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SARS-CoV-2 proteins

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    Quantitative proteomics of hamster lung tissues infected with SARS-CoV-2 reveal host-factors having implication in the disease pathogenesis and severity

    Authors: Voddu Suresh; Varshasnata Mohanty; Kiran Avula; Arup Ghosh; Bharti Singh; R Rajendra Kumar Reddy; Amol Ratnakar Suryawanshi; Sunil Raghav; Soma Chattopadhyay; Punit Prasad; Rajeeb Kumar Swain; Rupesh Dash; Ajay Parida; Gulam Hussain Syed; Shantibhusan Senapati

    doi:10.1101/2021.03.09.434371 Date: 2021-03-09 Source: bioRxiv

    Syrian golden hamsters (Mesocricetus auratus) infected MESHD by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) manifests lung pathology that resembles human COVID-19 MESHD patients. In this study, efforts were made to check the infectivity of a local SARS-CoV-2 isolate in hamster model and evaluate the differential expression of lung proteins during acute infection MESHD and convalescence. The findings of this study confirm the infectivity of this isolate in vivo. Analysis of clinical parameters and tissue samples shows a similar type of pathophysiological manifestation of SARS-CoV-2 infection MESHD as reported earlier in COVID-19 MESHD patients and hamsters infected with other isolates. The lung-associated pathological changes were very prominent on the 4th day post-infection (dpi), mostly resolved by 14dpi. Here, we carried out quantitative proteomic analysis of the lung tissues from SARS-CoV-2-infected MESHD hamsters at day 4 and day 14 post infection. This resulted in the identification of 1,585 differentially expressed proteins of which 68 proteins were significantly altered among both the infected groups. Pathway analysis revealed complement and coagulation cascade, platelet activation, ferroptosis and focal adhesion as the top enriched pathways. In addition, we also identified altered expression of two pulmonary surfactant-associated proteins ( Sftpd HGNC and Sftpb HGNC), known for their protective role in lung function. Together, these findings will aid in the identification of candidate biomarkers and understanding the mechanism(s) involved in SARS-CoV-2 pathogenesis.

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MeSH Disease
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SARS-CoV-2 Proteins


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