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HGNC Genes

SARS-CoV-2 proteins

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    Identification of potential coagulation pathway abnormalities in SARS-Cov-2 infection MESHD SARS-Cov-2 infection MESHD; insights from bioinformatics analysis

    Authors: Sareh Arjmand; Nazanin Hosseinkhan; Nagarjuna R Cheermarla; James Knight; Ellen Foxman; Antonio Giraldez; Peidong Shen; Kaya Bilguvar; Curt Scharfe; Catherine Polling; Sharon A.M. Stevelink; Reza Razavi; Matthew Hotopf; - KCL-CHECK research team; Kirk C Hansen; Tellen D Bennett; Elena W.Y. Hsieh; Joaquin M Espinosa

    doi:10.1101/2020.12.07.414631 Date: 2020-12-07 Source: bioRxiv

    Abnormal coagulation MESHD parameters have been explored in a significant number of severe COVID-19 MESHD patients, linked to poor prognosis and increased risk of organ failure MESHD. Here, to uncover the potential abnormalities in coagulation pathways, we analyzed the RNA-seq data (GEO147507) obtained from the treatment of three pulmonary epithelial cell lines with SARS-CoV-2. The significant differentially expressed genes ( DEGs HGNC) were subjected to Enrichr database for KEGG pathway enrichment analysis and gene ontology (GO) functional annotation. The STRING database was used to generate PPI networks for identified DEGs HGNC. We found three upregulated procoagulant genes ( SERPINE1 HGNC, SERPINA5 HGNC, and SERPINB2 HGNC) belong to the serine protease inhibitor (serpin) superfamily that inhibit tissue plasminogen activator (t-PA HGNC) and urokinase plasminogen activator ( u-PA HGNC) in the fibrinolysis process. In conclusion, we suggest the fibrinolysis process, especially the blockage of t-PA HGNC and u-PA HGNC inhibitors, a potential target for more study in treating coagulopathy MESHD in severe COVID-19 MESHD cases.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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