Corpus overview


MeSH Disease

Human Phenotype

Hypertension (190)

Fever (57)

Cough (48)

Pneumonia (36)

Obesity (27)


    displaying 161 - 170 records in total 190
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    The clinical characteristics and mortal causes analysis of COVID-19 death MESHD patients

    Authors: Ao-Xiang Guo; Jia-Jia Cui; Qian-Ying OuYang; Li He; Cheng-Xian Guo; Ji-Ye Yin

    doi:10.1101/2020.04.12.20062380 Date: 2020-04-15 Source: medRxiv

    Abstract Purpose: Currently, COVID-19 is causing a large number of deaths globally. However, few researches focused on the clinical features of death MESHD patients. This study conducted a retrospective analysis of clinical characteristics and mortal causes in Chinese COVID-19 death MESHD patients. Patients and methods: The clinical characteristics of death MESHD patients were collected from publicized by local health authorities in China. Expressions of virus targets in human organs were obtained from GTEx database. Results: 159 patients from 24 provinces in China were recruited in our study, including 26 young patients under 60 and 133 aged TRANS 60 or older. The median age TRANS was 71 years, which indicated that most death MESHD patients were elderly TRANS. More male TRANS patients died of COVID-19 than females TRANS (1.65 fold). Hypertension HP Hypertension MESHD was the most common coexisting disorder and respiratory failure HP respiratory failure MESHD was the most common direct cause of death MESHD. Fever HP Fever MESHD (71.19%) and cough HP (55.08%) were the predominant presenting symptoms. There was one asymptomatic TRANS patient. In addition, by comparing young and old patients, heart disease MESHD was identified as an important risk factor for death MESHD in the aged TRANS patients. ACE2 and TMPRSS2 were the targets of SARS-CoV-2, we analyzed their expression in different organs. TMPRSS2 and ACE2 had a high expression in the organs which had corresponding clinical features in death MESHD patients. Conclusion: Male TRANS, age TRANS and heart disease MESHD were the main risk factors of death. Beside, asymptomatic TRANS patients with serious coexisting disorders may also die of SARS-CoV-2. Thus, more attention should be paid to the old patients with heart disease MESHD and asymptomatic TRANS patients in the treatment . Keywords: COVID-19, SARS-Cov-2, death, coexisting disorder, cause of death MESHD

    Risk factors for mortality of adult TRANS inpatients with Coronavirus disease MESHD 2019 (COVID-19): a systematic review and meta-analysis of retrospective studies

    Authors: Mohammad Parohan; Sajad Yaghoubi; Asal Seraji; Mohammad Hassan Javanbakht; Payam Sarraf; Mahmoud Djalali

    doi:10.1101/2020.04.09.20056291 Date: 2020-04-11 Source: medRxiv

    Purpose: Coronavirus disease 2019 (COVID-19) is an emerging disease that was first reported in Wuhan city, the capital of Hubei province in China, and has subsequently spread worldwide. Risk factors for mortality have not been well summarized. Current meta-analysis of retrospective cohort studies was done to summarize available findings on the association between age TRANS, gender TRANS, comorbidities and risk of death from COVID-19 infection MESHD. Methods: Online databases including Web of Science, PubMed, Scopus, Cochrane Library and Google scholar were searched to detect relevant publications up to 1 May 2020, using relevant keywords. To pool data, random-effects model was used. Furthermore, sensitivity SERO analysis and publication bias test were also done. Results: In total, 14 studies with 29,909 COVID-19 infected MESHD patients and 1,445 cases of death MESHD were included in the current meta-analysis. Significant associations were found between older age TRANS ([≥]65 vs <65 years old) (pooled ORs=4.59, 95% CIs=2.61-8.04, p<0.001), gender TRANS ( male TRANS vs female TRANS) (pooled ORs=1.50, 95% CIs=1.06-2.12, p=0.021) and risk of death from COVID-19 infection MESHD. In addition, hypertension HP hypertension MESHD (pooled ORs=2.70, 95% CIs=1.40-5.24, p=0.003), cardiovascular diseases MESHD ( CVDs MESHD) (pooled ORs=3.72, 95% CIs=1.77-7.83, p=0.001), diabetes MESHD (pooled ORs=2.41, 95% CIs=1.05-5.51, p=0.037), chronic obstructive pulmonary disease HP chronic obstructive pulmonary disease MESHD ( COPD MESHD) (pooled ORs=3.53, 95% CIs=1.79-6.96, p<0.001) and cancer MESHD (pooled ORs=3.04, 95% CIs=1.80-5.14, p<0.001), were associated with higher risk of mortality. Conclusion: Older age TRANS ([≥]65 years old), male TRANS gender TRANS, hypertension HP hypertension MESHD, CVDs MESHD, diabetes MESHD, COPD MESHD and malignancies MESHD were associated with greater risk of death from COVID-19 infection MESHD. These findings could help clinicians to identify patients with poor prognosis at an early stage.

    Treatment with ACE-inhibitors is associated with less severe disease with SARS-Covid-19 infection MESHD in a multi-site UK acute Hospital Trust

    Authors: Daniel Bean; Zeljko Kraljevic; Thomas Searle; Rebecca Bendayan; Andrew Pickles; Amos Folarin; Lukasz Roguski; Kawsar Noor; Anthony Shek; Rosita Zakeri; Ajay Shah; James Teo; Richard JB Dobson

    doi:10.1101/2020.04.07.20056788 Date: 2020-04-11 Source: medRxiv

    Aims: The SARS-Cov2 virus binds to the ACE2 receptor for cell entry. It has been suggested that ACE- inhibitors (ACEi) and Angiotensin-2 Blockers (ARB), which are commonly used in patients with hypertension HP hypertension MESHD or diabetes MESHD and may raise ACE2 levels, could increase the risk of severe COVID19 infection MESHD. Methods and Results: We evaluated this hypothesis in a consecutive cohort of 1200 acute inpatients with COVID19 at two hospitals with a multi-ethnic catchment population in London (UK). The mean age TRANS was 68+-17 years (57% male TRANS) and 74% of patients had at least 1 comorbidity. 415 patients (34.6%) reached the primary endpoint of death MESHD or transfer to a critical care unit for organ support within 21-days of symptom onset TRANS. 399 patients (33.3 %) were taking ACEi or ARB. Patients on ACEi/ARB were significantly older and had more comorbidities. The odds ratio (OR) for the primary endpoint in patients on ACEi and ARB, after adjustment for age TRANS, sex and co-morbidities, was 0.63 (CI 0.47-0.84, p<0.01). Conclusions: There was no evidence for increased severity of COVID19 disease in hospitalised patients on chronic treatment with ACEi or ARB. A trend towards a beneficial effect of ACEi/ARB requires further evaluation in larger meta-analyses and randomised clinical trials.

    Acute kidney injury HP kidney injury MESHD in patients hospitalized with COVID-19 in Wuhan, China: A single-center retrospective observational study

    Authors: Guanhua Xiao; Hongbin Hu; Feng Wu; Tong Sha; Qiaobing Huang; Haijun Li; Jiafa Han; Wenhong Song; Zhongqing Chen; Zhenhua Zeng

    doi:10.1101/2020.04.06.20055194 Date: 2020-04-08 Source: medRxiv

    Background: The kidney may be affected in coronavirus-2019 disease (COVID-19). This study assessed the predictors and outcomes of acute kidney injury HP acute kidney injury MESHD ( AKI MESHD) among individuals with COVID-19. Methods: This observational study, included data on all patients with clinically confirmed COVID-19 admitted to Hankou Hospital, Wuhan, China from January 5 to March 8, 2020. Data were extracted from clinical and laboratory records. Follow-up was censored on March 8, 2020. This is a single-center, retrospective, observational study. Patients clinically confirmed COVID-19 and admitted to Hankou Hospital, Wuhan, China from January 5 to March 8, 2020 were enrolled. We evaluated the association between changes in the incidence of AKI MESHD and COVID-19 disease and clinical outcomes by using logistic regression models. Results: A total of 287 patients, 55 with AKI MESHD and 232 without AKI MESHD, were included in the analysis. Compared to patients without AKI MESHD, AKI MESHD patients were older, predominantly male TRANS, and were more likely to present with hypoxia MESHD and have pre-existing hypertension HP hypertension MESHD and cerebrovascular disease MESHD. Moreover, AKI MESHD patients had higher levels of white blood SERO cells, D-dimer, aspartate aminotransferase, total bilirubin, creatine kinase, lactate dehydrogenase, procalcitonin, C-reactive protein, a higher prevalence SERO of hyperkalemia HP hyperkalemia MESHD, lower lymphocyte counts, and higher chest computed tomographic scores. The incidence of stage 1 AKI MESHD was 14.3%, and the incidence of stage 2 or 3 AKI MESHD was 4.9%. Patients with AKI MESHD had substantially higher mortality. Conclusions: AKI MESHD is an important complication of COVID-19. Older age TRANS, male TRANS, multiple pre-existing comorbidities, lymphopenia HP lymphopenia MESHD, increased infection indicators, elevated D-dimer, and impaired heart and liver functions MESHD were the risk factors of AKI MESHD. AKI MESHD patients who progressed to stages 2 or 3 AKI MESHD had a higher mortality rate. Prevention of AKI MESHD and monitoring of kidney function is very important for COVID 19 patients.

    The relationship of COVID-19 severity with cardiovascular disease MESHD and its traditional risk factors: A systematic review and meta-analysis

    Authors: Kunihiro Matsushita; Ning Ding; Minghao Kou; Xiao Hu; Mengkun Chen; Yumin Gao; Yasuyuki Honda; David Dowdy; Yejin Mok; Junichi Ishigami; Lawrence J Appel

    doi:10.1101/2020.04.05.20054155 Date: 2020-04-07 Source: medRxiv

    Background: Whether cardiovascular disease MESHD ( CVD MESHD) and its traditional risk factors predict severe coronavirus disease MESHD 2019 (COVID-19) is uncertain, in part, because of potential confounding by age TRANS and sex. Methods: We performed a systematic review of studies that explored pre-existing CVD MESHD and its traditional risk factors as risk factors of severe COVID-19 (defined as death MESHD, acute respiratory distress syndrome MESHD respiratory distress HP syndrome, mechanical ventilation, or intensive care unit admission). We searched PubMed and Embase for papers in English with original data ([≥]10 cases of severe COVID-19). Using random-effects models, we pooled relative risk (RR) estimates and conducted meta-regression analyses. Results: Of the 661 publications identified in our search, 25 papers met our inclusion criteria, with 76,638 COVID-19 patients including 11,766 severe cases. Older age TRANS was consistently associated with severe COVID-19 in all eight eligible studies, with RR >~5 in >60-65 vs. <50 years. Three studies showed no change in the RR of age TRANS after adjusting for covariate(s). In univariate analyses, factors robustly associated with severe COVID-19 were male TRANS sex (10 studies; pooled RR=1.73, [95%CI 1.50-2.01]), hypertension HP hypertension MESHD (8 studies; 2.87 [2.09-3.93]), diabetes MESHD (9 studies; 3.20 [2.26-4.53]), and CVD MESHD (10 studies; 4.97 [3.76-6.58]). RR for male TRANS sex was likely to be independent of age TRANS. For the other three factors, meta-regression analyses suggested confounding by age TRANS. Only four studies reported multivariable analysis, but most of them showed adjusted RR ~2 for hypertension HP hypertension MESHD, diabetes MESHD, and CVD MESHD. No study explored renin-angiotensin system inhibitors as a risk factor for severe COVID-19. Conclusions: Despite the potential for confounding, these results suggest that hypertension HP hypertension MESHD, diabetes MESHD, and CVD MESHD are independently associated with severe COVID-19 and, together with age TRANS and male TRANS sex, can be used to inform objective decisions on COVID-19 testing, clinical management, and workforce planning.

    A meta-analysis of 2019 novel corona virus patient clinical characteristics and comorbidities

    Authors: Subodh Sharma Paudel

    doi:10.21203/ Date: 2020-04-07 Source: ResearchSquare

    IntroductionBeing a new variant of coronavirus, detailed information regarding the virulence, its clinical characters, high risk individuals are yet to be defined. This study was done with the objective of finding out clinical features of corona infection MESHD and also studies what are the comorbidities that are associated with it.MethodsThis is a single arm meta-analysis in which relevant data were derived from searches in PubMed. It includes study papers which were written in English language and their completely published article is found. Seven articles published from 24th Jan to 16th March, 2020 are included in this study. ResultsThe total number of patients was 1786 with 1044 males TRANS and 742 females TRANS with male TRANS to female TRANS ratio of 1.4:1. The median age TRANS of patients was 41 years). Fever HP Fever MESHD was present in 88.8% cases. Dry Cough HP in 68% followed by fatigue HP fatigue MESHD in 33%. Hypertension HP Hypertension MESHD (15.8%) is the most common comorbidity followed by cardio and cerebrovascular condition (11.7%). ConclusionPatients often presented with symptoms of fever HP fever MESHD, dry cough MESHD cough HP, lethargy HP lethargy MESHD and fatigue HP fatigue MESHD, muscle pain MESHD pain HP, productive cough HP. Similarly, patients with previous history of HTN, DM MESHD, COPD MESHD, cardio and cerebrovascular condition, immune-deficient states are at high risk of developing into the severe COVID-19 infection MESHD.

    Comparison of clinical characteristics and risk factors in hospitalized patients with SARS-CoV-2, MERS-CoV, and SARS-CoV infection MESHD

    Authors: Zhengtu Li; Xidong Wang; Guansheng Su; Shaoqiang Li; Yuwei Ye; Qiuxue Deng; Jinchuang Li; Xiaoyu Xiong; Xinguang Wei; Zeqiang Lin; Zichen Jie; Feng Ye

    doi:10.21203/ Date: 2020-04-05 Source: ResearchSquare

    Herein, we compared the risk factors, clinical presentation of patients hospitalized with  SARS-CoV-2, SARS-CoV MESHD, or MERS-CoV infection MESHD. The proportion of male TRANS patients with COVID-19 was higher than who with SARS but lower than who with MERS (p<0.001). More patients with COVID-19 had coexisting chronic medical conditions than those with SARS (p<0.001) but fewer than those with MERS (p<0.001), and the prevalence SERO of hypertension HP hypertension MESHD (17%) and smoking history (14%) was higher than in patients with SARS (p<0.001). Furthermore,the symptom of fever HP fever MESHD (53%), hemoptysis HP (1%), diarrhea HP diarrhea MESHD (4%) and vomiting HP vomiting MESHD (3%) of COVID-19 were significantly lower than that in patients with SARS or MERS. The level of ALT and AST in COVID-19 was significantly lower (p<0.001), however, thrombocytopenia HP thrombocytopenia MESHD, high LDH were common. Summary, male TRANS, smoking history and hypertension HP hypertension MESHD were the most common risk factors for hospitalization with COVID-19; and the clinical feature was less severe in COVID-19.

    Clinical characteristics of 208 patients with COVID-19 in a surrounding city of Wuhan, China

    Authors: Xin Chen; Peng Chen; Dodji Kossi Djakpo; Yan Lin; Rong Zhang; Zhiquan Wang

    doi:10.21203/ Date: 2020-04-01 Source: ResearchSquare

    Background: Since December 2019, a severe novel coronavirus ( SARS-CoV-2) infection (Coronavirus Disease MESHD 2019,COVID-19) has occurred in Wuhan, China, and has rapidly spread to the country and around the world. This study intends to investigate the epidemiological and clinical characteristics of patients with COVID-19 in a surrounding city of Wuhan.Methods: A retrospective study was conducted on 208 cases of COVID -19 patients from February 11, 2020 to February 29, 2020 in Xiaogan dongnan Hospital, collected basic information, history of exposure, medical history, clinical symptoms, laboratory indicators and pulmonary imaging Data, and analyzed the epidemiological and clinical characteristics of all patients. According to the clinical classification criteria, 208 patients were divided into light group and ordinary group, and the epidemiological and clinical characteristics of the two groups were compared.Results: Among 208 patients in this study, with a median age TRANS of 50.5 years (IQR,36-64.7,range,10-91 years), among which 107 (51.4%) were males TRANS and 101 (48.6%) were females TRANS. 51 (24.5%) had a clear exposure to COVID-19 infection within 2 weeks before admission, and 40 (19.2%) had a history of residence or exposure in Wuhan within 2 weeks before admission. Among all the patients, there were 16 (7.7%) with pulmonary diseases MESHD, 41 (19.7%) with hypertension HP hypertension MESHD, 11 (5.3%) with coronary heart disease MESHD, 13 (6.3%) with diabetes MESHD, 12(5.8%) with a history of alcohol consumption, and 12(5.8%) with a history of smoking. Among all clinical symptoms, 146 cases (70.2%) of fever HP fever MESHD, the highest temperature range was 37.3℃-41℃ before admission, 115 (55.3%) cases of cough HP, and 57 (27.4%) cases of chest tightness HP chest tightness MESHD, 47 (22.6%) cases of fatigue HP fatigue MESHD, 28 (13.5%) cases of inappetence, 9 (4.3%) cases of diarrhea HP diarrhea MESHD, 7 (3.4%) cases of nasal congestion or runny nose , and 5 ( 2.4%) cases of pharyngalgia. Analysis of the laboratory results of 208 patients showed that 42 (20.2%) cases had decreased white blood SERO cell count, and 61 (29.3%) cases had decreased lymphocyte count. There were 154 (74%) cases with elevated CRP, 50 (24%) cases with elevated fasting blood SERO glucose, and 23 (11.1%) cases with elevated LDH (>245U/L). The comparison of clinical characteristics between the light group and the common group showed that the median age TRANS of the light group was 44.8 years (IQR 30-58), the median age TRANS of the common group was 53.1 years (IQR 38.8-67) (P<0.01). The symptoms of fever HP fever MESHD [53(80.3%) vs 93(65.5%),P<0.05], fatigue HP fatigue MESHD [53(80.3%) vs 93(65.5%),P<0.05] and inappetence [4(6.1%) vs 24(16.9%),P<0.05] in the light group were less than those in the common group. The white blood SERO cell count (5.48 vs 6.37, P<0.05), lymphocyte count (1.40 vs 1.61, P<0.05) and HDL-C (1.5 vs 1.3, P<0.05) of the common group were lower than that of the light group, while CRP (26.5 vs 22.1, P<0.01), AST (22.9 vs 18.5, P<0.05), fasting blood SERO glucose (5.8 vs 5.6, P<0.05), LDH (196.8 vs 157.9, P<0.001) of the common group were higher than that of the light group.Conclusion: COVID-19 infection is mainly in middle- aged TRANS and elderly TRANS patients, patients with other diseases MESHD are more susceptible to infection. The main symptoms of COVID-19 infection MESHD were fever HP fever MESHD, cough HP cough MESHD, chest tightness HP chest tightness MESHD, fatigue HP fatigue MESHD, and inappetence. Decreased lymphocyte count, increased CRP concentration, increased LDH concentration and decreased HDL-C concentration were the laboratory features of COVID-19 infection MESHD, and were important indicators to assess the severity of COVID-19 disease.

    Risk factors for severe corona virus disease MESHD 2019 (COVID-19) patients : a systematic review and meta analysis

    Authors: Lizhen Xu; mao yaqian; Gang Chen

    doi:10.1101/2020.03.30.20047415 Date: 2020-04-01 Source: medRxiv

    Importance: With the increasing number of infections MESHD for COVID-19, the global health resources are deficient. At present, we don't have specific medicines or vaccines against novel coronavirus pneumonia MESHD pneumonia HP (NCP) and our assessment of risk factors for patients with severe pneumonia HP pneumonia MESHD was limited. In order to maximize the use of limited medical resources, we should distinguish between mild and severe patients as early as possible. Objective: To systematically review the evidence of risk factors for severe corona virus disease MESHD 2019 (COVID-19) patients. Evidence Review: We conducted a comprehensive search for primary literature in both Chinese and English electronic bibliographic data bases including China National Knowledge Infrastructure (CNKI), Wanfang, Weipu, Chinese Biomedicine Literature Database (CBM-SinoMed), MEDLINE (via PubMed), EMBASE, Cochrane Central Register, and Web of science. The American agency for health research and quality (AHRQ) tool were used for assessing risk of bias. Mata-analysis was undertaken using STATA version 15.0. Results: 20 articles (N=4062 participants) were eligible for this systematic review and meta-analysis. First in this review and meta-analysis, we found that elderly TRANS male TRANS patients with a high body mass index, high breathing rate and a combination of underlying diseases (such as hypertension HP hypertension MESHD, diabetes MESHD, cardiovascular disease MESHD disease, and chronic obstructive pulmonary HP chronic obstructive pulmonary disease MESHD) were more likely to develop into critically ill MESHD patients. second, compared with ordinary patients, severe patients had more significant symptom such as fever HP fever MESHD and dyspnea HP dyspnea MESHD. Besides, the laboratory test results of severe patients had more abnormal than non-severe patients, such as the elevated levels of white-cell counts, liver enzymes, lactate dehydrogenase, creatine kinase, c-reactive protein and procalcitonin, etc, while the decreased levels of lymphocytes and albumin, etc. Interpretation: This is the first systematic review investigating the risk factors for severe corona virus disease MESHD 2019 (COVID-19) patients. The findings are presented and discussed by different clinical characteristics. Therefore, our review may provide guidance for clinical decision-making and optimizes resource allocation.

    Early Epidemiological analysis of CoVID-19:  First report from South of Iran

    Authors: Ali Akbari; Amir Emami; Fatemeh Javanmardi; Neda Pirbonyeh; Nima Fadakar

    doi:10.21203/ Date: 2020-03-28 Source: ResearchSquare

    Background: Despite the whole world’s effort for controlling, an ongoing global outbreak of lower respiratory tract disease MESHD, caused by new corona virus; led to a major public health issue. Current study aims to evaluate the characteristics of infected case in Fars, IranMethods: According to the referral of suspicious patients during one month, 2538 samples were evaluated and extracted for Viral RNA nucleic acids by using the Invitrogen ChargeSwitch® Total RNA Cell Kit (Invitrogen Co.). Data were recorded based on the standardized data collection forms shared by WHO and the International Severe Acute Respiratory and Emerging Infection MESHD Consortium. Results: By 19 March 2020, 440 admitted patients had been identified with CoVID-19 confirmation. More than 50% of cases were men. Mean age TRANS were estimated 48.15 ±18.07. Of all the patients, 30 (6.81%) had a history of travel TRANS to Qom city, which was the first infected zone in Iran, also 92(20.90%) had close contact TRANS with contaminated or suspected individuals. The mortality rate was estimated 2. 95% (13 cases). Cardiovascular disease MESHD (25, 5.68%), diabetes MESHD (33, 7.5%), and hypertension HP hypertension MESHD (35, 7.95%) were the most common co-existing disorders. Patients with underlying disease are more in danger of death [OR: 11.64, (95%CI 3.14 – 43.18), p= 0.0002]. Conclusion: Human to human transmission TRANS of SARS-CoV-II MESHD causes Fars province in southwest of Iran become infected and 440 cases identified during one month. The SARS-Cov-2 is more likely to affect male TRANS sex and individuals with old age TRANS and underlying disorders. 

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MeSH Disease
Human Phenotype

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