Corpus overview


Overview

MeSH Disease

HGNC Genes

SARS-CoV-2 proteins

Filter

Genes
Diseases
SARS-CoV-2 Proteins
    displaying 1 - 1 records in total 1
    records per page




    Potential activity of a selected natural compounds on SARS-CoV-2 RNA-dependent-RNA polymerase PROTEIN, and binding affinity of the receptor-binding domain (RBD)

    Authors: Hisham Altayeb; Lamjed Bouslama; Jawaher Abdualbaqi Abdulhakimc; Kamel Chaieb; Othman A. S. Baothman; Mazin A. Zamzami

    doi:10.21203/rs.3.rs-32971/v1 Date: 2020-06-02 Source: ResearchSquare

    Coronavirus disease MESHD ( COVID-19 MESHD) is caused by SARS-CoV-2 and represents the causative agent of a potentially lethal disease. COVID-19 MESHD has been described as a significant global public health pandemic by the World Health Organization due to its high mortality rate, rapid spread, and the lack of drugs and vaccines for it. Active antiviral drugs are desperately needed to combat the potential return of severe acute respiratory syndrome MESHD (SARS).In this study, we selected 39 natural compounds present in plants, algae, and sponges with antiviral activity. Molecular docking was used to screen the compounds’ activity on SARS- CoV-2 RNA-dependent-RNA polymerase PROTEIN, receptor-binding domain (RBD), and the human ACE2 receptor. Compounds with binding energy ≤ -6.5 kcal/mol enter pre-clinical testing using in silco ADME/ Tox HGNC (absorption, distribution, metabolism, excretion, and toxicity MESHD).We found eight potential SARS-CoV-2 inhibitors: (glycyrrhizin, rutin, baicalin, 1, 6-di-O- galloyl-beta-D-glucose, pyropheophorbide A, pheophorbide A, beta-Sitosterol, and vitexin). These outcomes indicate that these compounds could be potential candidates to be utilized in lead optimization for the design and production of the anti-SARS-CoV-2 drug.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.