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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Cyclooxgenase-2 is induced by SARS-CoV-2 infection MESHD but does not affect viral entry or replication

    Authors: Jennifer S. Chen; Mia Madel Alfajaro; Jin Wei; Ryan D. Chow; Renata B Filler; Stephanie C. Eisenbarth; Craig B Wilen; Li Hui Tan; Beihua Dong; Konstantinos Dionysios Alysandratose; Jesse Huang; James N Palmer; Nithin D Adappa; Michael A Kohanski; Darrell N Kotton; Robert H Silverman; Wenli Yang; Edward Morrisey; Noam Cohen; Susan R Weiss; David C. Jackson; Nathan W Bartlett; Francesca Mercuri; Miles W Carroll; Sonam T. Nyatsatsang; Alexander L. Greninger; Ansuman T. Satpathy; John S Pauk; Scott D. Boyd; James R. Heath

    doi:10.1101/2020.09.24.312769 Date: 2020-09-25 Source: bioRxiv

    Identifying drugs that regulate severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD and its symptoms has been a pressing area of investigation during the coronavirus disease 2019 MESHD ( COVID-19 MESHD) pandemic. Nonsteroidal anti-inflammatory drugs (NSAIDs), which are frequently used for the relief of pain MESHD and inflammation MESHD, could modulate both SARS-CoV-2 infection MESHD and the host response to the virus. NSAIDs inhibit the enzymes cyclooxygenase-1 HGNC ( COX-1 HGNC) and cyclooxygenase-2 HGNC ( COX-2 HGNC), which mediate the production of prostaglandins (PGs). PGE2, one of the most abundant PGs, has diverse biological roles in homeostasis and inflammatory responses. Previous studies have shown that NSAID treatment or inhibition of PGE2 receptor signaling leads to upregulation of angiotensin-converting enzyme 2 HGNC ( ACE2 HGNC), the cell entry receptor for SARS-CoV-2, thus raising concerns that NSAIDs could increase susceptibility to infection. COX/PGE2 signaling has also been shown to regulate the replication of many viruses, but it is not yet known whether it plays a role in SARS-CoV-2 replication. The purpose of this study was to dissect the effect of NSAIDs on COVID-19 MESHD in terms of SARS-CoV-2 entry MESHD and replication. We found that SARS-CoV-2 infection MESHD induced COX-2 HGNC upregulation in diverse human cell culture and mouse systems. However, suppression of COX-2/PGE2 signaling by two commonly used NSAIDs, ibuprofen and meloxicam, had no effect on ACE2 HGNC expression, viral entry, or viral replication. Our findings suggest that COX-2 HGNC signaling driven by SARS-CoV-2 may instead play a role in regulating the lung inflammation MESHD and injury observed in COVID-19 MESHD patients.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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