Corpus overview


MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

There are no SARS-CoV-2 protein terms in the subcorpus


SARS-CoV-2 Proteins
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    Selenium Deficiency is Associated with Mortality Risk from COVID-19 MESHD

    Authors: Arash Moghaddam; Raban Arved Heller; Qian Sun; Julian Seelig; Asan Cherkezov; Linda Seibert; Julian Hackler; Petra Seemann; Joachim Diegmann; Maximilian Pilz; Manuel Bachmann; Waldemar B. Minich; Lutz Schomburg

    id:10.20944/preprints202007.0113.v1 Date: 2020-07-07 Source:

    SARS-CoV-2 infections MESHD underlie the current Coronavirus disease MESHD ( COVID-19 MESHD) pandemic and are causative for a high death toll particularly among elderly subjects and those with comorbidities. Selenium (Se) is an essential trace element of high importance for human health and particularly for a well-balanced immune response. Mortality risk from severe disease like sepsis MESHD or polytrauma MESHD is inversely related to Se status. We hypothesized that this relation also applies to COVID-19 MESHD. Serum samples (n=166) from COVID-19 MESHD patients (n=33) were collected consecutively and analysed for total Se by X-ray fluorescence and selenoprotein P HGNC ( SELENOP HGNC) by a validated ELISA. Both biomarkers showed the expected strong correlation (r=0.7758, p<0.001), pointing to an insufficient Se status for optimal selenoprotein expression. In comparison to reference data from a European cross sectional analysis (EPIC, n=1915), the patients showed a pronounced deficit in total serum Se (mean±SD, 50.8±15.7 vs. 84.4±23.4 µg/L) and SELENOP HGNC (3.0±1.4 vs. 4.3±1.0 mg/L). A Se status below the 2.5th percentile of the reference population, i.e., [Se] < 45.7 µg/L and [ SELENOP HGNC] < 2.56 mg/L was present in 43.4% and 39.2% of COVID samples, respectively. The Se status was significantly higher in samples from surviving COVID patients as compared to non-survivors (Se; 53.3±16.2 vs. 40.8±8.1 µg/L, SELENOP HGNC; 3.3±1.3 vs. 2.1±0.9 mg/L). We conclude that Se status analysis in COVID patients provides diagnostic information. However, causality remains unknown due to the observational nature of this study. Nevertheless, the findings strengthen the notion on a relevant role of Se for COVID convalescence, and support the discussion on adjuvant Se supplementation in severely diseased and Se-deficient patients.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins

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