Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    The potential role of miR-21-3p HGNC in coronavirus-host interplay

    Authors: Stepan Nersisyan; Narek Engibaryan; Aleksandra Gorbonos; Ksenia Kirdey; Alexey Makhonin; Alexander Tonevitsky

    doi:10.1101/2020.07.03.184846 Date: 2020-07-04 Source: bioRxiv

    ABSTRACTHost miRNAs are known as important regulators of virus replication and pathogenesis. They can interact with various viruses by several possible mechanisms including direct binding the viral RNA. Identification of human miRNAs involved in coronavirus-host interplay is becoming important due to the ongoing COVID-19 MESHD COVID-19 MESHD pandemic. In this work we performed computational prediction of high-confidence direct interactions between miRNAs and seven human coronavirus RNAs. In order to uncover the entire miRNA-virus interplay we further analyzed lungs miRNome of SARS-CoV infected MESHD mice using publicly available miRNA sequencing data. We found that miRNA miR-21-3p HGNC has the largest probability of binding the human coronavirus RNAs and being dramatically up-regulated in mouse lungs during infection induced by SARS-CoV MESHD. Further bioinformatic analysis of binding sites revealed high conservativity of miR-21-3 HGNCp binding regions within RNAs of human coronaviruses and their strains.Competing Interest StatementThe authors have declared no competing interest.View Full Text

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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