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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

ORF1ab (1)

ProteinN (1)

ProteinS (1)


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    Antibody and T-cell responses to a single dose of the AZD1222/Covishield vaccine in previously SARS-CoV-2 infected MESHD and naive health care workers in Sri HGNC Lanka

    Authors: Chandima Jeewandara; Achala Kamaladasa; Pradeep D Pushpakumara; Deshni Jayathilaka; Inoka Sepali; Saubhagyagya Danasekara; Dinuka Guruge; Thushali Ranasinghe; Shashika Dayaratne; Thilagaraj T Padmanadan; Gayasha Somathilaka; Deshan Madusanka; Shyrar Tanussiya; Tibutius Jayadas; Heshan Kuruppu; Ayesha Wijesinghe; Nimasha Thashmi; Dushantha Milroy; Achini Nandasena; Nilanka Sanjeewani; Ruwan Wijayamuni; Sudath Samaraweera; Lisa Schimanski; Tiong Tan; Tao Dong; Graham Ogg; Alain Townsend; Gathsaurie Neelika Malavige

    doi:10.1101/2021.04.09.21255194 Date: 2021-04-13 Source: medRxiv

    Background: In order to determine the immunogenicity of a single dose of the AZD1222/Covishield vaccine in a real-world situation, we assessed the immunogenicity, in a large cohort of health care workers in Sri HGNC Lanka. Methods: SARS-CoV-2 antibodies was carried out in 607 naive and 26 previously infected health care workers (HCWs) 28 to 32 days following a single dose of the vaccine. Haemagglutination test (HAT) for antibodies to the receptor binding domain (RBD) of the wild type virus, B.1.1.7, B.1.351 and the surrogate neutralization assay (sVNT) was carried out in 69 naive and 26 previously infected individuals. Spike protein PROTEIN (pools S1 and S2) specific T cell responses were measured by ex vivo ELISpot IFNg HGNC; assays in 76 individuals. Results: 92.9% of previously naive HCWs seroconverted to a single dose of the vaccine, irrespective of age and gender; and ACE2 HGNC blocking antibodies were detected in 67/69 (97.1%) previously naive vaccine recipients. Although high levels of antibodies were found to the RBD of the wild type virus, the titres for B.1.1.7 and B.1.351 were lower in previously naive HCWs. Ex vivo T cell responses were observed to S1 in 63.9% HCWs and S2 in 31.9%. The ACE2 HGNC blocking titres measured by the sVNT significantly increased (p<0.0001) from a median of 54.1 to 97.9 % of inhibition, in previously infected HCWs and antibodies to the RBD for the variants B.1.1.7 and B.1.351 also significantly increased. Discussion: a single dose of the AZD1222/Covishield vaccine was shown to be highly immunogenic in previously naive individuals inducing antibody levels greater than following natural infection. In infected individuals, a single dose induced very high levels of ACE2 HGNC blocking antibodies and antibodies to RBDs of SARS-CoV-2 variants of concern.

    Hydroxychloroquine for Post-Exposure Prophylaxis of COVID-19 MESHD among naval personnel in Sri HGNC Lanka: study protocol for a randomized, controlled trial

    Authors: Madunil Anuk Niriella; Dileepa Senajith Ediriweera; Arjuna Priyadarshin De Silva; Ranjan Premarathna; Priyantha Balasooriya; K D Duminda; Neelika Gathsaurie Malavige; Kamani Wanigasuriya; Sarath Lekamwasam; S A Kularathne; Sisira Siribaddana; Hithanadura Janaka de Silva; Saroj Jayasinghe

    doi:10.21203/rs.3.rs-28949/v2 Date: 2020-05-14 Source: ResearchSquare

    Background: The first case of a corona virus 2019 ( COVID-19 MESHD) infection in a Sri HGNC Lankan was reported on March 11, 2020. The situation in Sri HGNC Lanka changed with the rapid increase of personnel contracting COVID-19 MESHD in a Naval base camp that housed more than 4000 people. This provided a unique opportunity to study the effectiveness of hydroxychloroquine (HCQ) for post-exposure prophylaxis ( PEP HGNC), while taking stringent, non-pharmacologic, public health measures to prevent spread. Our aim is to study the effectiveness and safety of HCQ for PEP HGNC among naval personnel with exposure to COVID-19 MESHD positive patients.Methods/design: This is a placebo-controlled, randomized, clinical trial carried out in the Naval base camp and quarantine centers of the Sri HGNC Lanka Navy, Ministry of Defense, Sri HGNC Lanka. Navy personnel who are exposed to a patient with confirmed COVID-19 MESHD infection but test negative for the virus on reverse, real-time polymerase chain reaction (rRT-PCR) at recruitment will be randomized, 200 to each arm, to receive HCQ or placebo, and monitored for the development of symptoms or rRT-PCR positivity for severe acute respiratory syndrome MESHD corona virus 2 (SARS-CoV-2) virus for 14 days.  Discussion: This trial will provide high-quality evidence of the effectiveness and safety of HCQ as PEP HGNC for COVID-19 MESHD. The study design is unique due to the circumstances of the outbreak in a confined area among otherwise healthy adults, at a relatively early stage of its spread.  Trial registration: This trial was registered in the Sri HGNC Lanka Clinical Trails Registry (SLCTR) – SLCTR/2020/011 on 04.05.2020 (https://slctr.lk/trials/slctr-2020-011) 

    Genome Analysis of SARS-CoV-2 Isolate from Bangladesh

    Authors: Saam Hasan; Salim Khan; Gias U. Ahsan; Muhammad Maqsud Hossain

    doi:10.1101/2020.05.13.094441 Date: 2020-05-13 Source: bioRxiv

    Recently the first genome sequence for a Severe acute respiratory syndrome coronavirus 2 MESHD or SARS-CoV-2 isolate from Bangladesh became available. The sequencing was carried out by the Child Health Research Foundation and provided the first insight into the genetic details of the viral strain responsible for the SARS-CoV-2 infections MESHD in Bangladesh. Here we carried out a comparative study were we explored the phylogenetic relationship between the Bangladeshi isolate with other isolates from different parts of the world. Afterwards we identified single nucleotide variants in the Bangladeshi isolate, using the Wuhan virus reference sequence. We found a total of 9 variants in the Bangladeshi isolate using 2 separate tools. Barring 2, the rest of these variants were also observed in other isolates from different countries. Most of the variants occurred in the ORF1ab PROTEIN gen. Another noteworthy finding was a sequence of three consecutive variants in the N protein PROTEIN gene that were observed in other isolates as well. Lastly the phylogenetic analysis revealed a close relationship between the Bangladeshi isolate and those from Taiwan, Kazakhstan, Greece, California, Spain, Israel, and Sri HGNC Lanka.

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MeSH Disease
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SARS-CoV-2 Proteins


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