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SARS-CoV-2 proteins

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    Highly pathogenic coronavirus N protein PROTEIN aggravates lung injury by MASP-2 HGNC-mediated complement over-activation

    Authors: Ting Gao; Mingdong Hu; Xiaopeng Zhang; Hongzhen Li; Lin Zhu; Hainan Liu; Qincai Dong; Zhang Zhang; Zhongyi Wang; Yong Hu; Yangbo Fu; Yanwen Jin; Kaitong Li; Songtao Zhao; Yongjiu Xiao; Shuping Luo; Lufeng Li; Lingfang Zhao; Junli Liu; Huailong Zhao; Yue Liu; Weihong Yang; Jing Peng; Xiaoyu Chen; Ping Li; Yaoning Liu; Yonghong Xie; Jibo Song; Lu Zhang; Qingjun Ma; Xiuwu Bian; Wei Chen; Xuan Liu; Qing Mao; Cheng Cao

    doi:10.1101/2020.03.29.20041962 Date: 2020-03-30 Source: medRxiv

    An excessive immune response contributes to SARS-CoV, MERS-CoV and SARS-CoV-2 pathogenesis MESHD and lethality, but the mechanism remains unclear. In this study, the N proteins PROTEIN of SARS-CoV MESHD, MERS-CoV and SARS-CoV-2 were found to bind to MASP-2 HGNC, the key serine protease in the lectin pathway of complement activation, resulting in aberrant complement activation and aggravated inflammatory lung injury MESHD. Either blocking the N protein PROTEIN: MASP-2 HGNC interaction or suppressing complement activation can significantly alleviate N protein PROTEIN-induced complement hyper-activation MESHD and lung injury MESHD in vitro and in vivo. Complement hyper-activation MESHD was also observed in COVID-19 MESHD patients, and a promising suppressive effect was observed when the deteriorating patients were treated with anti-C5a monoclonal antibody. Complement suppression MESHD may represent a common therapeutic approach for pneumonia MESHD induced by these highly pathogenic coronaviruses.

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