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Human Phenotype

Transmission

Seroprevalence
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    Tuberculous Pericarditis MESHD Pericarditis HP with tamponade in COVID-19: A case report

    Authors: SHIUN WOEI WONG; Jessica Ng Ke Xuan; Chia Yew Woon

    doi:10.21203/rs.3.rs-45055/v1 Date: 2020-07-17 Source: ResearchSquare

    IntroductionTuberculous pericarditis MESHD pericarditis HP is a rare manifestation of tuberculosis infection MESHD. COVID-19 pandemic poses a challenge in detecting uncommon disease. Pericardial effusion HP with tamponade has been described with COVID-19 but the association with tuberculosis MESHD is not yet known. Case presentationA 47-year-old man was admitted with symptoms of COVID-19 infection MESHD. Rapid progression of cardiomegaly HP cardiomegaly MESHD on radiograph with clinical deterioration were suggestive of pericardial tamponade. Urgent pericardiocentesis revealed hemoserous fluid, elevated adenosine deaminase and positive TB PCR. He was started on steroid, anti-tuberculous therapy and Remdesivir with marked improvement of symptoms. Repeat echocardiogram and CT Thorax showed resolution of pericardial fluid and patient was discharged well. ConclusionsThis case highlights the difficulty in detecting a concomitant rare but important disease. The development of massive pericardial tamponade acutely is not pathognomonic for COVID-19, and a careful diagnostic process involving multi-modality imaging, occurred to arrive at a diagnosis of tuberculosis MESHD.

    Unusual Presentation of Kawasaki Disease MESHD with Multisystem Inflammation MESHD and Antibodies SERO Against Severe Acute Respiratory Syndrome MESHD Coronavirus 2: A Case Report

    Authors: Haena Kim; Jung Yeon Shim; Jae-Hoon Ko; Aram Yang; Jae Won Shim; Deok Soo Kim; Hye Lim Jung; Ji Hee Kwak; In Suk Sol

    doi:10.21203/rs.3.rs-41276/v1 Date: 2020-07-12 Source: ResearchSquare

    Background: Since mid-April 2020, cases of multisystem inflammatory syndrome MESHD in children TRANS (MIS-C) associated with coronavirus disease MESHD (COVID-19) that mimic Kawasaki disease MESHD ( KD MESHD) have been reported in Europe and North America. However, no cases have been in East Asia, where KD MESHD is more prevalent.Case presentation: A previously healthy 11-year-old boy was admitted with a 4-day history of fever HP fever MESHD and abdominal pain HP abdominal pain MESHD. He had no contact history to any patient with COVID-19. Blood SERO acute inflammatory markers were highly elevated. He was treated with antibiotics for suspected bacterial enteritis MESHD, but he suddenly developed hypotension HP hypotension MESHD. Inotropics and intravenous immunoglobulin were administered to manage septic shock MESHD shock HP. On hospitalization day 6, he developed signs and symptoms of KD MESHD (conjunctival injection, strawberry tongue HP, cracked lip MESHD, and coronary artery dilatation MESHD dilatation HP) in addition to pleural/pericardial effusion MESHD pericardial effusion HP and mesenteric lymphadenitis HP lymphadenitis MESHD. The results of microbiologic tests, including reverse-transcription polymerase chain reaction for severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2), were negative. Fluorescent immunoassay SERO and enzyme-linked immunosorbent assay SERO revealed abundant IgG antibodies SERO against SARS-CoV-2 in his serum SERO, but no IgM antibodies SERO. He was discharged successfully on day 13.Conclusion: MIS-C may occur in children TRANS with a previously asymptomatic TRANS COVID-19 infection MESHD. A high index of suspicion is required for this novel syndrome in unusual cases of KD MESHD or KD shock syndrome MESHD shock HP syndrome with multisystem inflammation MESHD, even when there is no clear history of contact or symptoms of COVID-19.

    CT Imaging Changes of Corona Virus Disease MESHD 2019 (COVID-19):A multi-center study in Southwest China

    Authors: Xiaoming Li; Wenbing Zeng; Xiang Li; Haonan Chen; Linping Shi; Xinghui Li; Hongnian Xiang; Yang Cao; Hui Chen; Chen Liu; Jian Wang

    doi:10.21203/rs.3.rs-16974/v2 Date: 2020-03-09 Source: ResearchSquare

    Background: Since the first case of a coronavirus disease MESHD 2019 (COVID-19) infection pneumonia MESHD pneumonia HP was detected in Wuhan, China, a series of confirmed cases TRANS of the COVID-19 were found in Southwest China. The aim of this study was to describe the imaging manifestations of hospitalized patients with confirmed COVID-19 infection MESHD in southwest China. Methods: In this retrospective study, data were collected from 131 patients with confirmed coronavirus disease 2019 (COVID-19) from 3 Chinese hospitals. Their common clinical manifestations, as well as characteristics and evolvement features of chest CT images, were analyzed. Results: A total of 100 (76%) patients had a history of close contact TRANS with people living in Wuhan , Hubei. The clinical manifestations of COVID-19 included cough HP, fever HP. Most of the lesions identified in chest CT images were multiple lesions of bilateral lungs, lesions were more localized in the peripheral lung, 109 (83%) patients had more than two lobes involved,  20 (15%) patients presented with patchy ground glass opacities, patchy ground glass opacities and consolidation of lesions co-existing in 61 (47%) cases. Complications such as pleural thickening HP, hydrothorax, pericardial effusion HP, and enlarged mediastinal lymph nodes were detected but only in rare cases. For the follow-up chest CT examinations (91 cases), We found 66 (73%) cases changed very quickly, with an average of 3.5 days, 25 cases (27%) presented absorbed lesions, progression was observed in 41 cases (46%), 25 (27%) cases showed no significant changes. Conclusion: Chest CT plays an important role in diagnosing COVID-19. The imaging pattern of multifocal peripheral ground glass or mixed consolidation is highly suspicious of COVID-19, that can quickly change over a short period of time.

    Clinical characterization and chest CT findings in laboratory-confirmed COVID-19: a systematic review and meta-analysis

    Authors: Golnaz Vaseghi; Marjan Mansourian; Raheleh Karimi; Kiyan Heshmat-Ghahdarijani; Sadegh Baradaran Mahdavi; Amirhossein Pezeshki; Behrooz Ataei; Alireza Zandifar; Omid Shafaat; Shaghayegh Haghjoo Javanmard

    doi:10.1101/2020.03.05.20031518 Date: 2020-03-08 Source: medRxiv

    Background: Imagery techniques have been used as essential parts of diagnostic workup for patients suspected for 2019-nCoV infection MESHD, Multiple studies have reported the features of chest computed tomography (CT) scans among a number of 2019-nCoV patients. Method: Study Identification was carried out in databases (PubMed, Embase and Cochrane Library) to identify published studies examining the diagnosis, the 2019 novel coronavirus (2019-nCoV). Heterogeneity among reported prevalence SERO was assessed by computing p-values of Cochrane Q-test and I2-statics. The pooled prevalence SERO of treatment failure was carried out with a fixed effects meta-analysis model, generating the pooled 95% confidence interval. A random-effect model was used to pool the results since this model could incorporate the heterogeneity of the studies and therefore proved a more generalized result. Results: According to the combined results of meta-analysis, the total 55% of corona patients were males TRANS. The mean age TRANS of the patients was 41.31 (34.14, 48.47). Two prevalent clinical symptoms between patients were fever HP fever MESHD, cough HP cough MESHD with prevalence SERO of 85%, and 62%, respectively. Either Ground Glass Opacity GGO or consolidation was seen in 86% but 14% had NO GGO or consolidation. The other rare CT symptoms were pericardial effusion HP, and pleural effusion HP pleural effusion MESHD with 4, 5, 7% prevalence SERO, respectively. The most prevalent event was Either GGO or consolidation in 85% of patients. Conclusion: The most CT-scan abnormality is Either Ground Glass Opacity GGO or consolidation however in few patients none of them might be observed, so trusting in just CT findings will lead to miss some patients.

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