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HGNC Genes

SARS-CoV-2 proteins

ORF7a (1)


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    Potential impact on coagulopathy of gene variants of coagulation related proteins that interact with SARS-CoV-2

    Authors: David Holcomb; Aikaterini Alexaki; Nancy Hernandez; Kyle Laurie; Jacob Kames; Nobuko Hamasaki-Katagiri; Anton A. Komar; Michael DiCuccio; Chava Kimchi-Sarfaty; Gyan Ranjan; Beena Philomina Jose; Rajendran Vadukkoot Raman; Thulaseedharan Nallaveettil Kesavan; Kalpana George; Sheela Mathew; Jayesh Kumar Poovullathil; Sajeeth Kumar Keeriyatt Govindan; Priyanka Raveendranadhan Nair; Shameer Vadekkandiyil; Vineeth Gladson; Midhun Mohan; Fairoz Cheriyalingal Parambath; Mohit Mangla; Afra Shamnath; Sridhar Sivasubbu; Vinod Scaria

    doi:10.1101/2020.09.08.272328 Date: 2020-09-09 Source: bioRxiv

    Thrombosis has been one of the complications of the Coronavirus disease of 2019 ( COVID-19 MESHD), often associated with poor prognosis. There is a well-recognized link between coagulation and inflammation MESHD, however, the extent of thrombotic MESHD events associated with COVID-19 MESHD warrants further investigation. Poly(A) Binding Protein Cytoplasmic 4 HGNC ( PABPC4 HGNC), Serine/Cysteine Proteinase Inhibitor Clade G Member 1 HGNC ( SERPING1 HGNC) and Vitamin K epOxide Reductase Complex subunit 1 HGNC ( VKORC1 HGNC), which are all proteins linked to coagulation, have been shown to interact with SARS proteins. We computationally examined the interaction of these with SARS-CoV-2 proteins MESHD and, in the case of VKORC1 HGNC, we describe its binding to ORF7a PROTEIN in detail. We examined the occurrence of variants of each of these proteins across populations and interrogated their potential contribution to COVID-19 MESHD severity. Potential mechanisms by which some of these variants may contribute to disease are proposed. Some of these variants are prevalent in minority groups that are disproportionally affected by severe COVID-19 MESHD. Therefore, we are proposing that further investigation around these variants may lead to better understanding of disease pathogenesis in minority groups and more informed therapeutic approaches.

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MeSH Disease
HGNC Genes
SARS-CoV-2 Proteins


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