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SARS-CoV-2 proteins

ProteinE (1)


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    SARS-COV2 Envelope Protein (E PROTEIN) interacts with the Lysophosphatidic Acid Receptor 1 HGNC ( LPAR1 HGNC) from humans

    Authors: GIRISH NALLUR

    doi:10.21203/rs.3.rs-42592/v1 Date: 2020-07-13 Source: ResearchSquare

    A proteomic screen of human proteins interacting with the SARS-COV2 Envelope (E) protein PROTEIN identified LPAR1 HGNC as a strong candidate. Physical association of E protein PROTEIN and LPAR1 HGNC was confirmed by co-immunoprecipitation and cell surface staining. LPAR1 HGNC- E protein PROTEIN interaction was confirmed in all eight human cell lines tested. Many additional proteins participating in the E protein PROTEIN interactions network were also enriched from each of the cell lines, some of which were cell type specific. These findings suggest that LPAR1 HGNC is likely a cell surface receptor for the E protein PROTEIN, and pave the way for follow-on studies aimed at understanding the biological significance of the interactions in SARS-COV disease MESHD, including the signaling mechanisms.

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MeSH Disease
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