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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    SARS-CoV-2 infection MESHD in primary schools in northern France: A retrospective cohort study in an area of high transmission

    Authors: Arnaud Fontanet; Rebecca Grant; Laura Tondeur; Yoann Madec; Ludivine Grzelak; Isabelle Cailleau; Marie-Noelle Ungeheuer; Charlotte Renaudat; Sandrine Fernandes Pellerin; Lucie Kuhmel; Isabelle Staropoli; Francois Anna; Pierre Charneau; Caroline Demeret; Timothee Bruel; Olivier Schwartz; Bruno Hoen

    doi:10.1101/2020.06.25.20140178 Date: 2020-06-29 Source: medRxiv

    Background: The extent of SARS-CoV-2 transmission among pupils in primary schools and their families is unknown. Methods: Between 28-30 April 2020, a retrospective cohort study was conducted among pupils, their parents and relatives, and staff of primary schools exposed to SARS-CoV-2 in February and March 2020 in a city north of Paris, France. Participants completed a questionnaire that covered sociodemographic information and history of recent symptoms. A blood sample was tested for the presence of anti-SARS-CoV-2 antibodies using a flow-cytometry-based assay. Results: The infection attack rate ( IAR HGNC) was 45/510 (8.8%), 3/42 (7.1%), 1/28 (3.6%), 76/641 (11.9%) and 14/119 (11.8%) among primary school pupils, teachers, non-teaching staff, parents, and relatives, respectively (P = 0.29). Prior to school closure on February 14, three SARS-CoV-2 infected pupils MESHD attended three separate schools with no secondary cases in the following 14 days among pupils, teachers and non-teaching staff of the same schools. Familial clustering of cases was documented by the high proportion of antibodies among parents and relatives of infected pupils MESHD (36/59 = 61.0% and 4/9 = 44.4%, respectively). In children, disease manifestations were mild, and 24/58 (41.4%) of infected children were asymptomatic. Interpretation: In young children, SARS-CoV-2 infection MESHD was largely mild or asymptomatic and there was no evidence of onwards transmission from children in the school setting.

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MeSH Disease
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SARS-CoV-2 Proteins


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