Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Radiological findings in low dose CT for COVID-19 pneumonia HP pneumonia MESHD in 182 patients: correlation of signs and severity with patient outcome

    Authors: Charlotte M. Biebaû, M.D.; Jeroen N. Desmet, M.D.; Adriana Dubbeldam, M.D.; Lesley Cockmartin, MSc Ph.D.; Walter M Coudyzer, MSc; Johan Coolen, M.D. Ph.D.; Johny A Verschakelen, M.D. Ph.D.; Walter De Wever, M.D. Ph.D.

    doi:10.21203/rs.3.rs-69889/v1 Date: 2020-09-01 Source: ResearchSquare

    OBJECTIVESTo characterize CT-findings of COVID-19 pneumonia HP pneumonia MESHD and their value in diagnosis and outcome prediction.METHODSChest CTs of 182 patients with a confirmed diagnosis of COVID-19 infection by RT-PCR were evaluated for the presence of CT-abnormalities and their frequency. Regarding the patient outcome each patient was categorized in 5 progressive stages and the duration of hospitalization was determined. Regression analysis was performed to find which CT findings are predictive for patient outcome and to assess prognostic factors for the hospitalization duration.RESULTSMultivariate statistical analysis confirmed a higher age TRANS (OR= 1.023, p= 0.025), a higher total visual severity score (OR= 1.038, p= 0.002) and the presence of crazy paving (OR= 2.160, p= 0.034) as predictive parameters for patient outcome. A higher total visual severity score (+ 0.134 days; p= 0.012) and the presence of pleural effusion HP pleural effusion MESHD (+ 13.985 days, p= 0.005) were predictive parameters for a longer hospitalization duration.CONCLUSIONSAn increasing percentage of lung opacity MESHD as well as the presence of crazy paving and a higher age TRANS are associated with a worse patient outcome. The presence of a higher total visual severity score and pleural effusion HP pleural effusion MESHD are significant predictors for a longer hospitalization duration.

    Lung ultrasound findings in pediatric patients with COVID-19.

    Authors: Carmina Guitart; Ricardo Suárez; Mònica Girona; Sara Bobillo-Pérez; Lluïsa Hernández; Mònica Balaguer; Francisco José Cambra; Iolanda Jordan

    doi:10.21203/rs.3.rs-58977/v1 Date: 2020-08-13 Source: ResearchSquare

    During the pandemic caused by the novel coronavirus (COVID-19), lung ultrasound has been used to diagnose and monitor respiratory condition. The aim of the study was to describe lung ultrasound findings in children TRANS with a COVID-19 infection MESHD. Patients younger than 18 years old and positive for COVID-19, admitted to pediatric tertiary referral hospital were included. They were divided into two groups depending on the presence of respiratory symptoms. Lung ultrasound results were categorized into three degrees of aeration loss: normal, moderate, and severe; and into three patterns: viral or bacterial pneumonia MESHD pneumonia HP, and atelectasis HP.Sixteen patients were recruited. The median age TRANS was 11 years old (IQR 2.8-12). Four children TRANS (25%) required admission to the intensive care unit. Six patients (37.5%) presented with respiratory symptoms. All of them (100%) showed moderate-to-severe aeration loss on lung ultrasound. A viral pneumonia HP pneumonia MESHD pattern was observed in four cases (66.6%). Ten patients (62.5%) presented with non-respiratory symptoms, lung ultrasound showed moderate-to-severe aeration loss in nine (90%). Three (30%) were diagnosed of multisystem inflammatory syndrome MESHD and lung MESHD ultrasounds showed severe aeration loss and bilateral pleural effusion MESHD pleural effusion HP.Conclusions: Children TRANS with COVID-19 and respiratory symptoms showed a viral pneumonia HP pneumonia MESHD pattern with moderate-to-severe aeration loss upon the lung ultrasound assessment.

    Clinical Severity and CT Features of the COVID-19 Pneumonia HP: Focus on CT Score and Laboratory Parameters

    Authors: Jianghui Duan; Kunsong Su; Hongliang Sun; Yanyan Xu; Liangying Liu

    doi:10.21203/rs.3.rs-45453/v1 Date: 2020-07-18 Source: ResearchSquare

    Background: Although CT characteristics of Coronavirus Disease MESHD 2019 (COVID-19) pneumonia HP pneumonia MESHD between patients with mild and severe forms of the disease have already been reported in the literature, there was little attention to the correlation of imaging features and laboratory testing. We aimed to compare the laboratory and chest CT imaging features in patients with COVID-19 pneumonia HP pneumonia MESHD between non-severe cases and severe cases, and to analyze the correlation of CT score and laboratory testing.Methods: This study consecutively included 54 patients with COVID-19 pneumonia HP pneumonia MESHD (26 males TRANS and 28 females TRANS, 26 to 92 years of age TRANS, 43 cases with non-severe and 11 cases with severe group). Clinical, laboratory and image data were collected between two subgroups. A CT score system was used to evaluate the extent of disease. Correlation between the CT score and laboratory data were estimated. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance SERO of CT score and laboratory tests.Results: Compared with non-severe patients, severe patients had showed increased white blood SERO cell count, neutrophil count, neutrophil percentage, the neutrophil-to-lymphocyte ratio (NLR) and decreased lymphocyte percentage (all p < 0.05). Architectural distortion, pleural effusion HP pleural effusion MESHD, air bronchogram and consolidation-dominant pattern were more common in the severe group (all p < 0.05). CT score of the severe group was higher than the non-severe group (p < 0.001). For distribution characters of the lesions, diffuse pattern in the transverse distribution was more often seen in the severe group (p < 0.001). CT score was positively correlated with the white blood SERO cell counts, neutrophil counts, the percent of neutrophil, NLR, alanine aminotransferase, lactate dehydrogenase and C-reactive protein, and was inversely related to the lymphocyte, the percent of lymphocyte. ROC analysis showed that when the optimal threshold of CT score was 13, the area under the curve was the largest, which was 0.855, and the sensitivity SERO and specificity were 100% and 60% respectively for the diagnosis of the severe patients.Conclusion: CT score showed significant correlations with laboratory inflammatory markers, suggesting that chest CT and laboratory examination maybe provide a better reference for clinicians to judge the severity of diseases.

    Sensitivity SERO of Lung US compared to Chest CT for the screening of COVID-19: preliminary report of our experience

    Authors: Carla Maria Irene Quarato; Antonio Mirijello; Donato Lacedonia; Mariapia Venuti; Raffaele Russo; Michele Maria Maggi; Gaetano Rea; Anna Simeone; Beatrice Ferragalli; Salvatore De Cosmo; Marco Sperandeo

    doi:10.21203/rs.3.rs-40937/v1 Date: 2020-07-10 Source: ResearchSquare

    As lung ultrasound (LUS) is a noninvasive, radiation-free, repeatable and portable imaging tool suitable for a point-of-care use, several recent literature reports have emphasized its role as the ideal screening tool for SARS-CoV2 pneumonia HP. To evaluate the actual diagnostic accuracy of LUS for this purpose, we performed a systematic comparative study between LUS and CT scan findings in a population of 82 patients hospitalized because of COVID-19. LUS and Chest CT have been performed in all patients within 6-12 hours from the admission. The sensitivity SERO of LUS in assessing typical CT findings was 60%. Despite LUS detected consolidations adherent to pleural surface in all cases, it was not able to detect all the consolidations assessed at CT scan (p=0.002), showing a risk to underestimate the actual disease’s extent. Moreover, only 70% of pleural surface is visible by LUS. Considering that the specificity and the positive predictive value SERO of the same LUS signs may be lowered in a normal setting of non epidemic COVID-19 and in case of pre-existing cardio-pulmonary diseases, LUS use should not be indicated for diagnosis of COVID-19. However, it may be very useful for the assessment of pleural effusion HP and to guide safer fluid drainage.

    Lung Ultrasound Findings in Patients Hospitalized with Covid-19

    Authors: Andre D Kumar; Sukyung Chung; Youyou Duanmu; Sally Graglia; Farhan Lalani; Kavita Gandhi; Viveta Lobo; Trevor Jensen; Yingjie Weng; Jeffrey Nahn; John Kugler

    doi:10.1101/2020.06.25.20140392 Date: 2020-06-28 Source: medRxiv

    Introduction: Point-of-care ultrasound (POCUS) has the potential to transform healthcare delivery in the era of COVID-19 with its diagnostic and therapeutic expediency. It can be performed by clinicians already at the bedside, which permits an immediate and augmented assessment of a patient. Although lung ultrasound can be used to accurately diagnose a variety of disease states such as pneumothorax HP, pleural effusions HP pleural effusions MESHD, pneumonia HP pneumonia MESHD and interstitial lung disease2, there are limited reports on the sonographic manifestations of COVID-19. There is an urgent need to identify alternative diagnostic modalities that can be immediately employed at the bedside of COVID-19 patients. Methods: This study was conducted at two medical centers in the United States from 3/21/2020-6/01/2020. Any adult TRANS who was hospitalized with COVID-19 (based on symptomatology and a confirmatory RT-PCR for SARS-CoV-2) and received a pulmonary POCUS examination was included. Providers were instructed to use a 12-zone scanning protocol for pulmonary views and save 6 second clips of each lung zone. This study utilized several POCUS devices, including Butterfly IQ, Vave, Lumify, and Sonosite. The collected images were interpreted by the study researchers based on a consensus document developed by the study authors and previously accepted definitions of lung POCUS findings. Results: A total of 22 eligible patients who received 36 lung scans were included in our study. Eleven (50%) patients experienced clinical deterioration (defined as either ICU admission, invasive mechanical ventilation, or death MESHD within 28 days from the initial symptom onset TRANS). Among the 36 lung scans collected, only 3 (8%) were classified as normal. The remaining scans had the following abnormalities: presence of B-lines (n=32, 89%), consolidations (n=20, 56%), pleural thickening HP pleural thickening MESHD (n=17, 47%), and pleural effusion HP pleural effusion MESHD (n=4, 11%). Out of 20 scans with consolidations, 14 (70%) were subpleural and 5 (25%) were translobar. A-lines were present in 26 (72%) of patients, although they were only observed in the majority of the collected lung zones in 5 (14%) of patients. Ultrasound findings were stratified by time from symptom onset TRANS to the scan based on the following time periods: early (0-6 days), middle (7-13 days), and late (14-28 days). B-lines appeared early after symptom onset TRANS and persisted well into the late disease course. In contrast, pleural thickening HP pleural thickening MESHD increased in frequency over time (early: 25%, middle: 47%, late: 67%). Subpleural consolidations also appeared in higher frequency later in the disease course (early: 13%, middle 42%, late: 56%). Discussion: certain lung ultrasound findings may be common in Covid-19, while others may appear later in the disease course or only occur in patients who experience clinical deterioration. Future efforts should investigate the predictive utility of consolidations, pleural thickening HP pleural thickening MESHD and B-lines for clinical deterioration and compare them to traditional radiological studies such as X-rays or CTs.

    Clinical Characteristics of COVID-19 and the Value of Mulbsta Scoring System in Prognosis Evaluation

    Authors: Chao Wang; Zhixiu Luo; Junyi Wu; Jie Zhou; Yahang Lin; Guilin Yan; Manman Yan; Xi Wang; Hanhua Yu; Xiaoyun Zeng

    doi:10.21203/rs.3.rs-35521/v1 Date: 2020-06-14 Source: ResearchSquare

    BackgroundCOVID-19, a worldwideinfectious disease MESHD, has killed more than 420000 people, whichis extremely harmful.MethodsIn this single-center retrospective study, we included the novel coronavirus pneumonia MESHD pneumonia HP confirmed in our hospital. This study collected the basic information andclinical examination features.ResultsThe enrolled 704 patients were affirmed infected with 2019-nCoV by the test of throat swabs. There are 334 men and 369 women, and gender TRANS, age TRANS, combined with basic diseasesare distinct in diverse disease classification (p<0.05). From the symptom analysis, the proportion of fever HP fever MESHD over 38 degrees, dyspnea HP dyspnea MESHD, fatigue HP fatigue MESHD, poor appetite HP and other symptoms is diverse in different types of diseases (p<0.05). As the severity of the disease increases, the median lymphocyte count decreases, C-reactive protein increase, erythrocyte sedimentation rateincrease, albumin decrease, pleural effusion HP pleural effusion MESHD increase, D-Dimer and NT-proBNP increase significantly (p<0.05).As the disease severity increases, the average value of MuLBSTA score obviously ascend (p<0.05), MuLBSTA scoring system predicts novel coronavirus pneumonia MESHD pneumonia HP patients' prognosis is still insufficient, and may require additional indicators including anorexia HP anorexia MESHD, fatigue HP fatigue MESHD, C reactive protein, etc (p<0.05).ConclusionThe MuLBSTA evaluation system has certain value for the evaluation of the disease, but it needs to be improved.

    Pulmonary Thromboembolic Disease MESHD in Patients with COVID-19 Undergoing Computed Tomography Pulmonary Angiography (CTPA): Incidence and Relationship with Pulmonary Parenchymal Abnormalities MESHD

    Authors: Cheng Fang; Giorgio Garzillo; Bhavna Batohi; James T Teo; Marko Berovic; Paul Sidhu; Hasti Robbie

    doi:10.1101/2020.06.01.20118505 Date: 2020-06-02 Source: medRxiv

    Purpose This study aims to report the incidence, severity and extent of pulmonary thromboembolic disease MESHD ( PTD MESHD) in patients with confirmed COVID-19 who have undergone CT pulmonary angiography (CTPA) in a tertiary centre. Materials and Methods This is a retrospective analysis of all patients undergoing CTPA between 23rd March 2020 and 19th April 2020 in a tertiary centre. The presence of PTD MESHD, location and involved pulmonary lobes MESHD were documented. The pattern and extent of pulmonary parenchymal abnormalities MESHD including the presence of fibrosis MESHD, lymph node enlargement MESHD and pleural effusion HP pleural effusion MESHD were evaluated by two experienced observers independently and consensus was achieved for the most disparate results. Inter-observer agreement was assessed using Kappa statistics. Student t-test, Chi square and Mann-Whitney U tests were used to compare imaging features between PTD MESHD and non- PTD MESHD sub-groups. Results During the study period, 2157 patients were confirmed with COVID-19, 297/2157 (13.8%) had CT imaging, 100/2157 (4.6%) were CTPA studies, 93 studies were analysed, excluding sub-optimal studies. Overall incidence of PTD MESHD was 41/93 (44%) with a third of patients showing segmental and subsegmental PTD MESHD (n=28/93, 30%,). D-dimer was elevated in 90/93 (96.8%) of cases. High Wells score did not differentiate between PE and non-PE groups (p=0.801). The inter-observer agreement was fair (Kappa=0.659) for parenchymal pattern and excellent (Kappa = 0.816) for severity. Lymph node enlargement was found in 34/93 of cases (36.6%) with 29/34 (85.3%) showing no additional source of infection MESHD. Fibrosis MESHD was seen in 16/93 (17.2%) of cases, mainly demonstrating fibrotic organising pneumonia HP pneumonia MESHD. Conclusion There is a high incidence of PTD MESHD in COVID -19 patients undergoing CTPA, complicated by lack of a valid risk stratification tool. Our data indicates a much higher suspicion of PTD MESHD is needed in severe COVID-19 patients. The concomitant presence of fibrotic features on CT indicates the need for follow-up for evaluation of chronic pulmonary complications MESHD.

    Comparing Lung CT in COVID-19 Pneumonia HP and Acute Heart Failure MESHD: An Imaging Conundrum

    Authors: Leonardo Paskah Suciadi; Yonathan William; Patricia Jorizal; Vera Nevyta Tarigan; Andreas Hartanto Santoso; Joshua Henrina; Firman Tedjasukmana; Nathania Marliani Kristanti

    id:10.20944/preprints202005.0483.v1 Date: 2020-05-31 Source: Preprints.org

    Background: Lung CT provides an effective modality to evaluate patients with suspected COVID-19. However, overlapping imaging findings with cardiogenic pulmonary oedema MESHD have been reported. Reports comparing lung CT features of these diseases have not been elaborated. Thus, we aimed to investigate these gaps in the knowledge regarding low-dose lung CT features of patients with COVID-19 pneumonia HP pneumonia MESHD with those with acute heart failure MESHD ( HF MESHD). Methods: This retrospective analysis enrolled hospitalized patients with COVID-19 (n=10) and acute heart failure MESHD (n=9) that exclusively underwent low-dose lung CT scans within 24-hours of admission. Clinical and lung CT characteristics were collected and analysed. Results: Ground-glass-opacities (GGO) appearance has been recorded in all subjects in HF MESHD and COVID-19 group. There was no significant statistical difference between the two groups for rounded morphology, consolidation, crazy paving pattern, lesion distribution, parenchymal band (P> 0.05). However, diffuse lesions were more frequent in HF MESHD cases (55.6% vs. 0%) than in COVID-19 pneumonia HP pneumonia MESHD, which had predominantly multifocal pattern. Notably, CT images in HF MESHD patients were more likely to have signs of interstitial tissue thickening such as the interlobular septums, fissures and peribronchovascular interstitium (55.6% vs 0%, 88.9% vs 20% and 44.4% vs 0%,respectively), as well as cardiomegaly HP cardiomegaly MESHD (77.8% vs 0%), increased artery to bronchus ratio (55.6% vs 0%), and pleural effusions HP pleural effusions MESHD (77.8% vs 0%). Conclusions: Major overlaps of lung CT imaging features existed between COVID-19 pneumonia HP pneumonia MESHD and acute HF MESHD cases. However, signs of fluid redistribution are clues that favour HF over COVID-19 pneumonia HP pneumonia MESHD.

    Single-Cell Analysis Reveals Macrophage-Driven T Cell Dysfunction MESHD in Severe COVID-19 Patients

    Authors: Xiaoqing Liu; Airu Zhu; Jiangping He; Zhao Chen; Longqi Liu; Yuanda Xu; Feng Ye; Huijian Feng; Lin Luo; Baomei Cai; Yuanbang Mai; Lihui Lin; Zhekun Zhang; Sibei Chen; Junjie Shi; Lilan Wen; Yuanjie Wei; Jianfen Zhuo; Yingying Zhao; Fang Li; Xiaoyu Wei; Dingbin Chen; Xinmei Zhang; Na Zhong; Yaling Huang; He Liu; Jinyong Wang; Xun Xu; Jie Wang; Ruchong Chen; Xinwen Chen; Nanshan Zhong; Jinxian Zhao; Yimin Li; Jincun Zhao; Jiekai Chen

    doi:10.1101/2020.05.23.20100024 Date: 2020-05-26 Source: medRxiv

    The vastly spreading COVID-19 pneumonia HP pneumonia MESHD is caused by SARS-CoV-2. Lymphopenia HP Lymphopenia MESHD and cytokine levels are tightly associated with disease severity. However, virus-induced immune dysregulation HP at cellular and molecular levels remains largely undefined. Here, the leukocytes in the pleural effusion HP pleural effusion MESHD, sputum, and peripheral blood SERO biopsies from severe and mild patients were analyzed at single-cell resolution. Drastic T cell hyperactivation accompanying elevated T MESHD cell exhaustion was observed, predominantly in pleural effusion HP pleural effusion MESHD. The mechanistic investigation identified a group of CD14+ monocytes and macrophages highly expressing CD163 and MRC1 in the biopsies from severe patients, suggesting M2 macrophage polarization. These M2-like cells exhibited up-regulated IL10, CCL18, APOE, CSF1 (M-CSF), and CCL2 signaling pathways. Further, SARS-CoV-2-specific T cells were observed in pleural effusion HP pleural effusion MESHD earlier than in peripheral blood SERO. Together, our results suggest that severe SARS-CoV-2 infection MESHD causes immune dysregulation HP dysregulation MESHD by inducing M2 polarization and subsequent T cell exhaustion. This study improves our understanding of COVID-19 pathogenesis.

    Lung ultrasound findings in patients with novel SARS-CoV2

    Authors: Mark Evert Haaksma; Micah L.A. Heldeweg; Jorge E. Lopez Matta; Jasper Martijn Smit; Jessica D. van Trigt; Jip Suzanne Nooitgedacht; Carlos V. Elzo Kraemer; Armand R.J. Girbes; Leo M.A. Heunks; David J. van Westerloo; Pieter R. Tuinman

    doi:10.1101/2020.05.18.20105775 Date: 2020-05-21 Source: medRxiv

    Background: Over 2 million people worldwide have been infected with Severe Acute Respiratory Distress Syndrome Corona Virus 2 MESHD Respiratory Distress HP Syndrome Corona Virus 2 ( SARS CoV2 MESHD). Lung ultrasound has been proposed to diagnose and it. However, little is known about ultrasound findings in these patients. Our aim is to present an overview of lung ultrasound characteristics in critically ill patients with SARS CoV2 pneumonia HP pneumonia MESHD overall and in relation to the duration of symptoms and clinical parameters. Methods: On the Intensive Care Unit of two academic hospitals, adult TRANS patients who tested positive for SARS-CoV2 were included. Images were analyzed for pleural MESHD line characteristics, number and appearance of B-lines, BLUE-profiles (Bedside Lung Ultrasound in Emergency), pathology in the PLAPS (Postero Lateral Alveolar MESHD and Pleural Syndrome MESHD) point and a LUS-score (lung ultrasound). The primary outcomes were frequencies, percentages and differences in lung ultrasound findings overall and between short ([≤]14 days) and long (>14 days) duration of symptoms and their correlation with clinical parameters. Results: In this pilot observational study, 61 patients were included with 75 examinations for analysis. The most prevalent ultrasound findings were decreased lung sliding (36%), thickening of the pleural HP pleural MESHD line (42%) and a C-profile per view (37%). Patients with ''long'' duration of symptoms presented more frequently with a thickened and irregular pleural MESHD line (21% (32) vs 9% (11), p=.01), C-profile per patient (47% (18) vs. 25% (8),p=.01) and pleural effusion HP pleural effusion MESHD (19% (14) vs 5% (3),p=.02) compared to patients with short duration of symptoms. Lung ultrasound findings did not correlate with P/F ratio, fluid balance or dynamic compliance, with the exception of the LUS-score and dynamic compliance (R2=0.27, p=.02). Conclusion: SARS CoV2 results in significant ultrasound changes, with decreased lung sliding, thickening of the pleural HP pleural MESHD line and a C-profile being the most observed. With time, a thickened and irregular pleural MESHD line, C-profile and pleural effusion HP pleural effusion MESHD become more common findings.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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