Corpus overview


Overview

MeSH Disease

Hypertension (13)

Disease (8)

Infections (8)

Cough (7)

Fever (7)


Human Phenotype

Transmission

Seroprevalence
    displaying 1 - 10 records in total 13
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    Characterization of the SARS-CoV-2 outbreak in the State of Qatar, February 28-April 18, 2020

    Authors: Hanan M Al Kuwari; Hanan F Abdul Rahim; Laith J Abu Raddad; Abdul-Badi Abou-Samra; Zaina Al Kanaani; Abdullatif Al Khal; Einas Al Kuwari; Salih Al Marri; Muna Al Masalmani; Hamad Eid Al Romaihi; Sheikh M Al Thani; Peter Coyle; Ali N Latif; Robert Owen; Roberto Bertollini; Adeel A Butt

    doi:10.1101/2020.07.15.20154211 Date: 2020-07-16 Source: medRxiv

    Objective To define the epidemiologic curve of COVID-19 in Qatar, determine factors associated with severe or critical illness MESHD, and study the temporal relation between public health measures and case finding Design Epidemiologic investigation Setting and Participants All confirmed COVID-19 cases in the State of Qatar between February 28 and April 18, 2020 Main Outcome Measures Number of total and daily new COVID-19 infections MESHD; demographic characteristics and comorbidity burden and severity of infection MESHD; factors associated with severe or critical illness MESHD Results Between February 28 and April 18, 2020 (11:00AM local time), 5,685 cases of COVID-19 were identified. Mean age TRANS (SD) was 35.8(12.0) years, 88.9% were male TRANS and 8.7% were Qatari nationals. Overall, 83.6% had no concomitant comorbidity, and 3.0% had 3 or more comorbidities. The overwhelming majority (90.9%) were asymptomatic TRANS or with minimal symptoms, with 2.0% having severe or critical illness MESHD. Presence of hypertension MESHD hypertension HP or diabetes were associated with a higher risk of severe or critical illness MESHD. Seven deaths MESHD were observed during the time interval studied. The epidemiologic curve indicated two distinct patterns of infection MESHD, a larger cluster among expatriate craft and manual workers, and a smaller one among Qatari nationals returning from abroad during the epidemic. Conclusion COVID-19 infections MESHD in Qatar started in two distinct clusters, but then became more widespread in the population through community transmission TRANS. Infections were mostly asymptomatic MESHD asymptomatic TRANS or with minimal symptoms and associated with very low mortality. Severe/ critical illness MESHD was associated with presence of hypertension MESHD hypertension HP or diabetes.

    Placental SARS-CoV-2 in a patient with mild COVID-19 disease MESHD

    Authors: Albert L. Hsu; Minhui Guan; Eric Johannesen; Amanda J. Stephens; Nabila Khaleel; Nikki Kagan; Breanna C. Tuhlei; Xiu-Feng Wan

    doi:10.1101/2020.07.11.20149344 Date: 2020-07-14 Source: medRxiv

    Background: The full impact of COVID-19 on pregnancy remains uncharacterized. Current literature suggests minimal maternal, fetal, and neonatal morbidity and mortality,1 and COVID-19 manifestations appear similar between pregnant and non-pregnant women.2 We present a case of placental SARS-CoV-2 virus in a woman with an uncomplicated pregnancy and mild COVID-19 disease MESHD. Methods: A pregnant woman was evaluated at University of Missouri Women and Childrens Hospital. Institutional review board approval was obtained; information was obtained from medical records. Reverse transcriptase-polymerase chain reaction (RT-PCR) was performed to detect SARS-CoV-2. A gynecological pathologist examined the placenta and performed histolopathology. Sections were formalin-fixed and paraffin-embedded; slides were cut and subjected to hematoxylin-and-eosin or immunohistochemistry (IHC) staining. IHC was performed with specific monoclonal antibodies SERO to detect SARS-CoV-2 antigen or to identify trophoblasts. Findings: A 29 year-old multigravida presented at 40-4/7 weeks for labor induction. With myalgias MESHD myalgias HP two days prior, she tested positive for SARS-CoV-2. Her parents TRANS were in self-isolation for COVID-19 positivity; husband was asymptomatic TRANS and tested negative for COVID-19, but exposed to a workplace (meatpacking facility) outbreak. Prenatal course was uncomplicated, with no gestational hypertension MESHD hypertension HP. She was afebrile and asymptomatic TRANS with normal vital signs throughout hospitalization. Her myalgias MESHD myalgias HP improved prior to admission. A liveborn male TRANS infant was delivered vaginally. Newborn course was uneventful; he was appropriate for gestational age TRANS, physical was unremarkable, and he was discharged home at 36 hours. COVID-19 RT-PCR test was negative at 24 hours. At one-week follow-up, newborn was breastfeeding well, with no fevers MESHD fevers HP or respiratory distress HP. Overall placental histology is consistent with acute uterine hypoxia MESHD (subchorionic laminar necrosis MESHD) superimposed on chronic uterine hypoxia MESHD (extra-villous trophoblasts and focal chronic villitis). IHC using SARS-CoV-2 nucleocapsid-specific monoclonal antibody SERO demonstrated SARS-CoV-2 antigens throughout the placenta in chorionic villi endothelial cells, and rarely in CK7-expressing trophoblasts. Negative control placenta (November 2019 delivery) and ferret nasal turbinate tissues (not shown) were negative for SARS-CoV-2. Interpretation: In this report, SARS-CoV-2 was found in the placenta, but newborn was COVID-19 negative. Our case shows maternal vascular malperfusion, with no features of fetal vascular malperfusion. To our knowledge, this is the first report of placental COVID-19 despite mild COVID-19 disease MESHD in pregnancy (with no symptoms of COVID-19 aside from myalgias MESHD myalgias HP); specifically, this patient had no fever MESHD fever HP, cough MESHD cough HP, or shortness of breath, but only myalgias MESHD myalgias HP and sick contacts. Despite her having mild COVID-19 disease MESHD in pregnancy, we demonstrate placental vasculopathy and presence of SARS-CoV-2 virus across the placenta. Evidence of placental COVID-19 raises concern for possible placental vasculopathy (potentially leading to fetal growth restriction, pre-eclampsia MESHD eclampsia HP, and other pregnancy complications MESHD) as well as for potential vertical transmission TRANS -- especially for pregnant women who may be exposed to COVID-19 in early pregnancy. Further studies are urgently needed, to determine whether women with mild, pre-symptomatic, or asymptomatic TRANS COVID-19 may have SARS-CoV-2 virus that can cross the placenta, cause fetal vascular malperfusion, and possibly affect the fetus. This raises important public health and public policy questions of whether future pregnancy guidance should include stricter pandemic precautions, such as screening for a wider array of COVID-19 symptoms, increased antenatal surveillance, and possibly routine COVID-19 testing on a regular basis throughout pregnancy.

    Management of mild COVID-19: Policy implications of initial experience in India

    Authors: Rohit Kumar; bisakh bhattacharya; Ved Prakash Meena; Anivita Aggarwal; Manasi Tripathi; Manish Soneja; Ankit Mittal; Komal Singh; Nishkarsh Gupta; Rakesh Kumar Garg; Brajesh Ratre; Balbir Kumar; Shweta Bhopale; Pavan Tiwari; Ankit Verma; Sushma Bhatnagar; Anant Mohan; Naveet Wig; Randeep Guleria

    doi:10.1101/2020.05.20.20107664 Date: 2020-05-25 Source: medRxiv

    Objectives- Ongoing pandemic due to COVID-19 has spread across countries, surprisingly with variable clinical characteristics and outcomes. This study was aimed at describing clinical characteristics and outcomes of admitted patients with mild COVID-19 illness in the initial phase of pandemic in India. Design - Retrospective (observational ) study. Setting - COVID facilities under AIIMS, New Delhi, where, isolation facilities were designed to manage patients with mild illness and dedicated COVID ICUs was created to cater patients with moderate to severe illness. Participants - Patients aged TRANS 18 years or more, with confirmed illness were eligible for enrolment. Patients who were either asymptomatic TRANS or mildly ill at presentation were included. Patients with moderate to severe illness at admission, or incomplete clinical symptomatology records were excluded. Methods - Data regarding demographic profile, comorbidities, clinical features, hospital course, treatment, details of results of RT-PCR for SARS-CoV-2 done at baseline and at day 14, chest radiographs (wherever available) as well as laboratory parameters was obtained retrospectively from the hospital records. Main outcome measures - Final outcome was noted in terms of course of the disease MESHD, patients discharged, still admitted (at time of conclusion of study) or death MESHD. Results -Out of 231 cases included, majority were males TRANS(78.3%) with a mean age TRANS of 39.8 years. Comorbidities were present in 21.2% of patients, diabetes mellitus MESHD diabetes mellitus HP and hypertension MESHD hypertension HP being most common. The most common symptoms were dry cough MESHD cough HP(81, 35%), fever MESHD fever HP(64, 27.7%), sore throat(36, 15.6%), and dyspnoea(24, 10.4%); asymptomatic infection MESHD asymptomatic TRANS was noted in 108(46.8%) patients. Presence of comorbidities was an independent predictor of symptomatic disease MESHD (OR-2.66; 95% CI 1.8 to 6.53, p= 0.03). None of the patients progressed to moderate to severe COVID-19. There were no deaths MESHD in this cohort. Conclusions - Patients with mild disease MESHD at presentation had a stable disease MESHD course and therefore such cases can be managed outside hospital setting. A large proportion of patients remained asymptomatic TRANS throughout the course of infection MESHD and those with comorbidities are more likely to be symptomatic. Trial registration - Not applicable

    Risks to Children TRANS under-five in India from COVID-19

    Authors: Isabel Frost; Katie Tseng; Stephanie Hauck; Geetanjali Kappor; Aditi Sriram; Arindam Nandi; Ramanan Laxminarayan

    doi:10.1101/2020.05.18.20105239 Date: 2020-05-22 Source: medRxiv

    Objective: The novel coronavirus, COVID-19, has rapidly emerged to become a global pandemic and is known to cause a high risk to patients over the age TRANS of 70 and those with co-morbidities, such as hypertension MESHD hypertension HP and diabetes. Though children TRANS are at comparatively lower risk compared to adults TRANS, the Indian population has a large young demographic that is likely to be at higher risk due to exposure to pollution, malnutrition MESHD malnutrition HP and poor access to medical care. We aimed to quantify the potential impact of COVID-19 on Indias child TRANS population. Methods: We combined district family household survey data with data from the COVID-19 outbreak in China to analyze the potential impact of COVID-19 on children TRANS under the age TRANS of 5, under three different scenarios; each of which assumed the prevalence SERO of infection MESHD to be 0.5%, 1%, or 5%. Results: We find that in the lowest prevalence SERO scenario, across the most populous 18 Indian states, asymptomatic TRANS, non-hospitalized symptomatic and hospitalized symptomatic cases could reach 87,200, 412,900 and 31,900, respectively. In a moderate prevalence SERO scenario, these figures reach 174,500, 825,800, and 63,800, and in the worst case, high prevalence SERO scenario these cases could climb as high as 872,200, 4,128,900 and 319,700. Conclusion: These estimates show COVID-19 has the potential to pose a substantial threat to Indias large population of children TRANS, particularly those suffering from malnutrition MESHD malnutrition HP and exposure to indoor air pollution, who may have limited access to health services.

    Identifying baseline clinical features of people with COVID-19

    Authors: Daniela Ferreira-Santos; Priscila Maranhao; Matilde Monteiro-Soares

    doi:10.1101/2020.05.13.20100271 Date: 2020-05-16 Source: medRxiv

    Objectives: To describe baseline clinical characteristics of adult TRANS patients with COVID-19. Methods: We conducted a scoping review of the evidence available at LitCovid, until March 23th, 2020, and selected articles that reported the prevalence SERO of socio-demographic characteristics, symptoms and co-morbidities in adults TRANS with COVID-19. Results: In total, 1 572 publications were published on LitCovid. We have included 56 articles in our analysis, with 89% conducted in China, and 75% contained inpatients. Three studies were conducted in North America and one in Europe. Participants age TRANS ranged from 28 to 70 years, with balanced gender TRANS distribution. Proportion of asymptomatic TRANS cases were from 2 to 79%. The most common reported symptoms were fever MESHD fever HP [4-99%], cough MESHD cough HP [4-92%], dyspnoea/shortness of breath [1-90%], fatigue MESHD fatigue HP 4-89%], myalgia MESHD myalgia HP [3-65%], and pharyngalgia [2-61%], while regarding co-morbidities we found cardiovascular disease MESHD [1-40%], hypertension MESHD hypertension HP [0-40%] and cerebrovascular disease MESHD [1-40%]. Such heterogeneity impairs the conduction of meta-analysis. Conclusions: The infection MESHD by COVID-19 seems to affect people in a very diverse manner and with different characteristics. With the available data it is not possible to clearly identify those at higher risk of being infected with this condition. Furthermore, the evidence from countries other than China is, at the day, too scarce.

    The effects of ARBs, ACEIs and statins on clinical outcomes of COVID-19 infection MESHD among nursing home residents

    Authors: Anton De Spiegeleer; Antoon Bronselaer; James T Teo; Geert Byttebier; Guy De Tre; Luc Belmans; Richard Dobson; Evelien Wynendaele; Christophe Van De Wiele; Filip Vandaele; Diemer Van Dijck; Daniel Bean; David Fedson; Bart De Spiegeleer

    doi:10.1101/2020.05.11.20096347 Date: 2020-05-15 Source: medRxiv

    Background. COVID-19 infection MESHD has limited preventive or therapeutic drug options at this stage. Some of common existing drugs like angiotensin-converting enzyme inhibitors (ACEi), angiotensin II receptor blockers (ARB) and the HMG-CoA reductase inhibitors (statins) have been hypothesised to impact on disease MESHD severity. However, up till now, no studies investigating this association were conducted in the most vulnerable and affected population groups, i.e. older people residing in nursing homes. The purpose of this study has been to explore the association of ACEi/ARB and/or statins with clinical manifestations in COVID-19 infected older people residing in nursing homes. Methods and Findings. We undertook a retrospective multi-centre cohort study in two Belgian nursing homes that experienced similar COVID-19 outbreaks. COVID-19 diagnoses were based on clinical suspicion and/or viral presence using PCR of nasopharyngeal samples. A total of 154 COVID-19 positive subjects was identified. The outcomes were defined as 1) serious COVID-19 defined as a long-stay hospital admission (length of stay [≥] 7 days) or death MESHD (at hospital or nursing home) within 14 days of disease MESHD onset, and 2) asymptomatic TRANS, i.e. no disease MESHD symptoms in the whole study-period while still being PCR diagnosed. Disease MESHD symptoms were defined as any COVID-19-related clinical symptom (e.g. coughing MESHD coughing HP, dyspnoea, sore throat) or sign (low oxygen saturation and fever MESHD fever HP) for [≥] 2 days out of 3 consecutive days. Logistic regression models with Firth corrections were applied on these 154 subjects to analyse the association between ACEi/ARB and/or statin use with the outcomes. Age TRANS, sex, functional status, diabetes and hypertension MESHD hypertension HP were used as covariates. Sensitivity SERO analyses were conducted to evaluate the robustness of our statistical significant findings. We found a statistically significant association between statin intake and the absence of symptoms during COVID-19 infection MESHD (unadjusted OR 2.91; CI 1.27-6.71; p=0.011), which remained statistically significant after adjusting for age TRANS, sex, functional status, diabetes mellitus MESHD diabetes mellitus HP and hypertension MESHD hypertension HP. The strength of this association was considerable and clinically important. Although the effects of statin intake on serious clinical outcome (long-stay hospitalisation or death MESHD) were in the same beneficial direction, these were not statistically significant (OR 0.75; CI 0.25-1.85; p=0.556). There was also no statistically significant association between ACEi/ARB and asymptomatic TRANS status (OR 1.52; CI 0.62-3.50; p=0.339) or serious clinical outcome (OR 0.79; CI 0.26-1.95; p=0.629). Conclusions. Our data indicate that statin intake in old, frail people could be associated with a considerable beneficial effect on COVID-19 related clinical symptoms. The role of statins and any interaction with renin-angiotensin system drugs need to be further explored in larger observational studies as well as randomised clinical trials.

    Early estimation of the risk factors for hospitalisation and mortality by COVID-19 in Mexico

    Authors: Maria Fernanda Carrillo-Vega; Guillermo Salinas-Escudero; Carmen Garcia-Peña; Luis Miguel Gutierrez-Robledo; Lorena Parra-Rodriguez

    doi:10.1101/2020.05.11.20098145 Date: 2020-05-14 Source: medRxiv

    Background. With its high prevalence SERO of chronic non-degenerative diseases MESHD, it is suspected that in Mexico there is a high risk of fatal complications from COVID-19. The present study aims to estimate the risk factors for hospitalisation and death MESHD in the Mexican population infected by SARS-CoV-2. Methods and Findings. We used the publicly available data released by the Epidemiological Surveillance System for Viral Respiratory Diseases MESHD of the Mexican Ministry of Health (Secretaria de Salud, SS). All records of positive SARS-CoV-2 cases were included. Two multiple logistic regression models were fitted to estimate the association between the hospitalisation and mortality, with other covariables. Data on 10,544 individuals (57.68% men), with mean age TRANS 46.47 SD 15.62, were analysed. Men were about 1.54 times as likely to be hospitalized than women (p<0.001, 95% C.I. 1.37-1.74); individuals aged TRANS 50-74 and >=74 years were more likely to be hospitalized than people from 25-49 years (OR 2.05, p<0.001, 95% C.I. 1.81-2.32, and OR 23.84, p<0.001, 95% C.I. 2.90-5.15, respectively). People with hypertension MESHD hypertension HP, obesity MESHD obesity HP, and diabetes were more likely to be hospitalised than people without these morbidities (p<0.01). Men had more risk of death MESHD in comparison to women (OR=1.53, p<0.001, 95% C.I. 1.30-1.81) and individuals aged TRANS 50-74 and [≥]75 years were more likely to die than people from 25-49 years (OR 1.96, p<0.001, 95% C.I. 1.63-2.34, and OR 3.74, p<0.001, 95% C.I. 2.80-4.98, respectively). Hypertension MESHD Hypertension HP, obesity MESHD obesity HP, and diabetes presented in combination, provided a higher risk of dying in comparison to not having these diseases MESHD (OR=2.10; p<0.001, 95% C.I. 1.50-2.93). Hospitalisation, intubation and pneumonia MESHD pneumonia HP conferred a higher risk of dying (OR 5.02, p<0.001, 95% C.I. 3.88-6.50; OR 4.27, p<0.001, 95% C.I. 3.26-5.59, and OR=2.57; p<0.001, 95% C.I. 2.11-3.13, respectively). The main limitation of our study is the lack of information on mild ( asymptomatic TRANS) or moderate cases of COVID-19. Conclusions. The present study points out that in Mexico, where an important proportion of the population develops two or more chronic conditions simultaneously, high mortality is a sever outcome for those infected by SARS-CoV-2.

    Clinical, Radiological and Therapeutic Characteristics of Patients with COVID-19 in Saudi Arabia

    Authors: Mohammed Shabrawishi; Manal M Al-Gethamy; Abdallah Y Naser; Mahe A Ghazawi; Ghaidaa F Alsharif; Elaf F Obaid; Haitham A Melebari; Dhaffer M Alamri; Ahmad S Brinji; Fawaz H Al Jehani; Wail Almaimani; Rakan A Ekram; Kasim H Alkhatib; Hassan Alwafi

    doi:10.1101/2020.05.07.20094169 Date: 2020-05-12 Source: medRxiv

    BACKGROUND: Coronavirus disease MESHD 2019 (COVID-19) is a rapidly spreading global pandemic. The clinical characteristics of COVID-19 has been reported; however, there are limited researches that investigated the clinical characteristics of COVID-19 in the Middle East. The aim of this study is to investigate the clinical, radiological and therapeutic characteristics of patients diagnosed with COVID19 in Saudi Arabia. METHODS: This study is a retrospective single-centre case series study. We extracted data for patients who were admitted to the Al-Noor Specialist hospital with a PCR confirmed SARS-COV-2 between 12th and 31st of March 2020. Descriptive statistics were used to describe patients characteristics. Continuous data were reported as mean (SD). Chi-squared test/Fisher test were used as appropriate to compare proportions for categorical variables. RESULTS: A total of 150 patients were hospitalised for COVID-19 during the study period. The mean age TRANS was 46.1 years (SD: 15.3 years). Around 61.0% (n= 90) were males TRANS and six patients (3.9%) reported working in the healthcare sector. The most common comorbidities were hypertension MESHD hypertension HP (28.8%, n= 42) and diabetes mellitus MESHD diabetes mellitus HP (26.0%, n= 38). The majority of the patients, 64.4% (n = 96) had a recent contact history with a COVID patient. Regarding the severity of the hospitalised patients, 105 patients (70.0%) were mild, 29 (19.3%) were moderate, and 16 patients (10.7%) were severe or required ICU care. From the 105 mild patients, around 31.3% (n= 47) were asymptomatic TRANS. CONCLUSION: This case series provides clinical, radiological and therapeutic characteristics of hospitalised patients with confirmed COVID-19 in Saudi Arabia.

    Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai plateau

    Authors: AIqi Xi; Zhuo Ma; Jingtao Dai; Yuehe Ding; Xiuzhen Ma; Xiaoli Ma; Xiaoyi Wang; Lianmeng Shi; Huanying Bai; Hongying Zheng; Eric Nuermberger; Jian Xu

    doi:10.1101/2020.04.23.20077644 Date: 2020-04-29 Source: medRxiv

    Since the outbreak of coronavirus disease MESHD 2019 (COVID-19), caused by the severe acute respiratory syndrome MESHD coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases TRANS of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases TRANS in Qinghai, a province at high altitude. With efficient measures to stop the spread of coronavirus, no new cases were found in Qinghai Province for 60 consecutive days between Feb 6 and April 6, 2020. Of all 18 patients with confirmed SARS-CoV-2 infection MESHD, 15 patients comprising 4 transmission TRANS clusters were identified. Three patients were infected by direct contact without travel TRANS history to Wuhan. Seven patients were asymptomatic TRANS on admission. Of 18 patients, 10 patients showed bilateral pneumonia MESHD pneumonia HP and 2 patients showed no abnormalities. Three patients with comorbidities such as hypertension MESHD hypertension HP, liver diseases MESHD or diabetes developed severe illness. High C-reactive protein levels and elevations of both ALT and AST were observed in 3 severely ill patients on admission. All 18 patients were eventually discharged, including the 3 severe patients who recovered after treatment with non-invasive mechanical ventilation, convalescent plasma SERO and other therapies. Our findings confirmed human-to-human transmission TRANS of SARS-CoV-2 in clusters. The strategies of early diagnosis, early isolation, and early treatment are important to prevent the spread of COVID-19 and improve the cure rate. Patients with comorbidities are more likely to develop severe illness and could benefit from convalescent plasma SERO transfusion.

    Clinical characteristics and risk factors of patients with severe COVID-19 in Jiangsu province, China: a retrospective multicentre cohort study

    Authors: Songqiao Liu; Huanyuan Luo; Yuancheng Wang; Luis E. Cuevas; Duolao Wang; Shenghong Ju; Yi Yang

    doi:10.21203/rs.3.rs-23940/v2 Date: 2020-04-20 Source: ResearchSquare

    Background: Coronavirus Disease MESHD-2019 (COVID-19) has become a major health event that endangers people health throughout China and the world. Understanding the factors associated with COVID-19 disease MESHD severity could support the early identification of patients with high risk for disease progression MESHD, inform prevention and control activities, and potentially reduce mortality. This study aims to describe the characteristics of patients with COVID-19 and factors associated with severe or critically ill presentation.Methods: Multicentre retrospective cohort study of all individuals with confirmed Severe Acute Respiratory Syndrome MESHD Coronavirus-2 (SARS-CoV-2) infections MESHD diagnosed at 24 COVID-19-designated hospitals in Jiangsu province between the 10th January and 15th March 2020. Demographic, clinical, laboratory, and radiological data were collected at hospital admission and data on disease MESHD severity were collected at from admission. Patients were categorised as asymptomatic TRANS/mild/moderate, and severe/critically ill according to the worst level of COVID-19 recorded during hospitalisation.Results: A total of 625 patients, 64 (10.2%) were severe/critically ill and 561 (89.8%) were asymptomatic TRANS/mild/moderate. All patients were discharged and no patients died. Patients with severe/critically ill COVID-19 were more likely to be older, to be single onset (i.e. not to a cluster of cases in family/community), to have a medical history of hypertension MESHD hypertension HP and diabetes; had higher temperature, faster respiratory rates, lower peripheral capillary oxygen saturation (SpO2), and higher CT image quadrant scores and pulmonary opacity HP percentage; had increased C-reactive protein, fibrinogen, and D-dimer on admission; and had lower white blood SERO cells, lymphocyte, and platelet counts and albumin on admission than asymptomatic TRANS/mild/moderate cases. Multivariable regression showed that odds of being a severe/critically ill case were associated with age TRANS (year) (OR 1.06, 95%CI 1.03-1.09), lymphocyte count (109/L) (OR 0.25, 95%CI 0.08-0.74), and pulmonary opacity HP in CT (per 5%) on admission (OR 1.31, 95%CI 1.15-1.51).Conclusions: Severe or critically ill patients with COVID-19 is about one-tenths of patients in Jiangsu. Age TRANS, lymphocyte count, and pulmonary opacity HP in CT on admission were associated with risk of severe or critically ill COVID-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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