Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    High-dimensional profiling reveals phenotypic heterogeneity and disease-specific alterations of granulocytes in COVID-19 MESHD

    Authors: Magda Lourda; Majda Dzidic; Laura Hertwig; Helena Bergsten; Laura M Palma Medina; Egle Kvedaraite; Jagadeeswara Rao Muvva; Jean-Baptiste Gorin; Martin Cornillet; Johanna Emgard; Kirsten Moll; Marina Garcia; Kimia T Maleki; Jonas Klingstrom; Jakob Michaelsson; Malin Flodstrom-Tullberg; Susanna Brighenti; Marcus Buggert; Jenny Mjosberg; Karl-Johan Malmberg; Johan K Sandberg; Jan-Inge Henter; Elin Folkesson; Sara Gredmark-Russ; Anders Sonnerborg; Lars I Eriksson; Olav Rooyackers; Soo Aleman; Kristoffer Stralin; Hans-Gustaf Ljunggren; Niklas K Bjorkstrom; Mattias Svensson; Andrea Ponzetta; Anna Norrby-Teglund; Benedict J Chambers; - Karolinska KI/K COVID-19 Study Group

    doi:10.1101/2021.01.27.21250591 Date: 2021-01-31 Source: medRxiv

    Since the outset of the COVID-19 pandemic MESHD, increasing evidence suggests that the innate immune responses play an important role in the disease development. A dysregulated inflammatory state has been proposed as key driver of clinical complications in COVID-19 MESHD, with a potential detrimental role of granulocytes. However, a comprehensive phenotypic description of circulating granulocytes in SARS-CoV-2-infected MESHD patients is lacking. In this study, we used high-dimensional flow cytometry for granulocyte immunophenotyping in peripheral blood collected from COVID-19 MESHD patients during acute and convalescent phases. Severe COVID-19 MESHD was associated with increased levels of both mature and immature neutrophils, and decreased counts of eosinophils and basophils. Distinct immunotypes were evident in COVID-19 MESHD patients, with altered expression of several receptors involved in activation, adhesion and migration of granulocytes (e.g. CD62L HGNC, CD11a HGNC/b, CD69 HGNC, CD63 HGNC, CXCR4 HGNC). Paired sampling revealed recovery and phenotypic restoration of the granulocytic signature in the convalescent phase. The identified granulocyte immunotypes correlated with distinct sets of soluble inflammatory markers supporting pathophysiologic relevance. Furthermore, clinical features, including multi-organ dysfunction MESHD and respiratory function, could be predicted using combined laboratory measurements and immunophenotyping. This study provides a comprehensive granulocyte characterization in COVID-19 MESHD and reveals specific immunotypes with potential predictive value for key clinical features associated with COVID-19 MESHD. SignificanceAccumulating evidence shows that granulocytes are key modulators of the immune response to SARS-CoV-2 infection MESHD and their dysregulation MESHD could significantly impact COVID-19 MESHD severity and patient recovery after virus clearance. In the present study, we identify selected immune traits in neutrophil, eosinophil and basophil subsets associated to severity of COVID-19 MESHD and to peripheral protein profiles. Moreover, computational modeling indicates that the combined use of phenotypic data and laboratory measurements can effectively predict key clinical outcomes in COVID-19 MESHD patients. Finally, patient-matched longitudinal analysis shows phenotypic normalization of granulocyte subsets 4 months after hospitalization. Overall, in this work we extend the current understanding of the distinct contribution of granulocyte subsets to COVID-19 MESHD pathogenesis.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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