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SARS-CoV-2 proteins

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    The Spike Protein S1 PROTEIN Subunit of SARS-CoV-2 Contains an LxxIxE-like Motif that is Known to Recruit the Host PP2A-B56 Phosphatase

    Authors: Halim Maaroufi

    doi:10.1101/2020.04.01.020941 Date: 2020-04-03 Source: bioRxiv

    SARS-CoV-2 is highly contagious and can cause acute respiratory distress syndrome MESHD ( ARDS MESHD) and multiple organ failure MESHD that are largely attributed to the cytokine storm. The surface coronavirus spike ( S) glycoprotein PROTEIN is considered as a key factor in host specificity because it mediates infection by receptor-recognition and membrane fusion. Here, the analysis of SARS-CoV-2 S protein PROTEIN revealed two B56-binding LxxIxE-like motifs in S1 and S2 subunits that could recruit the host protein phosphatase 2A ( PP2A HGNC). The motif in S1 subunit is absent in SARS-CoV MESHD and MERS-CoV. Phosphatases and kinases are major players in the regulation of pro-inflammatory responses during pathogenic infections. Moreover, studies have shown that viruses target PP2A HGNC in order to manipulate hosts antiviral responses. Recent researches have indicated that SARS-CoV-2 is involved in sustained host inflammation MESHD. Therefore, by controlling acute inflammation MESHD, it is possible to eliminate its dangerous effects on the host. Among efforts to fight COVID-19 MESHD, the interaction between LxxIxE-like motif and the PP2A-B56-binding pocket could be a target for the discovery and/or development of a bioactive ligand inhibitor for therapeutic purposes. Indeed, a small molecule called Artepillin C (ArtC), a main compound in Brazilian honeybee green propolis, mimics the side chains of LxxLxE motif. Importantly, ArtC is known, among other effects, to have anti-inflammatory activity that makes it an excellent candidate for future clinical trials in COVID-19 MESHD patients.

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MeSH Disease
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