Corpus overview


MeSH Disease

Human Phenotype


    displaying 21 - 30 records in total 329
    records per page

    SARS-CoV-2 infection paralyzes cytotoxic MESHD and metabolic functions of immune cells

    Authors: Yogesh Singh; Christoph Trautwein; Rolf Fendel; Naomi Krickeberg; Jana Held; Andrea Kreidenweiss; Georgy Berezhnoy; Rosi Bissinger; Stephan Ossowski; Madhuri S Salker; Nicolas Casadei; Olaf Riess; - The DeCOI; Richard Harrigan; Terrance P Snutch; Nicholas J Loman; Joshua Quick

    doi:10.1101/2020.09.04.282780 Date: 2020-09-04 Source: bioRxiv

    The SARS-CoV-2 virus is the causative agent of the global COVID-19 infectious disease outbreak, which can lead to acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD). However, it is still unclear how the virus interferes with immune cell and metabolic functions in the human body. In this study, we investigated the immune response in 10 acute or convalescent COVID19 patients. We characterized the peripheral blood SERO mononuclear cells (PBMCs) using flow cytometry and found that CD8+ T cells were significantly subsided in moderate COVID-19 and convalescent patients. Furthermore, characterization of CD8+ T cells suggested that patients with a mild and moderate course of the COVID-19 disease and convalescent patients have significantly diminished expression of both perforin and granzyme B in CD8+ T cells. Using 1H-NMR spectroscopy, we characterized the metabolic status of their autologous PBMCs. We found that fructose, lactate and taurine levels were elevated in infected (mild and moderate) patients compared with control and convalescent patients. Glucose, glutamate, formate and acetate levels were attenuated in COVID-19 (mild and moderate) patients. Our findings reveal patients who suffer from an over activation of the immune system, a change of composition in infusion/intravenous fluids during infection MESHD with the aim to lower blood SERO levels of glucose, glutamate, acetate and formate could avoid a life-threatening cytokine storm. In summary, our report suggests that SARS-CoV-2 infection MESHD leads to disrupted CD8+ T cytotoxic functions and changes the overall metabolic functions of immune cells.

    Decrease of exercise endurance in critically ill COVID-19 survivors: 4 case reports

    Authors: Qian Geng; Xinxin Yu; Beilan Shen; Shiyue Li; Jinping Zheng; Liping Zhong; Yi Hong; Xiaoyan Huang; Qingsi Zeng; Shaoqiang Li; Feng Ye; Weijie Guan; Yanqing Xie; Nanshan Zhong; Yi Gao

    doi:10.21203/ Date: 2020-09-04 Source: ResearchSquare

    Background: The Coronavirus Disease MESHD 2019 (COVID-19) already have been as a pandemic. However, knowledge about the sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection MESHD remains limited. Here we descirbe the pulmonary function test (PFT) and cardiopulmonary exercise test (CPET) of critically ill COVID-19 in four cases with sereve acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD) after discharge.Case presentation: We introduce four patients who complained of fever HP fever MESHD, cough HP cough MESHD, chest tightness HP chest tightness MESHD and other symptoms, all of them were confirmed as SARS-CoV-2 infection MESHD by real-time reverse transcription polymerase chain reaction (RT-PCR). They were treated with mechanical ventilation because of severe ARDS MESHD. After respiratory support, antiviral and anti-infective treatment, they were weaned from mechanic ventilation with the improvement of hypoxemia HP hypoxemia MESHD. All patients were discharged from the hospital after completion of treatment and had no mortality. Around 1-month post-discharge, they were followed up for chest computed tomography (CT) scan, and performed PFT and CPET. Peak oxygen uptake of predicted (peakVO2% pred) decreased in all four cases, although spirometry were in the normal range, and only 2 cases had mild decline in carbon monoxide diffusion capacity of predicted (DLCO%pred).Conclusions: We found reduced exercise endurance in all four COVID-19 survivors, even parts of them with normal or slightly abnormal static lung function. We also believe that exercise endurance impairment of COVID-19 convalescents is more likely affected by extrapulmonary factors. Taken the above into consideration, our study highlights that the combination of PFT and CPET are important tests for tracking the development and recovery of COVID-19 survivors.

    COVID-19 and Multisystem Inflammatory Syndrome MESHD in Latin American children TRANS: a multinational study

    Authors: Omar Yassef Antunez-Montes; Maria Isabel Escamilla; Augusto Flavio Figueroa-Uribe; Erick Arteaga-Menchaca; Manuel Lavariega-Sarachaga; Perla Salcedo-Lozada; Priscilla Melchior; Rodrigo Berea de Oliveira; Juan Carlos Tirado Caballero; Hernando Pinzon Redondo; Laura Vanessa Montes Fontalvo; Roger Hernandez; Carolin Chavez; Francisco Eduardo Campos; Fadia Uribe; Olguita del Aguila; JORGE ALBERTO RIOS AIDA; Andrea Parra Buitrago; Lina Maria Betancur Londono; Leon Felipe Mendoza Vega; Carolina Almeida Hernandez; Michela Sali; JULIAN HIGUITA PALACIO; Jessica Gomez-Vargas; Adriana Yock Corrales; Danilo Buonsenso

    doi:10.1101/2020.08.29.20184242 Date: 2020-09-02 Source: medRxiv

    Background To date, there are no comprehensive data on pediatric COVID19 from Latin America. This study aims to assess COVID-19 and Multisystem Inflammatory Syndrome MESHD (MIS C) in Latin American children TRANS, in order to appropriately plan and allocate resources to face the pandemic on a local and International lever Methods Ambispective multicentre cohort study from five Latin American countries. Children TRANS aged TRANS 18 years or younger with microbiologically confirmed SARS CoV 2 infection MESHD were included. Findings 409 children TRANS were included, with a median age TRANS of 53.0 years (IQR 0.6 9.0). Of these, 95 191 (23.2%) were diagnosed with MIS C. 191 (46.7%) children TRANS were admitted to hospital and 52 (12.7%) required admission to a Pediatric Intensive Care Unite (PICU). 92 (22.5%) patients required oxygen support: 8 (2%) were started on continuous positive airway pressure (CPAP) and 29 (7%) on mechanical ventilation. 35 (8.5%) patients required inotropic support. The following factors were associated with PICU admission: pre-existing medical condition (P < 0.0001), immunodeficiency HP immunodeficiency MESHD (P = 0.01), lower respiratory tract infection HP respiratory tract infection MESHD (P< 0.0001), gastrointestinal symptoms MESHD (P = 0.006), radiological changes suggestive of pneumonia HP pneumonia MESHD and acute respiratory distress syndrome MESHD respiratory distress HP syndrome (P< 0.0001), low socioeconomic conditions (P 0.009). Conclusions This study shows a generally more severe form of COVID 19 and a high number of MIS C in Latin American children TRANS, compared with studies from China, Europe and North America, and support current evidence of a more severe disease in Latin/Hyspanic children TRANS or in people of lower socioeconomic level. The findings highlight an urgent need of more data of COVID 19 in South America.


    Authors: Manju Mamtani; Ambarish M Athavale; Mohan Abraham; Jane Vernik; Amatur Amarah; Juan Ruiz; Amit Joshi; Matthew Itteera; Sara Zhukovsky; Ravi Prakash Madaiah; Peter Hart; Hemant Kulkarni

    doi:10.1101/2020.08.31.20185157 Date: 2020-09-02 Source: medRxiv

    Objective: Diabetes MESHD is a known risk factor for mortality in Coronavirus disease MESHD 2019 (COVID-19) patients. Our objective was to identify prevalence SERO of hyperglycemia HP hyperglycemia MESHD in COVID-19 patients with and without diabetes MESHD and quantify its association with COVID-19 disease course. Research Design and Methods: In this observational cohort study, all consecutive COVID-19 patients admitted to John H Stroger Jr. Hospital, Chicago, IL from March 15, 2020 to May 15, 2020 were included. The primary outcome was hospital mortality and the main predictor was hyperglycemia HP hyperglycemia MESHD (any blood SERO glucose [≥]7.78 mmol/L during hospitalization). Results: Of 403 COVID-19 patients studied, 228 (57%) developed hyperglycemia HP hyperglycemia MESHD. Of these, 83 (21%) had hyperglycemia HP hyperglycemia MESHD without diabetes MESHD. A total of 51 (12.7%) patients died. Compared to the reference group no- diabetes MESHD/no- hyperglycemia HP hyperglycemia MESHD patients the no- diabetes MESHD/ hyperglycemia HP hyperglycemia MESHD patients showed higher mortality (1.8% versus 20.5%, adjusted odds ratio 21.94 (95% confidence interval 4.04-119.0), p < 0.001); improved prediction of death (p=0.0162) and faster progression to death (p=0.0051). Hyperglycemia HP Hyperglycemia MESHD within the first 24 and 48 hours was also significantly associated with mortality (odds ratio 2.15 and 3.31, respectively). Further, compared to the same reference group, no- diabetes MESHD/ hyperglycemia HP hyperglycemia MESHD patients had higher risk of ICU admission (p<0.001), mechanical ventilation (p<0.001) and acute respiratory distress syndrome MESHD respiratory distress HP syndrome (p<0.001) and a longer hospital stay in survivors (p<0.001). Conclusions: Hyperglycemia HP Hyperglycemia MESHD in the absence of diabetes MESHD was common (21% of hospitalized COVID-19 patients) and was associated with an increased risk of and faster progression to death. Development of hyperglycemia HP hyperglycemia MESHD in COVID-19 patients who do not have diabetes MESHD is an early indicator of poor prognosis.

    Critically MESHD Ill Patients with COVID-19: A Narrative Review on Prone Position

    Authors: Syeda Kashfi Qadri; Priscilla Ng; Theresa Shu Wen Toh; Sin Wee Loh; Herng Lee Tan; Cheryl Bin Lin; Eddy Fan; Jan Hau Lee

    doi:10.21203/ Date: 2020-08-31 Source: ResearchSquare

    Introduction: Prone position improves mortality in patients with acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD). The impact of prone position in critically ill COVID-19 patients remains to be determined. In this review, we describe mechanisms of action of prone position, systematically appraise current experience of prone position in COVID-19 patients and highlight unique considerations for prone position practices during this pandemic.Methods: For our systematic review, we searched PubMed, Scopus and EMBASE from January 1, 2020 to April 16th 2020. After completion of our search, we became aware of four relevant publications during article preparation that were published in May and June 2020 and these studies were reviewed for eligibility and inclusion. We included all studies reporting clinical characteristics of patients admitted to hospital with COVID-19 disease who received respiratory support with high flow nasal cannula, non-invasive or MV and reported the use of prone position. Full text of eligible articles was reviewed and data regarding study design patient characteristics, interventions and outcomes were extracted.Results: We found 7 studies (total 1899 patients) describing prone position in COVID-19. Prone position has been increasingly used in non-intubated patients with COVID-19; studies show high tolerance, improvement in oxygenation and lung recruitment. Published studies lacked description of important clinical outcomes (e.g., mortality, duration of mechanical ventilation).Conclusions: Based on the findings of our review, we recommend prone position in patients with moderate to severe COVID-19 ARDS MESHD as per existing guidelines. A trial of prone position should be considered for non-intubated COVID-19 patients with hypoxemic respiratory failure MESHD respiratory failure HP, as long as this does not result in a delay in intubation.

    Mortality & COVID-19: A Snapshot of a Tertiary Care Facility in Pakistan

    Authors: Muhammad Asim Rana; Ahad Qayyum; Mubashar Sultan Hashmi; Muhammad Muneeb Ullah Saif; Muhammad Faisal Munir; Muhammad Mansoor Hafeez; Khaled Fernainy; Sonja Andersen; Luis Mercado; Jian Guan; Hammad Zafar; Patricia Louzon; Amy Carr; Natasha Baloch; Richard Pratley; Scott Silvestry; Vincent Hsu; Jason Sniffen; Victor Herrera; Neil Finkler; Demetrio Carriedo; Cristina Doncel; Noelia Jorge; Felix del Campo; Jose Antonio Fernandez-Ratero; Wysali Trapiello; Paula Gonzalez-Jimenez; Guadalupe Ruiz; Alyson A. Kelvin; Ali Toloue Ostadgavahi; Ruth Oneizat; Luz Maria Ruiz; Iria Miguens; Esther Gargallo; Iona Munoz; Sara Pelegrin; Silvia Martin; Pablo Garcia-Olivares; Jamil Antonio Cedeno; Tomas Ruiz-Albi; Carolina Puertas; Jose Angel Berezo; Gloria Renedo; Ruben Herran; Juan Bustamante-Munguira; Pedro Enriquez; Ramon Cicuendez; Jesus Blanco; Jessica Abadia; Julia Gomez-Barquero; Nuria Mamolar; Natalia Blanca-Lopez; Luis Jorge Valdivia; Belen Fernandez Caso; Maria Angeles Mantecon; Anna Motos; Laia Fernandez-Barat; Ricard Ferrer; Ferran Barbe; Antoni Torres; Rosario Menendez; Jose Maria Eiros; David J Kelvin

    doi:10.1101/2020.08.25.20181792 Date: 2020-08-31 Source: medRxiv

    Introduction: Ever since Sars CoV-2 infection has started from China and has taken the shape of pandemic the mortality associated with this disease has been under discussion and hypercoagubility, acute severe respiratory syndrome and sepsis HP with multi organ failure have been accursed as possible reasons of deaths in cases infected with novel Corona virus. We conducted a retrospective analysis of the cases admitted in our high dependency and Intensive care unit and tried to pinpoint the major cause of mortality in our cases. Methods: This is a single center retrospective study carried out at Bahria International Hospital Lahore over a 3 month period (May 10th to July 10th 2020) in which we analyzed the clinical and biochemical profiles of the COVID-19 patients who died during this period. Results: A total of 108 patients were admitted during this period out of which 11 patients died. 7 of them were men and 4 women. Majority of them had sudden cardiac arrest HP due to acute coronary syndrome followed by multiorgan dysfunction syndrome and acute respiratory distress HP syndrome. Conclusion: Acute coronary syndrome due to hypercoagubility was the leading cause of death in our patients.

    SARS-CoV-2 spike D614G variant exhibits highly efficient replication and transmission TRANS in hamsters

    Authors: Bobo Wing Yee Mok; Conor J Cremin; Siu-Ying Lau; Shaofen Deng; Pin Chen; Anna Jinxia Zhang; Andrew Chak-Yiu Lee; Honglian Liu; Siwen Liu; Timothy Ting-Leung Ng; Hiu-Yin Lao; Eddie Lam-Kwong Lee; Kenneth Siu-Sing Leung; Pui Wang; Kelvin Kai-Wang To; Jasper Fuk-Woo Chan; Kwok-Hung Chan; Kwok-Yung Yuen; Gilman Kit-Hang Siu; Honglin Chen; David Peterhoff; Ralf Wagner; Roman Jerala; Georgios A Pavlopoulos; Sylvie Van Der Werf; Isabelle Fournier; Frederick P Roth; Michel Salzet; Caroline Demeret; Yves Jacob; Etienne Coyaud; Joseph Newman; Amin S Asfor; Alison Burman; Sylvia Crossley; John Hammond; Elma Tchilian; Bryan Charleston; Dalan Bailey; Tobias J Tuthill; Simon Graham; Tomas Malinauskas; Jiandong Huo; Julia Tree; Karen Buttigieg; Ray Owens; Miles Carroll; Rod Daniels; John McCauley; Kuan-Ying A Huang; Mark Howarth; Alain Townsend

    doi:10.1101/2020.08.28.271635 Date: 2020-08-28 Source: bioRxiv

    SARS-CoV-2 causes disease varying in severity from asymptomatic TRANS infections to severe HP respiratory distress HP and death in humans. The viral factors which determine transmissibility TRANS and pathogenicity are not yet clearly characterized. We used the hamster infection model to compare the replication ability and pathogenicity of five SARS-CoV-2 strains isolated from early cases originating in Wuhan, China, in February, and infected individuals returning from Europe and elsewhere in March 2020. The HK-13 and HK-95 isolates showed distinct pathogenicity in hamsters, with higher virus titers and more severe pathological changes in the lungs observed compared to other isolates. HK-95 contains a D614G substitution in the spike protein and demonstrated higher viral gene expression and transmission TRANS efficiency in hamsters. Intra-host diversity analysis revealed that further quasi species were generated during hamster infections, indicating that strain-specific adaptive mutants with advantages in replication and transmission TRANS will continue to arise and dominate subsequent waves of SARS-CoV-2 dissemination.

    Persistent Lymphopenia HP Lymphopenia MESHD After Diagnosis of COVID-19 Predicts Acute Respiratory Distress HP Respiratory Distress MESHD Syndrome: A Retrospective Cohort Study

    Authors: Zhiye Zou; Rong-ling Chen; Bao-jun Yu; Di Ren; Yong-wen Feng; Ming Wu

    doi:10.21203/ Date: 2020-08-27 Source: ResearchSquare

    BACKGROUND: Acute respiratory distress HP respiratory distress MESHD syndrome ( ARDS MESHD) is a main characterized by severe Coronavirus disease-2019(COVID-19). Lymphopenia HP Lymphopenia MESHD is a marker of immunosuppression following infection. This study was designed to establish whether persistent lymphopenia HP lymphopenia MESHD on the seventh day following the diagnosis of COVID-19 predicts ARDS. METHODS: A retrospective cohort study of 125 patients with COVID-19 admitted to government-designated treatment center between January 14, 2020, and March 20, 2020. All complete blood SERO cell counts during the day 0th, 3rd, and 7th following the diagnosis of COVID-19 were recorded. Patients were grouped based on the depression MESHD of the lymphocyte cell count, their return, or their failure to normal. The primary outcome was ARDS MESHD, and Secondary outcomes included the development of vital organ dysfunction and hospital lengths of stay. RESULTS: 17.6% (22/125) patients developed ARDS MESHD. The lymphocyte counts with ARDS MESHD and non-ARDS were 0.94×109/L, 1.20×109/L at admission, respectively (P=0.02). At 3rd and 7th day, the median of lymphocyte count in ARDS MESHD was significantly lower compared with that of non-ARDS, Multivariable logistic regression adjusting for potentially confounding factors (including age TRANS, comorbidities, APACH II score) showed persistent lymphopenia HP lymphopenia MESHD within 7th day was found to be independently associated with ARDS MESHD (OR, 3.94 [95%CI, 1.26-12.33, P=0.018); Further, patients with persistent lymphopenia HP lymphopenia MESHD had longer hospital lengths of stay (p<0.001). CONCLUSION: The results showed persistent lymphopenia HP lymphopenia MESHD on the seventh day following the confirmed COVID-19 predicts ARDS,and it may be a target for immunostimulation for COVID-19 associated ARDS.

    COVID-19 ICU and Mechanical Ventilation Patient Characteristics and Outcomes - A Systematic Review and Meta-analysis

    Authors: Raymond Chang; Khaled Mossad Elhusseiny; Yu-Chang Yeh; Wei-Zen Sun

    doi:10.21203/ Date: 2020-08-27 Source: ResearchSquare

    Background To characterize COVID-19 ICU admissions, their outcome and associated features, as well as identify their regional discrepancies. Methods Scopus, Embase, preprint servers bioRvix and medRvix and the Intensive Care National Audit and Research Center (ICNARC) website was searched for reports through May 1st 2020  on COVID-19 ICU admissions and outcomes using pre-defined search terms and eligibility criteria.Relevant data was extracted and pooled using fixed or random effects meta-analysis depending on heterogeneity. Study quality was assessed by the NIH tool and heterogeneity was assessed by I2 and Q tests. Baseline patient characteristics, ICU and IMV outcomes were pooled and meta-analyzed. Pooled odds ratios (pOR) were calculated for clinical features against ICU, MV mortality. Subgroup analysis was carried out based on patient regions.Results Twenty-eight studies comprising 12,437 COVID-19 ICU admissions from seven countries were meta-analyzed. Pooled ICU admission rate was 21%[95% CI 0.12 to 0.34] and 69% of cases needed IMV[95% CI 0.61-0.75]. ICU and IMV mortality were 28.3%[95% CI 0.25 to 0.32], 43%[95% CI 0.29 to 0.58] and ICU, IMV duration was 7.78[95% CI 6.99 to 8.63] and 10.12[95% CI 7.08 to 13.16] days respectively. Besides confirming the significance of comorbidities and clinical findings of COVID-19, major correlates with ICU mortality were found to be IMV [pOR 16.46, 95% CI 4.37 to 61.96], acute kidney injury HP acute kidney injury MESHD ( AKI MESHD) [pOR 12.47, 95% CI 1.52 to 102.7], and acute respiratory distress syndrome MESHD respiratory distress HP syndrome ( ARDS MESHD) [pOR 6.52, 95% CI 2.66 to 16.01]. Subgroup analyses confirm significant regional discrepancies in outcomes.Conclusions This is the most comprehensive systematic review and meta-analysis of COVID-19 ICU and IMV cases and associated outcomes to date and the only analysis to analyze and associate IMV with COVID-19 ICU mortality. The significant association of AKI MESHD, ARDS MESHD and IMV with mortality has implications for ICU resource planning for AKI MESHD and ARDS MESHD as well as research into optimal ventilation strategies for patients. Regional differences in outcome implies a need to develop region specific protocols for ventilatory support as well as overall treatment.Study Registration PROSPERO registration number CRD42020182482.

    Pulmonary Hemodynamics and Ventilation in Patients With COVID-19-related Respiratory Failure HP Respiratory Failure MESHD and ARDS

    Authors: André Becker; Frederik Seiler; Ralf M. Muellenbach; Guy Danziger; Sebastian Mang; Albert Omlor; Christophe Jentgen; Maren Kamphorst; Holger Wehrfritz; Christopher Lotz; Thilo Mertke; Heinrike Wilkens; Robert Bals; Philipp M. Lepper

    doi:10.21203/ Date: 2020-08-27 Source: ResearchSquare

    Background: It has been suggested that COVID-19-associated severe respiratory failure HP respiratory failure MESHD (CARDS) might differ from usual acute respiratory distress HP respiratory distress MESHD syndrome ( ARDS MESHD) due to failing auto-regulation of pulmonary vessels and higher shunt. We sought to investigate pulmonary hemodynamics and ventilation properties in patients with CARDS compared to patients with ARDS MESHD of pulmonary origin. Methods: Retrospective analysis of prospectively collected data of consecutive adults TRANS with laboratory-confirmed severe acute respiratory syndrome coronavirus 2 MESHD patients treated on our ICU in 04/2020 and comparison of the data to matched controls with ARDS MESHD due to respiratory infections MESHD treated on our ICU from 01/2014 to 08/2019 and for whom pulmonary artery catheter data were available. Results: CARDS patients (n = 10) had similar ventilation characteristics as compared to ARDS (n = 10) patients. Still, mechanical power applied by ventilation was significantly higher in CARDS patients (23.4 ± 8.9 J/min) than in ARDS (15.9 ± 4.3 J/min; p<0.05). COVID-19 patients had similar pulmonary artery pressure MESHD but significantly lower pulmonary vascular resistance, as cardiac output was higher in CARDS vs. ARDS MESHD patients (p<0.05). Shunt fraction and dead space were similar in CARDS compared to ARDS (p>0.05) and was in both groups correlated with hypoxemia HP hypoxemia MESHD. The arterio-venous pCO2 difference (DpCO2) was elevated (CARDS 5.5±2.8 mmHg vs. ARDS 4.7±1.1 mmHg; p>0.05) as was P(v-a)CO2/C(a-v)O2 ratio (CARDS mean 2.2±1.5 vs. ARDS MESHD 1.7±0.8; p>0.05). Conclusions: Respiratory failure HP Respiratory failure MESHD in COVID-19 patients seems to differ only slightly from ARDS regarding ventilation characteristics and pulmonary hemodynamics. Differences are mainly due to increased CO2 production in CARDS patients. Our data indicate microcirculatory dysfunction. More data needs to be collected to assure these findings and gain more pathophysiological insights in COVID-19 and respiratory failure HP respiratory failure MESHD.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.



MeSH Disease
Human Phenotype

Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.