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SARS-CoV-2 proteins

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    New insights into n COVID-19 MESHD binding domain and its cellular receptors

    Authors: Ankush Garg; Gaurav Kumar; Sharmistha Sinha; Kiersten P Tucker; Karen Lin; Mario Cortese; Sean Tucker; Maribel Huaringa Nunez; Nancy Rojas Serrano; Omar Caceres Rey

    doi:10.1101/2020.09.06.285023 Date: 2020-09-06 Source: bioRxiv

    n COVID-19 MESHD virus makes cellular entry using its spike protein PROTEIN protruding out on its surface. Angiotensin converting enzyme 2 receptor has been identified as a receptor that mediates the viral entry by binding with the receptor binding motif of spike protein PROTEIN. In the present study, we elucidate the significance of N-terminal domain of spike protein PROTEIN in spike-receptor interactions. Recent clinical reports indicate a link between n COVID-19 MESHD infections with patient comorbidities. The underlying reason behind this relationship is not clear. Using molecular docking, we study the affinity of the n COVID-19 MESHD spike protein PROTEIN with cell receptors overexpressed under disease conditions. Our results suggest that certain cell receptors such as DC/L-SIGN, DPP4 HGNC, IL22R HGNC and ephrin receptors could act as potential receptors for the spike protein PROTEIN. The receptor binding domain of n COVID-19 MESHD is more flexible than that of SARS-COV MESHD and has a high propensity to undergo phase separation. Higher flexibility of n COVID-19 MESHD receptor binding domain might enable it to bind multiple receptor partners. Further experimental work on the association of these receptors with spike protein PROTEIN may help us to explain the severity of n COVID-19 MESHD infection in patients with comorbidities.

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MeSH Disease
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SARS-CoV-2 Proteins


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