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SARS-CoV-2 proteins

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    Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection MESHD and disease in mice

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    doi:10.1101/2021.03.01.433110 Date: 2021-03-01 Source: bioRxiv

    Despite the introduction of public health measures and spike protein PROTEIN-based vaccines to mitigate the COVID-19 pandemic MESHD, SARS-CoV-2 infections MESHD SARS-CoV-2 infections MESHD and deaths continue to rise. Previously, we used a structural design approach to develop picomolar range miniproteins targeting the SARS-CoV-2 receptor binding domain. Here, we investigated the capacity of modified versions of one lead binder, LCB1 HGNC, to protect against SARS-CoV-2-mediated lung disease MESHD in human ACE2 HGNC-expressing transgenic mice. Systemic administration of LCB1-Fc reduced viral burden, diminished immune cell infiltration and inflammation MESHD, and completely prevented lung disease MESHD and pathology. A single intranasal dose of LCB1v1.3 reduced SARS-CoV-2 infection MESHD in the lung even when given as many as five days before or two days after virus inoculation. Importantly, LCB1v1.3 protected in vivo against a historical strain (WA1/2020), an emerging B.1.1.7 strain, and a strain encoding key E484K and N501Y spike protein PROTEIN substitutions. These data support development of LCB1v1.3 for prevention or treatment of SARS-CoV-2 infection MESHD.

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MeSH Disease
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SARS-CoV-2 Proteins


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