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HGNC Genes

SARS-CoV-2 proteins

ProteinS (1)


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    PSGL-1 HGNC blocks SARS-CoV-2 S protein PROTEIN-mediated virus attachment and infection of target cells

    Authors: Sijia He; Abdul A. Waheed; Brian Hetrick; Deemah Dabbagh; Ivan V. Akhrymuk; Kylene Kehn-Hall; Eric O. Freed; Yuntao Wu

    doi:10.1101/2020.05.01.073387 Date: 2020-05-02 Source: bioRxiv

    P-selectin glycoprotein ligand-1 HGNC ( PSGL-1 HGNC) is a cell surface glycoprotein that binds to P-, E-, and L-selectins to mediate the tethering and rolling of immune cells on the surface of the endothelium for cell migration into inflamed tissues. PSGL-1 HGNC has been identified as an interferon-γ (INF-γ)-regulated factor that restricts HIV-1 infectivity MESHD, and has recently been found to possess broad-spectrum antiviral activities. Here we report that the expression of PSGL-1 HGNC in virus-producing cells impairs the incorporation of SARS-CoV and SARS-CoV-2 spike MESHD SARS-CoV-2 spike PROTEIN ( S) glycoproteins PROTEIN into pseudovirions and blocks virus attachment MESHD and infection of target cells. These findings suggest that PSGL-1 HGNC may potentially inhibit coronavirus replication in PSGL-1 HGNC+ cells.Competing Interest StatementThe authors have declared no competing interest.View Full Text

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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