Corpus overview


MeSH Disease

Human Phenotype


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    CT as a Tool to Depict Pulmonary Fibrosis MESHD Pulmonary Fibrosis HP in Patients With COVID-19: a Radiopathological Correlation 

    Authors: Anna Alguersuari; Miguel Angel Carrasco; Gemma Munné; Maria Eulalia Oliva; Cristina Simon; Maria Dolores Bosque; Melcior Martínez; Natalia Lugo; Xavier Herranz; Mariana Rovira

    doi:10.21203/ Date: 2020-07-16 Source: ResearchSquare

    OBJECTIVESCT findings of COVID-19 i nfected MESHDpatients has been well described, but it it’s roll in depicting signs of f ibrosis MESHDin c ritically ill MESHDpatients remains unclear. To our knowledge, there are no radiopathological correlations of the pulmonary pathology. Exudative and proliferative diffuse a lveolar damage MESHD(DAD) are the most commonly reported injury. Few studies describe f ibrosis, MESHD the last phase of DAD. Our study correlates post-mortem chest US and CT findings of COVID-19 i nfected MESHDpatients with the histopathology from biopsies taken of the lung. It focuses on the role of CT to depict f ibrosis. MESHD METHODSThis is a prospective observational study of six consecutive deceased patients infected with COVID-19. Post-mortem chest CTs and US were performed within 24 hours of d eath. MESHD CT and US were used to obtain biopsies of different radiological patterns. Pre-mortem CT examinations were also retrospectively evaluated. RESULTSOn CT, all patients presented with extensive areas of consolidation and ground-glass opacities affecting most segments of the lung. Pleural effusion HP leural effusion MESHDwas present in all cases. Four of the patients showed signs of f ibrosis. MESHD On US, subpleural consolidation, pleural thickening HP leural MESHDthickening, and B-pattern were present.All patients showed different stages of DAD, mostly proliferative DAD. Four patients presented with f ibrotic DAD, MESHD all of which had been admitted for over three weeks and correlated with the CT findings of f ibrosis. MESHD CONCLUSIONIn our study, signs of f ibrosis MESHDon CT show a histopathological correlation. CT may be useful to identify the group of C OVID-infected MESHDpatients that develop f ibrosis MESHDas a marker of poor prognosis, in the late stage of the disease.

    Lung Ultrasound Findings in Patients Hospitalized with Covid-19

    Authors: Andre D Kumar; Sukyung Chung; Youyou Duanmu; Sally Graglia; Farhan Lalani; Kavita Gandhi; Viveta Lobo; Trevor Jensen; Yingjie Weng; Jeffrey Nahn; John Kugler

    doi:10.1101/2020.06.25.20140392 Date: 2020-06-28 Source: medRxiv

    Introduction: Point-of-care ultrasound (POCUS) has the potential to transform healthcare delivery in the era of COVID-19 with its diagnostic and therapeutic expediency. It can be performed by clinicians already at the bedside, which permits an immediate and augmented assessment of a patient. Although lung ultrasound can be used to accurately diagnose a variety of disease states such as pneumothorax HP, pleural effusions HP pleural effusions MESHD, pneumonia HP pneumonia MESHD and interstitial lung disease2, there are limited reports on the sonographic manifestations of COVID-19. There is an urgent need to identify alternative diagnostic modalities that can be immediately employed at the bedside of COVID-19 patients. Methods: This study was conducted at two medical centers in the United States from 3/21/2020-6/01/2020. Any adult TRANS who was hospitalized with COVID-19 (based on symptomatology and a confirmatory RT-PCR for SARS-CoV-2) and received a pulmonary POCUS examination was included. Providers were instructed to use a 12-zone scanning protocol for pulmonary views and save 6 second clips of each lung zone. This study utilized several POCUS devices, including Butterfly IQ, Vave, Lumify, and Sonosite. The collected images were interpreted by the study researchers based on a consensus document developed by the study authors and previously accepted definitions of lung POCUS findings. Results: A total of 22 eligible patients who received 36 lung scans were included in our study. Eleven (50%) patients experienced clinical deterioration (defined as either ICU admission, invasive mechanical ventilation, or death MESHD within 28 days from the initial symptom onset TRANS). Among the 36 lung scans collected, only 3 (8%) were classified as normal. The remaining scans had the following abnormalities: presence of B-lines (n=32, 89%), consolidations (n=20, 56%), pleural thickening HP pleural thickening MESHD (n=17, 47%), and pleural effusion HP pleural effusion MESHD (n=4, 11%). Out of 20 scans with consolidations, 14 (70%) were subpleural and 5 (25%) were translobar. A-lines were present in 26 (72%) of patients, although they were only observed in the majority of the collected lung zones in 5 (14%) of patients. Ultrasound findings were stratified by time from symptom onset TRANS to the scan based on the following time periods: early (0-6 days), middle (7-13 days), and late (14-28 days). B-lines appeared early after symptom onset TRANS and persisted well into the late disease course. In contrast, pleural thickening HP pleural thickening MESHD increased in frequency over time (early: 25%, middle: 47%, late: 67%). Subpleural consolidations also appeared in higher frequency later in the disease course (early: 13%, middle 42%, late: 56%). Discussion: certain lung ultrasound findings may be common in Covid-19, while others may appear later in the disease course or only occur in patients who experience clinical deterioration. Future efforts should investigate the predictive utility of consolidations, pleural thickening HP pleural thickening MESHD and B-lines for clinical deterioration and compare them to traditional radiological studies such as X-rays or CTs.

    CT features of COVID-19 patients with two consecutive negative RT-PCR tests after treatment

    Authors: Zhao Fu; Ningning Tang; Yanqing Chen; Longbai Ma; Youyong Wei; Yumin Lu; Kun Ye; Hang Liu; Fen Tang; Guangyi Huang; Yingxia Yang; Fan Xu

    doi:10.21203/ Date: 2020-06-02 Source: ResearchSquare

    Purpose: The objective of this study is to expound the CT features of COVID-19 patients whose nucleic acid tests converted to negative after treatment.Materials and Methods: We retrospectively reviewed 46 COVID-19 patients with two consecutive negative RT-PCR tests after treatment. The cases were divided into moderate group and severe/critical group according to disease severity. Clinical and CT scanning data were collected. CT signs of pulmonary lesions MESHD and the score of long involvement were expounded.Results: 39 moderate cases and 7 severe/critical cases were included. All moderate patients showed peripheral lesions while severe/critical cases exhibited both central and peripheral lesions with all lobes involvement. Ground glass opacity (GGO) and mixed GGO were observed. Aberrant pulmonary interstitium manifested as reticular and thin linear pattern. Thickened blood SERO vessels and pleural thickening HP pleural thickening MESHD were found. Pulmonary fibrosis HP Pulmonary fibrosis MESHD, annular thickening of the bronchial wall, bronchiectasis HP, air bronchogram and small amount of bilateral pleural effusion MESHD pleural effusion HP were observed in severe/critical patients. The severe/critical group showed higher CT score of involvement.Conclusions: Pulmonary lesions persisted even after twice consecutive nucleic acid tests converted to negative. We strongly recommended regular follow-up of CT scans after nucleic acid tests conversion. Evaluation of complete remission should base on chest CT.

    Lung ultrasound findings in patients with novel SARS-CoV2

    Authors: Mark Evert Haaksma; Micah L.A. Heldeweg; Jorge E. Lopez Matta; Jasper Martijn Smit; Jessica D. van Trigt; Jip Suzanne Nooitgedacht; Carlos V. Elzo Kraemer; Armand R.J. Girbes; Leo M.A. Heunks; David J. van Westerloo; Pieter R. Tuinman

    doi:10.1101/2020.05.18.20105775 Date: 2020-05-21 Source: medRxiv

    Background: Over 2 million people worldwide have been infected with Severe Acute Respiratory Distress Syndrome Corona Virus 2 MESHD Respiratory Distress HP Syndrome Corona Virus 2 ( SARS CoV2 MESHD). Lung ultrasound has been proposed to diagnose and it. However, little is known about ultrasound findings in these patients. Our aim is to present an overview of lung ultrasound characteristics in critically ill patients with SARS CoV2 pneumonia HP pneumonia MESHD overall and in relation to the duration of symptoms and clinical parameters. Methods: On the Intensive Care Unit of two academic hospitals, adult TRANS patients who tested positive for SARS-CoV2 were included. Images were analyzed for pleural MESHD line characteristics, number and appearance of B-lines, BLUE-profiles (Bedside Lung Ultrasound in Emergency), pathology in the PLAPS (Postero Lateral Alveolar MESHD and Pleural Syndrome MESHD) point and a LUS-score (lung ultrasound). The primary outcomes were frequencies, percentages and differences in lung ultrasound findings overall and between short ([≤]14 days) and long (>14 days) duration of symptoms and their correlation with clinical parameters. Results: In this pilot observational study, 61 patients were included with 75 examinations for analysis. The most prevalent ultrasound findings were decreased lung sliding (36%), thickening of the pleural HP pleural MESHD line (42%) and a C-profile per view (37%). Patients with ''long'' duration of symptoms presented more frequently with a thickened and irregular pleural MESHD line (21% (32) vs 9% (11), p=.01), C-profile per patient (47% (18) vs. 25% (8),p=.01) and pleural effusion HP pleural effusion MESHD (19% (14) vs 5% (3),p=.02) compared to patients with short duration of symptoms. Lung ultrasound findings did not correlate with P/F ratio, fluid balance or dynamic compliance, with the exception of the LUS-score and dynamic compliance (R2=0.27, p=.02). Conclusion: SARS CoV2 results in significant ultrasound changes, with decreased lung sliding, thickening of the pleural HP pleural MESHD line and a C-profile being the most observed. With time, a thickened and irregular pleural MESHD line, C-profile and pleural effusion HP pleural effusion MESHD become more common findings.

    Comparison of initial HRCT features of COVID-19 pneumonia HP pneumonia MESHD and other viral pneumonias MESHD pneumonias HP

    Authors: Yilong Huang; Yuanming Jiang; Li Wu; Wenfang Yi; Jiyao Ma; Peng Wang; Ying Xie; Zhipeng Li; Xiang Li; Minchang Hong; Jialong Zhou; Chuwei Duan; Yunhui Yang; Wei Zhao; Feng Yuan; Dan Han; Bo He

    doi:10.21203/ Date: 2020-05-17 Source: ResearchSquare

    Background: Multicenter retrospective comparison of the first high-resolution computed tomography (HRCT) findings of coronavirus disease MESHD 2019 (COVID-19) and other viral pneumonias MESHD pneumonias HP.Methods: We retrospectively collected clinical and imaging data from 254 cases of confirmed TRANS viral pneumonia MESHD pneumonia HP in 20 hospitals in Yunnan Province, China, from March 1, 2015, to March 15, 2020. According to the virus responsible for the pneumonia HP pneumonia MESHD, the pneumonias HP pneumonias MESHD were divided into non-COVID-19 (133 cases) and COVID-19 (121 cases). The non-COVID-19 pneumonias HP pneumonias MESHD included 3 types: cytomegalovirus (CMV) (31 cases), influenza A virus (82 cases), and influenza B virus (20 cases). The differences in the basic clinical characteristics, lesion distribution, location and imaging signs among the four viral pneumonias HP pneumonias MESHD were analyzed and compared.Results: Fever HP Fever MESHD and cough HP cough MESHD were the most common clinical symptoms of the four viral pneumonias HP pneumonias MESHD. Compared with the COVID-19 patients, the non-COVID-19 patients had higher proportions of fatigue HP fatigue MESHD, sore throat, expectorant and chest tightness HP chest tightness MESHD (all p<0.000). In addition, in the CMV pneumonia MESHD pneumonia HP patients, the proportion of patients with combined acquired immunodeficiency HP immunodeficiency MESHD syndrome ( AIDS MESHD) and leukopenia HP leukopenia MESHD were high (all p<0.000). Comparisons of the imaging findings of the four viral pneumonias HP pneumonias MESHD showed that pulmonary lesions of COVID-19 were more likely to occur in the peripheral and lower lobes of both lungs, while those of CMV pneumonia MESHD pneumonia HP were diffusely distributed. Compared with the non-COVID-19 pneumonias HP pneumonias MESHD, COVID-19 pneumonia HP pneumonia MESHD was more likely to present as ground-glass opacity (GGO), intralobular interstitial thickening HP, vascular thickening and halo sign (all p<0.05). In addition, in the early stage of COVID-19, extensive consolidation, fibrous stripes, subpleural lines, crazy-paving pattern, tree-in-bud HP, mediastinal lymphadenectasis, pleural thickening HP pleural thickening MESHD and pleural effusion HP pleural effusion MESHD were rare (all p<0.05).Conclusion: The HRCT findings of COVID-19 pneumonia HP pneumonia MESHD and other viral pneumonias MESHD pneumonias HP overlapped significantly, but many important differential imaging features could still be observed.

    Chest CT imaging characteristics of COVID-19 pneumonia HP pneumonia MESHD in preschool children TRANS: a retrospective study

    Authors: Yang Li; Jianghui Cao; Xiaolong Zhang; Guangzhi Liu; Xiaxia Wu; Baolin Wu

    doi:10.21203/ Date: 2020-04-07 Source: ResearchSquare

    Background: Recently, the World Health Organization has declared the coronavirus disease MESHD 2019 (COVID-19) outbreak a public health emergency of international concern. So far, however, limited data are available for children TRANS. Therefore, we aimed to investigate the clinical and chest CT imaging characteristics of COVID-19 in preschool children TRANS.Methods: From January 26, 2020 to February 20, 2020, the clinical and initial chest CT imaging data of eight preschool children TRANS with laboratory-confirmed COVID-19 from two hospitals were retrospectively collected. The chest CT imaging characteristics, including the distribution, shape, and density of lesions, and the pleural effusion HP pleural effusion MESHD, pleural changes, and enlarged lymph nodes were evaluated. Results: Two cases (25%) were classified as mild type, and they showed no obvious abnormal CT findings or minimal pleural thickening HP pleural thickening MESHD on the right side. Five cases (62.5%) were classified as moderate type. Among these patients, one case showed consolidation located in the subpleural region of the right upper lobe, with thickening in the adjacent pleura; one case showed multiple consolidation and ground-glass opacities with blurry margins; one case displayed bronchial pneumonia HP pneumonia MESHD-like changes in the left upper lobe; and two cases displayed asthmatic bronchitis HP bronchitis MESHD-like changes. One case (12.5%) was classified as critical type and showed bronchial pneumonia MESHD pneumonia HP-like changes in the bilateral lungs, presenting blurred and messy bilateral lung markings MESHD and multiple patchy shadows scattered along the lung markings with blurry margins.Conclusions: The chest CT findings of COVID-19 in preschool children TRANS are atypical and various. Accurate diagnosis requires a comprehensive evaluation of epidemiological, clinical, laboratory and CT imaging data. 

    CT findings of patients infected with SARS-CoV-2

    Authors: Xiaoyang Wang; Chenbin Liu; Liang Hong; Cuiyun Yuan; Jiguang Ding; Qing Jia; Gangqiang Sun; Wenxian Peng; Qingfeng Sun

    doi:10.21203/ Date: 2020-03-02 Source: ResearchSquare

    Objective: We aimed to describe the chest CT findings in sixty-seven patients infected by Severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2). Method and material: We retrospectively reviewed 67 patients hospitalized in Ruian People's Hospital. All the patients received the positive diagnosis of SARS-CoV-2 infection MESHD. The CT and clinical data were collected between January 23 rd , 2020 and February 10 th , 2020. The CT images were analyzed by the senior radiologists. Conclusion: There are 54 patients with positive CT findings and 13 patients with negative CT findings. The typical CT findings in hospitalized patients with SARS-CoV-2 infection MESHD were ground glass opacities (42/54), lesions located in the peripheral area (50/54), multiple lesions (46/54), and lesions located in the lower lobes (42/54). There were less typical CT findings, including air bronchogram (18/54), pleural thickening HP pleural thickening MESHD or pleural effusion HP pleural effusion MESHD (14/54), consolidation (12/54), lesions in the upper lobes (12/54), interlobular septal thickening (11/54), reversed halo sign (9/54), single lesion (8/54), air cavities (4/54), bronchial wall thickening (3/54), and intrathoracic lymph node enlargement (2/54).

    A preliminary study on the ultrasonic manifestations of peripulmonary lesions of non-critical novel coronavirus pneumonia MESHD pneumonia HP (COVID-19) 

    Authors: Yi Huang; Sihan Wang; Yue Liu; Yaohui Zhang; Chuyun Zheng; Yu Zheng; Chaoyang Zhang; Weili Min; Ming Yu; Mingjun Hu

    doi:10.21203/rs.2.24369/v1 Date: 2020-02-21 Source: ResearchSquare

    Background: Ultrasound is used to observe the imaging manifestations of COVID-19 in order to provide reference for real-time bedside evaluation.Purpose: To explore the ultrasonic manifestations of peripulmonary lesions of non-critical COVID-19, so as to provide reference for clinical diagnosis and efficacy evaluation.Materials and Methods: The clinical and ultrasonic data of 20 patients with clinically diagnosed non-critical COVID-19 treated in Xi'an Chest Hospital during January and February 2020 were retrospectively analyzed. Conventional two-dimensional ultrasound and color Doppler ultrasound were used to observe the characteristics of lesions. Results: All 20 patients (40 lungs and 240 lung areas) had a history of travel TRANS, residence or close contact TRANS in/with Wuhan, and 5 of them caught COVID-19 after family gatherings. Lesions tended to occur in both lungs. Lesions in the lung areas: 14 in L1+R1 area (14/40), 17 in L2+R2 area (17/40), 17 in L3+R3 area (17/40), 17 in L4+R4 area (17/40), 20 in L5+R5 area (20/40), and 28 in L6+R6 area (28/40). L esion MESHDtypes: rough and discontinuous p leural MESHDline (36/240), subpleural consolidation (53/240), air bronchogram sign or air bronchiologram sign in subpleural peripleural consolidation (37/240), visible B lines (91/240), localized pleural thickening HP leural MESHDthickening (19/240), localized pleural effusion HP leural effusion MESHD(24/240), poor blood SERO flow in the consolidation detected by color Doppler ultrasound (50/53).Conclusion: The non-critical COVID-19 has characteristic ultrasonic manifestations, which are visible in the posterior and inferior areas of the lung. The lesions are mainly characterized by a large number of B lines, s ubpleural pulmonary consolidation MESHDand poor blood SERO flow. Lung ultrasound can provide reference for the clinical diagnosis and efficacy evaluation. Chinese Clinical Trial Registry: ChiCTR2000030032Approval for Scientific Research Project: No. 2020-S0001

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MeSH Disease
Human Phenotype

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