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MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

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    Profiling pre-symptomatic and asymptomatic cases with confirmed SARS-CoV-2 infection MESHD in Mexico City

    Authors: Omar Yaxmehen Bello-Chavolla; Neftali Eduardo Antonio-Villa; Arsenio Vargas-Vázquez; Carlos A. Fermín-Martínez; Alejandro Márquez-Salinas; Jessica Paola Bahena-López

    doi:10.1101/2020.07.02.20145516 Date: 2020-07-04 Source: medRxiv

    BACKGROUND: Asymptomatic SARS-CoV-2 infections MESHD SARS-CoV-2 infections MESHD are potential sources for transmission. OBJECTIVES: Here, we aimed to profile pre-symptomatic/asymptomatic SARS-CoV-2 infections MESHD in Mexico City, its associated comorbidities and outcomes. METHODS: Prospective observational study of SARS-CoV-2 cases assessed by contact tracing within the National Epidemiological Surveillance System in Mexico City. We classified subjects as cases with and without respiratory and non-respiratory symptoms (RS, NRS HGNC, respectively) assessed for SARS-CoV-2 using real time RT-PCR from nasopharyngeal swabs to evaluate clinical characteristics as well as features associated with severe COVID-19 MESHD. RESULTS: Amongst 80735 cases with confirmed SARS-CoV-2 infection MESHD as of July 23th, 2020, we identified 9659 cases without RS (12.0%), 5605 had only NRS HGNC (6.9%) and 4054 who were initially asymptomatic (5.1%). Compared to asymptomatic cases, those with NRS HGNC and those with RS+ NRS HGNC had higher rates of severe COVID-19 MESHD outcomes including hospitalization, ICU admission, and intubation (p<0.001). Mortality was higher for cases with RS+ NRS HGNC (HR 7.58, 95%CI 4.56-12.58) or NRS HGNC (HR 3.13, 95%CI 1.80-5.45) compared to asymptomatic cases, adjusted for age, sex and comorbidities. Predictors for mortality in asymptomatic SARS-Co-V-2 infections MESHD, chronic kidney disease MESHD, previous exposure with suspected infection cases and older age were predictors for lethality. CONCLUSIONS: Definition of pre-symptomatic/asymptomatic cases has relevant implications for SARS-CoV-2 infection MESHD outcomes. Older age and comorbidity impact on the probability of developing severe complications for cases who were asymptomatic or had only NRS HGNC at evaluation and were sent for domiciliary treatment. Extending testing for detection of asymptomatic cases must be considered in Mexico to better understand the impact of the pandemic.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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