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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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SARS-CoV-2 Proteins
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    A contact tracing prospective cohort retrieving epidemiological facts on SARS-CoV-2 transmission aspects; a serological analysis 

    Authors: Reza Vazirinejad; Parvin Khalili; Abdollah Jafarzadeh; Ziba Shabani; Ahmad Jamalizadeh; Batool Rezaei; Hassan Ahmadnia; Mohammad-taghi Rezayati; Mohammad Ebrahimian; Gholamreza Mehralinasab; Azam Bagherizadeh; Shima Bazaz; Erfan Vazirinejad

    doi:10.21203/rs.3.rs-121829/v1 Date: 2020-12-04 Source: ResearchSquare

    Introduction Novel coronavirus spread seems mysterious enough for convincing us to double check the indices being used to predict its transmission. Serological analysis was applied for assessing some metric epidemiological aspects of the i nfection MESHDand its transmissibility among people who were in contact with S ARA- HGNCCoV-2 patients.   Methods In this contact tracing prospective cohort study, 453 contact cases of forty COVID 19 patients were followed for three months.  SARS-CoV-2 patients were diagnosed by real time polymerase chain reaction testing of nasopharyngeal samples. The history of infectiousness was detected by serological testing of IgG and IgM. Trained expert team completed two questionnaires and blood samples were taken by experts in laboratory. Data were analyzed using SPSS (Ver.21) and R software. Some important epidemiological characteristics of the i nfection MESHDwere calculated. Results Mean age of S ARS-CoV-2 MESHDpatients and contact cases were 53.0±18.2 and 30.8±19.3 years, respectively. Overall R0 of the i nfection MESHDwas 2.56. Household and non-household secondary attack rates (S AR) HGNC were 20% (95%CI; 12.7 – 27.3) and 11.3% (95%CI; 6.1-16.5), respectively. Transmission probability in each contact was 0.0205 and the serial interval was 6.4±4.6 (95% CI; 5.2–7.6) days. S AR HGNCamong contact cases who exposed asymptomatic primary cases (28%, 95%CI; 10-46%) was higher than that (13.8%, 95%CI;9.4-18.2) among contact cases exposing to symptomatic patients. Conclusions We concluded a herd immunity between 60 and 65% is needed in human communities. Findings demonstrated how much reduction in i nfection MESHDR0 is predicted based on both clinical and public health interventions. 

    Household transmission of SARS-CoV-2: a systematic review and meta-analysis of secondary attack rate

    Authors: Zachary J. Madewell; Yang Yang; Ira M. Longini Jr.; M. Elizabeth Halloran; Natalie E. Dean

    doi:10.1101/2020.07.29.20164590 Date: 2020-08-01 Source: medRxiv

    Background: Severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) is spread by direct, indirect, or close contact with infected people via infected respiratory droplets MESHD or saliva. Crowded indoor environments with sustained close contact and conversations are a particularly high-risk setting. Methods: We performed a meta-analysis through July 29, 2020 of SARS-CoV-2 household secondary attack rate ( SAR HGNC), disaggregating by several covariates (contact type, symptom status, adult/child contacts, contact sex, relationship to index case, index case sex, number of contacts in household, coronavirus). Findings: We identified 40 relevant published studies that report household secondary transmission. The estimated overall household SAR HGNC was 18.8% (95% confidence interval [CI]: 15.4%-22.2%), which is higher than previously observed SARs for SARS-CoV MESHD and MERS-CoV. We observed that household SARs were significantly higher from symptomatic index cases than asymptomatic index cases, to adult contacts than children contacts, to spouses than other family contacts, and in households with one contact than households with three or more contacts. Interpretation: To prevent the spread of SARS-CoV-2, people are being asked to stay at home worldwide. With suspected or confirmed infections referred to isolate at home, household transmission will continue to be a significant source of transmission.

    First Case Of SAR HGNC-Coronavirus-2 Sequencing In The Cerebrospinal Fluid Of A Patient With Suspected CNS Demyelinating Disease

    Authors: Renan Domingues; Maria Cássia Mendes-Correa; Fernando Brunale Vilela de Moura Leite; Ester Cerdeira Sabino; Ingra M Claro; Noely Evangelista Ferreira; Camila Malta Romano; Jaqueline Goes de Jesus; Daniel Wagner de Castro Lima Santos; Diego Zanotti Salarini; Carlos Senne

    doi:10.21203/rs.3.rs-31801/v1 Date: 2020-05-26 Source: ResearchSquare

    The association between coronaviruses and central nervous system (CNS) demyelinating lesions MESHD has been previously shown. However, no case has been described of an association between the novel coronavirus (SARS-COV-2) and CNS demyelinating disease MESHD so far. SARS-COV-2 was previously detected in cerebrospinal fluid (CSF) sample of a patient with encephalitis MESHD. However, the virus identity was not confirmed by deep sequencing of SARS-COV-2 detected in the CSF. Here, we report a case of a patient with mild respiratory symptoms MESHD and neurological manifestations compatible with Clinically Isolated Syndrome. The viral genome of SARS-COV-2 was detected and sequenced in CSF with 99.74 to 100% similarity between the patient virus and worldwide sequences. This report suggests a possible association of SARS COV-2 infection MESHD with neurological symptoms of demyelinating disease MESHD, even in the absence of relevant upper respiratory tract infection MESHD signs.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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