2020-08-16 Source: ResearchSquare

    Background: In December 2019, the world awoke to a new zoonotic strain of coronavirus named severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2).Results: In the present study, we classified betacoronavirus subgroup B into the SARS-CoV-2, SARS-CoV MESHD and SARS-like CoV clusters, and the ORF8 PROTEIN genes of these three clusters into types 1, 2 and 3, respectively. One important result of our study is that we reported—for the first time—a recombination event of ORF8 PROTEIN at the whole-gene level in a bat, which had been co-infected MESHD by two betacoronavirus strains. This result provides substantial proof for long-existing hypotheses regarding the recombination and biological functions of ORF8 PROTEIN. Based on the analysis of recombination events in the Spike gene, we propose that the Spike protein PROTEIN of SARS-CoV-2 may have more than one specific receptor for its function as gp120 HGNC of HIV has CD4 HGNC and CCR5 HGNC. In the present study, we also found that the ancestor of betacoronavirus had a strong first Internal Ribosome Entry Site (IRES) and at least one furin cleavage site (FCS) in the junction region between S1 and S2 subunits.Conclusions: We concluded that the junction FCS in SARS-CoV-2 may increase the efficiency of its entry into cells, while the type 2 ORF8 PROTEIN acquired by SARS-CoV may increase its replication efficiency. These two most critical events provide the most likely explanation for SARS and COVID-19 pandemic MESHD COVID-19 pandemic MESHDs.

    The discovery of a recombinant SARS2-like CoV strain provides insights into SARS and COVID-2019 pandemics

    Authors: Xin Li; Xiufeng Jin; Shunmei Chen; Liangge Wang; Tung On Yau; Jianyi Yang; Zhangyong Hong; Jishou Ruan; Guangyou Duan; Shan Gao

    doi:10.1101/2020.07.22.213926 Date: 2020-07-22 Source: bioRxiv

    In December 2019, the world awoke to a new zoonotic strain of coronavirus named severe acute respiratory syndrome coronavirus-2 MESHD (SARS-CoV-2). In the present study, we classified betacoronavirus subgroup B into the SARS-CoV-2, SARS-CoV MESHD and SARS-like CoV clusters, and the ORF8 PROTEIN genes of these three clusters into types 1, 2 and 3, respectively. One important result of our study is that the recently reported strain RmYN02 was identified as a recombinant SARS2-like CoV strain that belongs to the SARS-CoV-2 cluster MESHD, but has an ORF8 PROTEIN from a SARS-like CoV. This result provides substantial proof for long-existing hypotheses regarding the recombination and biological functions of ORF8 PROTEIN. Based on the analysis of recombination events in the Spike gene, we propose that the Spike protein PROTEIN of SARS-CoV-2 may have more than one specific receptor for its function as gp120 HGNC of HIV has CD4 HGNC and CCR5 HGNC. We concluded that the furin protease cleavage site acquired by SARS-CoV-2 may increase the efficiency of viral entry into cells, while the type 2 ORF8 PROTEIN acquired by SARS-CoV may increase its replication efficiency. These two most critical events provide the most likely explanation for SARS and COVID-2019 pandemics.

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MeSH Disease
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