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Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Clinical Features of Pregnant Women and Neonates with COVID-19 in Wuhan: a paired comparison study

    Authors: Qin Xie; Quan Gan; Jing Hu; Dong Zhou; Shuhan Cai; Lianjiu Su; Yunxiang Li; Yiming Li; Zhiyong Peng

    doi:10.21203/rs.3.rs-31339/v1 Date: 2020-05-26 Source: ResearchSquare

    Background Our study aimed to find symptoms unique in pregnancy and to help the early diagnosis in pregnant women and to evaluate the impact of COVID-19 in postpartum women and their newborns.Methods Clinical data were reviewed and collected for 11 pregnant women with laboratory-confirmed COVID-19 who were consecutively admitted to Zhongnan Hospital of Wuhan University and Women and Children’s Hospital of Hubei Province, from Jan 26 to Feb 26, 2020.Results All the confirmed women didn’t have any exposure history and their early symptoms were mildly elevated temperate and fatigue HP fatigue MESHD. The chest CT scans of confirmed women can be atypical manifestations, such as bilateral pleural effusions MESHD pleural effusions HP and slightly increased densities. Eight of eleven confirmed women did not feel anything unusual until abnormalities were found on chest CT scans on admission screening test. All three groups had elevated white blood SERO cell count, neutrophil count and lactate dehydrogenase, and reduced total protein.The infection did not increase the risk for premature delivery, premature rupture of membrane HP, or comorbidities in pregnancy.Conclusions Pregnant women were often asymptomatic TRANS and accidentally detected abnormalities MESHD on chest CT scan on admission which emphasize the importance of CT scan in prevalent areas of the COVID-19. Even after the laboratory confirmation, the manifestation of the CT scan could be atypical, which alerted the necessity of protection for healthcare workers. The COVID-19 did not increase the risk of complications in pregnant women and their neonates.Trial registration: This case series was approved by the institutional ethics board of Zhongnan Hospital of Wuhan University (No. 2020020) and Women and Children’s Hospital of Hubei Province(NO. LW035).

    18F-FDG PET/CT uptake in COVID-19: case report of a patient with lung metastases MESHD after treatment of nasal cavity malignancy MESHD

    Authors: Hongyan Feng; Lihong Bu

    doi:10.21203/rs.3.rs-23861/v1 Date: 2020-04-20 Source: ResearchSquare

    Background: In high COVID-19 prevalence SERO region, COVID-19 disease may be incidental found in non-specific symptoms or asymptomatic TRANS patient with history of tumor MESHD who underwent 18F-FDG-PET/CT for standard oncologic indications.Case presentation: A 51-year-old woman with a 4-year history of adenoid cystic carcinoma of nasal cavity MESHD carcinoma HP of nasal cavity underwent 18F-FDG PET/CT for restaging during COVID-19 outbreak in Wuhan. Pneumonia HP Pneumonia MESHD lesions were characterized by 18F-FDG uptake ground-glass opacities (GGOs) and multifocal high 18F-FDG-avid patchy consolidation, and without lymph node involvement and pleural effusion HP pleural effusion MESHD. Furthermore, multiple 18F-FDG-positive lung and lumbar metastases MESHD were observed. Finally, a diagnosis of COVID-19 was made based on a positive real-time fluorescent polymerase chain reaction (RT-PCR) test of SARS-CoV-2 nucleic acid. Conclusion: The non-specific symptoms or asymptomatic TRANS cancer MESHD patients presenting 18F-FDG-positive GGOs and patchy consolidation lesions in lung may favor COVID-19, who should be quickly SARS-CoV-2 nucleic acid tested and monitored.

    A Mini Review on Current Clinical and Research Findings for Children TRANS Suffering from COVID-19

    Authors: Xiao Li; Kun Qian; Ling-ling Xie; Xiu-juan Li; Min Cheng; Li Jiang; Bjoern W. Schuller

    doi:10.1101/2020.03.30.20044545 Date: 2020-04-04 Source: medRxiv

    Background: As the novel coronavirus triggering COVID-19 has broken out in Wuhan, China and spread rapidly worldwide, it threatens the lives of thousands of people and poses a global threat on the economies of the entire world. However, infection MESHD with COVID-19 is currently rare in children TRANS. Objective To discuss the latest findings and research focus on the basis of characteristics of children TRANS confirmed with COVID-19, and provide an insight into the future treatment and research direction. Methods: We searched the terms "COVID-19 OR coronavirus OR SARS-CoV-2" MESHD AND "Pediatric OR children TRANS" on PubMed, Embase, Cochrane library, NIH, CDC, and CNKI. The authors also reviewed the guidelines published on Chinese CDC and Chinese NHC. Results: We included 25 published literature references related to the epidemiology, clinical manifestation, accessary examination, treatment, and prognosis of pediatric patients with COVID-19. Conclusion: The numbers of children TRANS with COVID-19 pneumonia HP pneumonia MESHD infection are small, and most of them come from family aggregation. Symptoms are mainly mild or even asymptomatic TRANS, which allow children TRANS to be a risk factor for transmission TRANS. Thus, strict epidemiological history screening is needed for early diagnosis and segregation. This holds especially for infants, who are more susceptible to infection MESHD than other age groups TRANS in pediatric age TRANS, but have most likely subtle and unspecific symptoms. They need to be paid more attention to. CT examination is a necessity for screening the suspected cases, because most of the pediatric patients are mild cases, and plain chest X-ray do not usually show the lesions or the detailed features. Therefore, early chest CT examination combined with pathogenic detection is a recommended clinical diagnosis scheme in children TRANS. The risk factors which may suggest severe or critical progress for children TRANS are: Fast respiratory rate and/or; lethargy HP and drowsiness HP mental state and/or; lactate progressively increasing and/or; imaging showed bilateral or multi lobed infiltration, pleural effusion HP pleural effusion MESHD or rapidly expending of lesions in a short period of time and/or; less than 3 months old or those who underly diseases. For those critical pediatric patients with positive SARS-CoV-2 diagnosis, polypnea may be the most common symptom. For treatment, the elevated PCT seen in children TRANS in contrast to adults TRANS suggests that the underlying coinfection/ secondary infection MESHD may be more common in pediatric patients and appropriate antibacterial treatment should be considered. Once cytokine storm is found in these patients, anti-autoimmune or blood SERO-purifying therapy should be given in time. Furthermore, effective isolation measures and appropriate psychological comfort need to be provided timely.

    In-flight Transmission TRANS Cluster of COVID-19: A Retrospective Case Series

    Authors: Naibin Yang; Yuefei Shen; Chunwei Shi; Ada Hoi Yan Ma; Xie Zhang; Xiaomin Jian; Liping Wang; Jiejun Shi; Chunyang Wu; Guoxiang Li; Yuan Fu; Keyin Wang; Mingqin Lu; Guoqing Qian

    doi:10.1101/2020.03.28.20040097 Date: 2020-03-30 Source: medRxiv

    Objectives: No data were available about in-flight transmission TRANS of SARS-CoV-2. Here, we report an in-flight transmission TRANS cluster of COVID-19 and describe the clinical characteristics of these patients. Methods: After a flight, laboratory-confirmed COVID-19 was reported in 12 patients. Ten patients were admitted to the designated hospital. Data were collected from 25th January to 28th February 2020. Clinical information was retrospectively collected. Results: All patients are passengers without flight attendants. The median age TRANS was 33 years, and 70% were females TRANS. None was admitted to intensive care unit, and no patients succumbed through 28th February. The median incubation period TRANS was 3.0 days and from illness onset to hospital admission was 2 days. The most common symptom was fever HP fever MESHD. Two patients were asymptomatic TRANS and negative for chest CT scan throughout the disease course. On admission, initial RT-PCR were positive in 9 patients, however initial chest CT were positive in only half patients. The median lung total severity score of chest CT was 6. Notably, Crazy-Paving pattern, pleural effusion HP pleural effusion MESHD, and ground-glass nodules were also seen. Conclusion: It is potential for COVID-19 transmission TRANS by airplane, but the symptoms are mild. Passengers and attendants must be protected during the flight.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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