Corpus overview


MeSH Disease

Human Phenotype

Cough (2)

Headache (2)

Skin rash (2)

Fever (1)

Fatigue (1)


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    Differentiating coronavirus disease MESHD 2019 (COVID-19) from influenza and dengue

    Authors: Tun-Linn Thein; Li Wei Ang; Barnaby Edward Young; Mark IC Chen; Yee-Sin Leo; David Chien Lye

    doi:10.21203/ Date: 2020-06-18 Source: ResearchSquare

    Background: The novel coronavirus disease MESHD 2019 (COVID-19) presents with non-specific clinical features. This may result in misdiagnosis or delayed diagnosis, and lead to further transmission TRANS in the community. We aimed to derive early predictors to differentiate COVID-19 from influenza and dengue.Methods: The study comprised 126 patients with COVID-19, 171 with influenza and 180 with dengue, who presented within 5 days of symptom onset TRANS. All cases were confirmed TRANS by reverse transcriptase polymerase chain reaction tests. We used logistic regression models to identify clinical characteristics and laboratory markers in classifying COVID-19 versus influenza, and COVID-19 versus dengue. The performance SERO of the models were evaluated using receiver operating characteristic curves (ROC).Results: Shortness of breath MESHD was the strongest predictor in the models for differentiating between COVID-19 and influenza, followed by diarrhoea MESHD. Higher lymphocyte count was predictive of COVID-19 versus influenza and versus dengue. In the model for differentiating between COVID-19 and dengue, patients with cough HP cough MESHD and higher platelet count were at increased odds of COVID-19, while headache HP headache MESHD, joint pain MESHD pain HP, skin rash HP skin rash MESHD and vomiting/nausea HP vomiting/nausea MESHD nausea MESHD were indicative of dengue. The area under the ROC was 0.92 for flu model and 0.99 for dengue model.Conclusion: Models based on clinical features and simple laboratory markers for differentiating COVID-19 from influenza and dengue, which possess good predictive performance SERO, can serve as a useful tool for primary care physicians to determine if further investigations or referrals would be required.

    COVID-19 may present with an itchy erythematous papular rash MESHD: a case report

    Authors: Alice Serafini; Peter K. Kurotschka; Mariabeatrice Bertolani; Silvia Riccomi

    doi:10.21203/ Date: 2020-05-06 Source: ResearchSquare

    Background: the most commonly reported clinical manifestations of Coronavirus Disease MESHD (COVID- 19) are: fever HP, fatigue HP fatigue MESHD, dry cough MESHD cough HP, anorexia HP anorexia MESHD, myalgias HP myalgias MESHD, dyspnoea MESHD and sputum production. Other, rarer, manifestations include headache HP headache MESHD, sore throat, rhinorrhoea, nausea HP nausea MESHD, diarrhoea and olfactory or taste disorders MESHD. Two recent small-scale studies suggest the possibility of a skin rash HP skin rash MESHD being a clinical presentation of the disease. The purpose of our case report is to bring attention to an atypical presentation of the disease ( skin rash HP skin rash MESHD) and reflect on the importance of the correct identification of COVID-19 suspicious symptoms as part of the crucial activity of case-finding in primary care.Case presentation: the patient is an Italian 32 years old female TRANS nurse who has had several close contacts TRANS to COVID-19 cases during her working shifts. On the 13 th March 2020 she developed an itchy erythematous papular rash MESHD sparing only her sparing only her face, scalp and abdomen. One week later she developed fever HP fever MESHD and diarrhoea MESHD. During the first week of remote assessment carried out by her General Practitioner (GP), she gradually developed a dry cough MESHD cough HP, intermittent fever HP fever MESHD and diarrhoea MESHD. At the time of article submission (31 days after the symptoms onset TRANS), she has not completely recovered and is still suffering of a dry cough MESHD cough HP, headache HP headache MESHD, fatigue HP fatigue MESHD and, occasionally, diarrhoea MESHD.Conclusions: this study suggest that skin manifestations could be an early presentation of COVID-19 and, during outbreaks, they should be taken into proper account by primary care providers as possibly caused by Sars-Cov-2. Early identification of COVID-19 patients is a crucial part of the strategy of case detection and case isolation, which has shown to be crucial in the reduction of incidence and COVID-19-related mortality. Further research is needed to establish frequency, symptoms, signs, pathogenesis and role in case detection of skin manifestations in COVID-19 patients.

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MeSH Disease
Human Phenotype

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