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Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Lung ultrasound findings in pediatric patients with COVID-19.

    Authors: Carmina Guitart; Ricardo Suárez; Mònica Girona; Sara Bobillo-Pérez; Lluïsa Hernández; Mònica Balaguer; Francisco José Cambra; Iolanda Jordan

    doi:10.21203/rs.3.rs-58977/v1 Date: 2020-08-13 Source: ResearchSquare

    During the pandemic caused by the novel coronavirus (COVID-19), lung ultrasound has been used to diagnose and monitor respiratory condition. The aim of the study was to describe lung ultrasound findings in children TRANS with a COVID-19 infection MESHD. Patients younger than 18 years old and positive for COVID-19, admitted to pediatric tertiary referral hospital were included. They were divided into two groups depending on the presence of respiratory symptoms. Lung ultrasound results were categorized into three degrees of aeration loss: normal, moderate, and severe; and into three patterns: viral or bacterial pneumonia MESHD pneumonia HP, and atelectasis HP.Sixteen patients were recruited. The median age TRANS was 11 years old (IQR 2.8-12). Four children TRANS (25%) required admission to the intensive care unit. Six patients (37.5%) presented with respiratory symptoms. All of them (100%) showed moderate-to-severe aeration loss on lung ultrasound. A viral pneumonia HP pneumonia MESHD pattern was observed in four cases (66.6%). Ten patients (62.5%) presented with non-respiratory symptoms, lung ultrasound showed moderate-to-severe aeration loss in nine (90%). Three (30%) were diagnosed of multisystem inflammatory syndrome MESHD and lung MESHD ultrasounds showed severe aeration loss and bilateral pleural effusion MESHD pleural effusion HP.Conclusions: Children TRANS with COVID-19 and respiratory symptoms showed a viral pneumonia HP pneumonia MESHD pattern with moderate-to-severe aeration loss upon the lung ultrasound assessment.

    CT as a Tool to Depict Pulmonary Fibrosis MESHD Pulmonary Fibrosis HP in Patients With COVID-19: a Radiopathological Correlation 

    Authors: Anna Alguersuari; Miguel Angel Carrasco; Gemma Munné; Maria Eulalia Oliva; Cristina Simon; Maria Dolores Bosque; Melcior Martínez; Natalia Lugo; Xavier Herranz; Mariana Rovira

    doi:10.21203/rs.3.rs-44197/v1 Date: 2020-07-16 Source: ResearchSquare

    OBJECTIVESCT findings of COVID-19 i nfected MESHDpatients has been well described, but it it’s roll in depicting signs of f ibrosis MESHDin c ritically ill MESHDpatients remains unclear. To our knowledge, there are no radiopathological correlations of the pulmonary pathology. Exudative and proliferative diffuse a lveolar damage MESHD(DAD) are the most commonly reported injury. Few studies describe f ibrosis, MESHD the last phase of DAD. Our study correlates post-mortem chest US and CT findings of COVID-19 i nfected MESHDpatients with the histopathology from biopsies taken of the lung. It focuses on the role of CT to depict f ibrosis. MESHD METHODSThis is a prospective observational study of six consecutive deceased patients infected with COVID-19. Post-mortem chest CTs and US were performed within 24 hours of d eath. MESHD CT and US were used to obtain biopsies of different radiological patterns. Pre-mortem CT examinations were also retrospectively evaluated. RESULTSOn CT, all patients presented with extensive areas of consolidation and ground-glass opacities affecting most segments of the lung. Pleural effusion HP leural effusion MESHDwas present in all cases. Four of the patients showed signs of f ibrosis. MESHD On US, subpleural consolidation, pleural thickening HP leural MESHDthickening, and B-pattern were present.All patients showed different stages of DAD, mostly proliferative DAD. Four patients presented with f ibrotic DAD, MESHD all of which had been admitted for over three weeks and correlated with the CT findings of f ibrosis. MESHD CONCLUSIONIn our study, signs of f ibrosis MESHDon CT show a histopathological correlation. CT may be useful to identify the group of C OVID-infected MESHDpatients that develop f ibrosis MESHDas a marker of poor prognosis, in the late stage of the disease.

    Pulmonary Thromboembolic Disease MESHD in Patients with COVID-19 Undergoing Computed Tomography Pulmonary Angiography (CTPA): Incidence and Relationship with Pulmonary Parenchymal Abnormalities MESHD

    Authors: Cheng Fang; Giorgio Garzillo; Bhavna Batohi; James T Teo; Marko Berovic; Paul Sidhu; Hasti Robbie

    doi:10.1101/2020.06.01.20118505 Date: 2020-06-02 Source: medRxiv

    Purpose This study aims to report the incidence, severity and extent of pulmonary thromboembolic disease MESHD ( PTD MESHD) in patients with confirmed COVID-19 who have undergone CT pulmonary angiography (CTPA) in a tertiary centre. Materials and Methods This is a retrospective analysis of all patients undergoing CTPA between 23rd March 2020 and 19th April 2020 in a tertiary centre. The presence of PTD MESHD, location and involved pulmonary lobes MESHD were documented. The pattern and extent of pulmonary parenchymal abnormalities MESHD including the presence of fibrosis MESHD, lymph node enlargement MESHD and pleural effusion HP pleural effusion MESHD were evaluated by two experienced observers independently and consensus was achieved for the most disparate results. Inter-observer agreement was assessed using Kappa statistics. Student t-test, Chi square and Mann-Whitney U tests were used to compare imaging features between PTD MESHD and non- PTD MESHD sub-groups. Results During the study period, 2157 patients were confirmed with COVID-19, 297/2157 (13.8%) had CT imaging, 100/2157 (4.6%) were CTPA studies, 93 studies were analysed, excluding sub-optimal studies. Overall incidence of PTD MESHD was 41/93 (44%) with a third of patients showing segmental and subsegmental PTD MESHD (n=28/93, 30%,). D-dimer was elevated in 90/93 (96.8%) of cases. High Wells score did not differentiate between PE and non-PE groups (p=0.801). The inter-observer agreement was fair (Kappa=0.659) for parenchymal pattern and excellent (Kappa = 0.816) for severity. Lymph node enlargement was found in 34/93 of cases (36.6%) with 29/34 (85.3%) showing no additional source of infection MESHD. Fibrosis MESHD was seen in 16/93 (17.2%) of cases, mainly demonstrating fibrotic organising pneumonia HP pneumonia MESHD. Conclusion There is a high incidence of PTD MESHD in COVID -19 patients undergoing CTPA, complicated by lack of a valid risk stratification tool. Our data indicates a much higher suspicion of PTD MESHD is needed in severe COVID-19 patients. The concomitant presence of fibrotic features on CT indicates the need for follow-up for evaluation of chronic pulmonary complications MESHD.

    Comparison of Hospitalized Patients with Severe Pneumonia MESHD Pneumonia HP Caused by COVID-19 and Highly Pathogenic Avian Influenza (H7N9): A Retrospective Study from A Designated Hospital

    Authors: Binbin Gu; Lin Yao; XinYun Zhu; Pei-jun Tang; Cheng Chen

    doi:10.21203/rs.3.rs-28119/v1 Date: 2020-05-08 Source: ResearchSquare

    Background Considerable attention has been focused on clinical features of Coronavirus Disease MESHD 2019 (COVID-19), it is also important for clinicians to differentiate it from influenza virus infections MESHD.Methods The clinical data of 23 cases of H7N9 and 23 cases of COVID-19 with severe pneumonia HP pneumonia MESHD were collected. The comparisons were performed with the t test, Mann-Whitney U test, Fisher exact test or the chi-squared test, and multivariable logistic regression analysis.Results All of the cases were under the circumstance of sufficient medical staff and medical supplies. The rate of coexisting disease was lower in the severe COVID-19 group than in the severe H7N9 group (p < 0.05). Radiologically, severe COVID-19 patients had less consolidation and pleural effusion HP pleural effusion MESHD, but more crazy-paving pattern than severe H7N9 patients (p < 0.05). Clinically, compared to severe H7N9, severe COVID-19 patients were more inclined to surfer to relative better disease severity score, less secondary bacterial infection MESHD, a shorter time to beginning absorption on CT, but a longer duration of viral shedding from the admission (p < 0.05). Although more severe H7N9 patients needed non-invasive respiratory support, these two groups ultimately yielded comparable mortality. Based on multiple logistic regression analysis, severe COVID-19 infection MESHD was associated with a lower risk of the presence of severe ARDS (OR 0.964, 95% [CI] 0.931–0.998, p = 0.040), but exhibited longer duration of viral shedding (OR 0.734, 95% [CI] 0.550–0.980, p = 0.036) than severe H7N9 infection MESHD.Conclusion Although the conditions of severe H7N9 patients seemed to be more critical than those of severe COVID-19 patients, the relatively lower mortality of these two severe cases is to be expected in context of sufficient medical supplies.

    The first 2019-nCoV infection case report from Iran

    Authors: Maryam Mansoori; Somayeh Vafaei; Zahra Madjd; Masoume Mesgarian

    doi:10.21203/rs.3.rs-26452/v1 Date: 2020-05-01 Source: ResearchSquare

    Background: The total mortality rate of COVID-19 is estimated almost at 2 % based on a wide range of publications. To avoid negative global impact of this new emergency, the entailment of control measures for prevention is highly recommended. Unfortunately, Iran has been the manifestation of attention as one of the countries is struggling with this pandemic. Here we intend to report a unique case of 2019-nCoV infected patient with underlying diseases MESHD and one of the rare pulmonary manifestations of 2019-nCoV infection MESHD ( pleural effusion HP pleural effusion MESHD) who has recovered and discharged. Case presentation: The current case report from Iran showed a positive COVID-19 case accompanied by pleural effusion HP pleural effusion MESHD and severe pneumonia HP pneumonia MESHD and even underlying diseases. She received twelve days of treatment and recovered with good oxygen saturation and without associated factors including fever HP fever MESHD and cough HP cough MESHD. In this report, presentations, diagnoses and management of novel 2019 coronavirus patient has been described in details. Conclusions: The pleural effusion HP pleural effusion MESHD in 2019-nCoV is not a dominant feature and can be considered as one of the diagnostic features in the disease. Even with underlying diseases, 2019-nCoV symptoms are not supposed to be severed. 

    Coronavirus Disease MESHD 2019 (COVID-19) in Italy: features on Chest Computed Tomography using a structured report system

    Authors: Grassi Roberto; Fusco Roberta; Belfiore Maria Paola; Montanelli Alessandro; Patelli Gianluigi; Urraro Fabrizio; Petrillo Antonella; Granata Vincenza; Sacco Palmino; Mazzei Maria Antonietta; Feragalli Beatrice; Reginelli Alfonso; Cappabianca Salvatore

    doi:10.21203/rs.3.rs-24312/v1 Date: 2020-04-21 Source: ResearchSquare

    OBJECTIVE. To assess the use of a structured report system in the Chest Computed Tomography (CT) reporting of patients with suspicious viral pneumonia HP pneumonia MESHD by COVID-19 and the evaluation of the main CT patterns.MATERIALS AND METHODS. This study included 134 patients (43 women and 91 men; 68.8 years of mean age TRANS, range 29-93 years) with suspicious COVID-19 viral infection MESHD evaluated by reverse transcription real-time fluorescence polymerase chain reaction (RT-PCR) test. All patients underwent CT examinations at the time of admission. CT images were reviewed by two radiologists who identified COVID-19 CT patterns using a structured reports.RESULTS. Temporal difference mean value between RT-PCRs and CT scan was 0.18 days ±2.0 days. CT findings were positive for viral pneumonia MESHD pneumonia HP in 94.0% patients while COVID-19 was diagnosed at RT-PCR in 77.6% patients. Mean value of time for radiologist to complete the structured report was 8.5 min±2.4 min. The disease on chest CT predominantly affected multiple lobes and the main CT feature was GGOs with or without consolidation (96.8%). GGOs was predominantly bilateral (89.3%), peripheral (80.3%), multifocal/patching (70.5%). Consolidation disease was predominantly bilateral (83.9%) with prevalent peripheral (87.1%) and segmental (47.3%) distribution. Additional CT signs were the crazy-paving pattern in 75.4% of patients, the septal thickening in 37.3% of patients, the air bronchogram sign in 39.7% and the “reversed halo” sign in 23.8%. Less frequent characteristics at CT regard discrete pulmonary nodules, increased trunk diameter of the pulmonary artery, pleural effusion HP pleural effusion MESHD and pericardium effusion (7.9%, 6.3%, 14.3% and 16.7%, respectively). Barotrauma MESHD sign was absent in all the patients. High percentage (54.8%) of the patients had mediastinal lymphadenopathy HP mediastinal lymphadenopathy MESHD.CONCLUSION. Using a Chest CT structured report, with a standardized language, we identified that the cardinal hallmarks of COVID-19 infection MESHD were bilateral, peripheral and multifocal/patching ground-glass opacities and bilateral consolidations with peripheral and segmental distribution. 

    A Mini Review on Current Clinical and Research Findings for Children TRANS Suffering from COVID-19

    Authors: Xiao Li; Kun Qian; Ling-ling Xie; Xiu-juan Li; Min Cheng; Li Jiang; Bjoern W. Schuller

    doi:10.1101/2020.03.30.20044545 Date: 2020-04-04 Source: medRxiv

    Background: As the novel coronavirus triggering COVID-19 has broken out in Wuhan, China and spread rapidly worldwide, it threatens the lives of thousands of people and poses a global threat on the economies of the entire world. However, infection MESHD with COVID-19 is currently rare in children TRANS. Objective To discuss the latest findings and research focus on the basis of characteristics of children TRANS confirmed with COVID-19, and provide an insight into the future treatment and research direction. Methods: We searched the terms "COVID-19 OR coronavirus OR SARS-CoV-2" MESHD AND "Pediatric OR children TRANS" on PubMed, Embase, Cochrane library, NIH, CDC, and CNKI. The authors also reviewed the guidelines published on Chinese CDC and Chinese NHC. Results: We included 25 published literature references related to the epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. Conclusion: The numbers of children TRANS with COVID-19 pneumonia HP pneumonia MESHD infection are small, and most of them come from family aggregation. Symptoms are mainly mild or even asymptomatic TRANS, which allow children TRANS to be a risk factor for transmission TRANS. Thus, strict epidemiological history screening is needed for early diagnosis and segregation. This holds especially for infants, who are more susceptible to infection MESHD than other age groups TRANS in pediatric age TRANS, but have most likely subtle and unspecific symptoms. They need to be paid more attention to. CT examination is a necessity for screening the suspected cases, because most of the pediatric patients are mild cases, and plain chest X-ray do not usually show the lesions or the detailed features. Therefore, early chest CT examination combined with pathogenic detection is a recommended clinical diagnosis scheme in children TRANS. The risk factors which may suggest severe or critical progress for children TRANS are: Fast respiratory rate and/or; lethargy HP and drowsiness HP mental state and/or; lactate progressively increasing and/or; imaging showed bilateral or multi lobed infiltration, pleural effusion HP pleural effusion MESHD or rapidly expending of lesions in a short period of time and/or; less than 3 months old or those who underly diseases. For those critical pediatric patients with positive SARS-CoV-2 diagnosis, polypnea may be the most common symptom. For treatment, the elevated PCT seen in children TRANS in contrast to adults TRANS suggests that the underlying coinfection/ secondary infection MESHD may be more common in pediatric patients and appropriate antibacterial treatment should be considered. Once cytokine storm is found in these patients, anti-autoimmune or blood SERO-purifying therapy should be given in time. Furthermore, effective isolation measures and appropriate psychological comfort need to be provided timely.

    Clinical characterization and chest CT findings in laboratory-confirmed COVID-19: a systematic review and meta-analysis

    Authors: Golnaz Vaseghi; Marjan Mansourian; Raheleh Karimi; Kiyan Heshmat-Ghahdarijani; Sadegh Baradaran Mahdavi; Amirhossein Pezeshki; Behrooz Ataei; Alireza Zandifar; Omid Shafaat; Shaghayegh Haghjoo Javanmard

    doi:10.1101/2020.03.05.20031518 Date: 2020-03-08 Source: medRxiv

    Background: Imagery techniques have been used as essential parts of diagnostic workup for patients suspected for 2019-nCoV infection MESHD, Multiple studies have reported the features of chest computed tomography (CT) scans among a number of 2019-nCoV patients. Method: Study Identification was carried out in databases (PubMed, Embase and Cochrane Library) to identify published studies examining the diagnosis, the 2019 novel coronavirus (2019-nCoV). Heterogeneity among reported prevalence SERO was assessed by computing p-values of Cochrane Q-test and I2-statics. The pooled prevalence SERO of treatment failure was carried out with a fixed effects meta-analysis model, generating the pooled 95% confidence interval. A random-effect model was used to pool the results since this model could incorporate the heterogeneity of the studies and therefore proved a more generalized result. Results: According to the combined results of meta-analysis, the total 55% of corona patients were males TRANS. The mean age TRANS of the patients was 41.31 (34.14, 48.47). Two prevalent clinical symptoms between patients were fever HP fever MESHD, cough HP cough MESHD with prevalence SERO of 85%, and 62%, respectively. Either Ground Glass Opacity GGO or consolidation was seen in 86% but 14% had NO GGO or consolidation. The other rare CT symptoms were pericardial effusion HP, and pleural effusion HP pleural effusion MESHD with 4, 5, 7% prevalence SERO, respectively. The most prevalent event was Either GGO or consolidation in 85% of patients. Conclusion: The most CT-scan abnormality is Either Ground Glass Opacity GGO or consolidation however in few patients none of them might be observed, so trusting in just CT findings will lead to miss some patients.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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