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SARS-CoV-2 proteins

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    The Association of 25 (OH) Vitamin D Levels and Severity and Outcome of COVID-19 MESHD: A Cross-sectional Study

    Authors: Maryam Vasheghani; Nasrin Jannati; Parvaneh Baghaei; Mitra Rezaei; Majid Marjani

    doi:10.21203/rs.3.rs-141034/v1 Date: 2021-01-05 Source: ResearchSquare

    Background Coronavirus disease 2019 MESHD ( COVID-19 MESHD) is a pandemic disease. Experiments with influenza and severe acute respiratory syndrome MESHD (SARS) have shown supplemental vitamin D can reduce the risk of infection and death MESHD.AimThis study was performed to evaluate the relationship between vitamin D levels and the severity and outcome of admitted patients with COVID-19 MESHD.Material and MethodsThis cross-sectional study was performed on COVID-19 MESHD cases diagnosed by examining RT-PCR assay for SARS-CoV-2 or a set of symptoms and typical findings in lung CT scan. Based on clinical and radiologic characteristics, the patients were categorized as mild, moderate, severe, and critical. Calcium, phosphorus, albumin, creatinine, and serum 25 hydroxy vitamin D were measured and their correlation with the severity and outcome were analyzed.ResultsFrom May 1 HGNC to June 31, 2020, 508 patients ((442 patients in general wards and 66 patients in intensive care unit (ICU)) were included in this study. The participants were 56±17 years old (mean ±SD) (range from 14 to 95 years) and 52% were male. According to the past medical history, 190 (37.4%) of them had comorbidity. Concerning severity, 13.2%, 42.3%, 35.4%, and 9.1% had the mild, moderate, severe, and critical disease, respectively. The in-hospital mortality rate was 10.8%. In the multivariate regression analysis, age had a positive correlation and use of vitamin D supplement, serum level of 25 OH vitamin D, calcium, and albumin had a negative correlation with disease severity and admission to ICU. Poor outcome was inversely related to serum levels of vitamin D, calcium, albumin, and renal function. Vitamin D deficiency increased the rate of ICU admission by 2.7 times (95%CI=1.288-5.91, P=0.009).ConclusionIn patients who are hospitalized due to COVID-19 MESHD, low 25-hydroxyvitamin D, hypocalcemia, and hypoalbuminemia are associated with severe disease, ICU admission, and an increase in mortality.

    On the heterogeneity of infections, containment measures and the preliminary forecast of COVID-19 MESHD epidemic

    Authors: Ichiro Nakamoto; Weiqing Zhuang; Sheng Wang; Yan Guo

    doi:10.1101/2020.05.12.20096792 Date: 2020-05-18 Source: medRxiv

    As of May 1 HGNC, 2020, there had been over three million of officially confirmed cases of novel coronavirus ( COVID-19 MESHD) infections reported worldwide. The pandemic originated from a severe acute respiratory syndrome coronavirus 2 (SARSCoV-2), a virus similar to severe acute respiratory syndrome MESHD (SARS). The dynamics of the pathogen incurred the incidence of the unidentified cases that were potentially substantial in magnitude. Unparalleled extensive measures, either in terms of medical quarantine or non-medical containment, were taken to deplete the growth of infected population and thereafter settle down the outbreak. We aimed to estimate the gap in sizes and peak dates between the confirmed and unconfirmed, and how containment measures impacted the dynamic trajectory of the COVID-19 MESHD in Japan. We performed simulations and desired to provide meaningful insight for the upcoming responses to the outbreak, for which much still remained to be unknown.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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