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SARS-CoV-2 proteins

ProteinE (1)


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    Enhanced binding of SARS-CoV-2 Envelope protein PROTEIN to tight junction-associated PALS1 HGNC could play a key role in COVID-19 MESHD pathogenesis

    Authors: Flavio De Maio; Ettore Lo Cascio; Gabriele Babini; Michela Sali; Stefano Della Longa; Bruno Tilocca; Paola Roncada; Alessandro Arcovito; Maurizio Sanguinetti; Giovanni Scambia; Andrea Urbani

    doi:10.21203/rs.3.rs-30903/v1 Date: 2020-05-21 Source: ResearchSquare

    Background: The Envelope (E) protein PROTEIN of SARS-CoV-2 is the most enigmatic protein among the four structural ones on the viral genome. Most of the current knowledge on the E protein PROTEIN is based on the direct comparison to the SARS E protein PROTEIN, initially mistakenly undervalued and subsequently proved to be a key factor in the ER-Golgi localization and in tight junction disruption. Methods: We compared the genomic sequences of E protein PROTEIN of SARS-CoV-2, SARS-CoV MESHD and the closely related genomes of bats and pangolins obtained from the GISAID and GenBank databases. Multiple sequence alignments were done with the Geneious software using the MAFFT algorithm. In silico modelling analyses of E proteins PROTEIN conformation and docking with PALS1 HGNC were performed with the Schrodinger Suite.Results: When compared to the known SARS E protein PROTEIN, we observed a different amino acidic sequence in the C-terminal of SARS-CoV-2 E protein PROTEIN which might have a key role in the current COVID-19 MESHD pathogenesis. In silico docking results provide evidence of a strengthened binding of SARS-CoV-2 E protein PROTEIN with the tight junction-associated PALS1 HGNC protein.Conclusions: We suggest that SARS-CoV-2 E protein PROTEIN may interfere with the tight junction stability and formation leading to an enhanced epithelial barrier disruption, amplifying the inflammatory processes, and promoting tissue remodelling. These findings raise a warning on the underestimated role of the E protein PROTEIN in the pathogenic mechanism and could open the route to detailed experimental investigations. 

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MeSH Disease
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