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SARS-CoV-2 proteins

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    Comparative analyses of SAR-CoV2 genomes from different geographical locations and other coronavirus family genomes reveals unique features potentially consequential to host-virus interaction and pathogenesis

    Authors: Rahila Sardar; Deepshikha Satish; Shweta Birla; Dinesh Gupta

    doi:10.1101/2020.03.21.001586 Date: 2020-03-21 Source: bioRxiv

    The ongoing pandemic of the coronavirus disease 2019 MESHD ( COVID-19 MESHD) is an infectious disease MESHD caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV2). We have performed an integrated sequence-based analysis of SARS-CoV2 genomes from different geographical locations in order to identify its unique features absent in SARS-CoV MESHD and other related coronavirus family genomes, conferring unique infection, facilitation of transmission, virulence and immunogenic features to the virus. The phylogeny of the genomes yields some interesting results. Systematic gene level mutational analysis of the genomes has enabled us to identify several unique features of the SARS-CoV2 genome, which includes a unique mutation in the spike surface glycoprotein (A930V (24351C>T)) in the Indian SARS-CoV2, absent in other strains studied here. We have also predicted the impact of the mutations in the spike glycoprotein PROTEIN function and stability, using computational approach. To gain further insights into host responses to viral infection MESHD, we predict that antiviral host-miRNAs may be controlling the viral pathogenesis. Our analysis reveals nine host miRNAs which can potentially target SARS-CoV2 genes. Interestingly, the nine miRNAs do not have targets in SARS and MERS genomes. Also, hsa- miR-27b HGNC is the only unique miRNA which has a target gene in the Indian SARS-CoV2 genome. We also predicted immune epitopes in the genomes

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MeSH Disease
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SARS-CoV-2 Proteins


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