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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    Hyponatremia HP Hyponatremia MESHD is Associated with Poor Outcome in COVID-19

    Authors: Hugo DE CARVALHO; Thibault LETELLIER; Matilde KARAKACHOFF; Geoffrey DESVAUX; Hélène CAILLON; Emmanuelle PAPUCHON; Maxime BENTOUMI-LOAEC; Nesrine BENAOUICHA; Emmanuel CANET; Guillaume CHAPELET; Paul LE TURNIER; Emmanuel MONTASSIER; Armine ROUHANI; Nicolas GOFFINET; Lucile FIGUERES

    doi:10.21203/rs.3.rs-62360/v1 Date: 2020-08-19 Source: ResearchSquare

    Background Hyponatremia HP Hyponatremia MESHD has been described in severe acute respiratory syndrome MESHD. Our objective was to describe the impact of hyponatremia HP hyponatremia MESHD on COVID-19 patients’ outcome (intensive care unit [ICU] admission, mechanic ventilation or death MESHD).Methods According to natremia at admission, two groups were retrospectively screened: hyponatremic (< 135 mM, n = 101) or normonatremic ( natremia ≥ 135 mM MESHD, n = 222) patients. Pearson’s chi-2 (qualitative variables) and Student tests (quantitative variables) were used to compare the two groups. A multiple logistic regression model was used to assess the association of outcome and patients’ data.Results Hyponatremia HP Hyponatremia MESHD was generally mild. There were more male TRANS patients in the hyponatremic group (p = 0.005). Pulmonary lesions on the first thoracic CT-scanner performed during the hospitalization were significantly more extended in the hyponatremic group (p = 0.03). ICU admission, mechanic ventilation or death MESHD were significantly higher in hyponatremic compared to normonatremic patients (34 versus 14%; p < 0.001; 16% versus 5%; p = 0.002; 19 versus 9%, p = 0.021, respectively). Hyponatremia HP Hyponatremia MESHD was an independent predictor of poor outcome (adjusted Odds-ratio: 2.49 [1.18–5.33, p = 0.017]).Conclusions Our study showed an independent relationship between hyponatremia HP hyponatremia MESHD at admission and transfer to ICU, use of mechanic ventilation or death MESHD in COVID-19. Hyponatremia HP Hyponatremia MESHD may reflect the potential severity of underlying pulmonary lesions MESHD. Our results support the use of natremia as a simple bedside screening tool for early identification of SARS-CoV-2 infected MESHD patients at high risk of poor outcome.

    The involvement of Central Nervous System and sequence variability of Severe Adult Respiratory Syndrome MESHD Adult TRANS Respiratory Syndrome – Coronavirus-2 revealed in autopsy tissue samples: a case report.

    Authors: Lis Høy Marbjerg; Christina Jacobsen; Jannik Fonager; Claus Bøgelund; Morten Rasmussen; Anders Fomsgaard; Jytte Banner; Veronika Vorobieva Solholm Jensen

    doi:10.21203/rs.3.rs-61471/v1 Date: 2020-08-18 Source: ResearchSquare

    Background: The case presented here illustrates that interdisciplinary teamwork can be essential for the understanding of the COVID-19 disease presentation and enlightening of the pathophysiology. Case presentation: A 60-years-old overweight HP woman without any comorbidities was found dead in her apartment after 14 days of home isolation due to suspicion on the Coronavirus disease MESHD 2019 (COVID-19). She had reported symptoms of tachycardia HP tachycardia MESHD, fever HP fever MESHD, and increasing respiratory difficulty one day before her death MESHD. Due to the Danish legal act on sudden deaths a forensic autopsy was performed including a thorough examination and biosampling. The results of the forensic autopsy displayed sever densified, almost airless, firm lungs, and an unspecific reactive minimal focal perivascular inflammation MESHD consisting of macrophages of the brain tissue. The final diagnosis, COVID-19 with involvement of the central nervous system was established by use of the RT-RNA analysis on cerebrospinal fluid, as well as by serologic detection of the specific antibodies for SARS-CoV-2 SERO in cerebrospinal fluid and serum SERO. The genetic analysis displayed a 2 % variation between SARS-CoV-2 isolates recovered from the tracheal sample, cerebrospinal fluid, and tissues from both lungs.Conclusion: The combination of all available results revealed that the cause of death MESHD was COVID-19 with severe pulmonary disease MESHD and neuroinvasion, as well as renal affection resulting in hyponatremia HP hyponatremia MESHD. To our knowledge, it was not shown previously that neuroinvasion could be confirmed by the detection of specific antibodies for SARS-CoV-2 SERO and SARS-CoV-2 specific RNA in cerebrospinal fluid. This case supports hypotheses that SARS-CoV-2 may cause central nervous system infection MESHD. The genetic distinction between SARS-CoV-2 isolates was done by whole-genome sequencing, where the isolate recovered from the cerebrospinal fluid was the most different. 

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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