Corpus overview


Overview

MeSH Disease

Fatigue (151)

Fever (142)

Coronavirus Infections (81)

Cough (77)

Dyspnea (65)


Human Phenotype

Cough (172)

Fatigue (172)

Fever (158)

Pneumonia (48)

Myalgia (47)


Transmission

Seroprevalence
    displaying 131 - 140 records in total 172
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    COVID-19 clinical characteristics, and sex-specific risk of mortality: Systematic Review and Meta-analysis

    Authors: Mohammad Javad Nasiri; Sara Haddadi; Azin Tahvildari; Yeganeh Farsi; Mahta Arbabi; Saba Hasanzadeh; Parnian Jamshidi; Mukunthan Murthi; Mehdi Mirsaeidi

    doi:10.1101/2020.03.24.20042903 Date: 2020-03-26 Source: medRxiv

    Objectives: The rapidly evolving coronavirus disease MESHD 2019 (COVID-19), was declared a pandemic by the World Health Organization on March 11, 2020. It was first detected in the city of Wuhan in China and has spread globally resulting in substantial health and economic crisis in many countries. Observational studies have partially identified the different aspects of this disease. Up to this date, no comprehensive systematic review for the clinical, laboratory, epidemiologic and mortality findings has been published. We conducted this systematic review and meta-analysis for a better understanding of COVID-19. Methods: We reviewed the scientific literature published from January 1, 2019 to March 3, 2020. Statistical analyses were performed with STATA (version 14, IC; Stata Corporation, College Station, TX, USA). The pooled frequency with 95% confidence intervals (CI) was assessed using random effect model. Publication bias was assessed and p <0.05 was considered a statistically significant publication bias. Results: Out of 1102 studies, 32 satisfied the inclusion criteria. A total of 4789 patients with a mean age TRANS of 49 years were evaluated. Fever HP Fever MESHD (83.0%, CI 77.5 to 87.6), cough HP cough MESHD (65.2%, CI 58.6 to 71.2) and myalgia HP myalgia MESHD/ fatigue HP fatigue MESHD (34.7, CI 26.0 to 44.4) were the most common symptoms. The most prevalent comorbidities were hypertension HP hypertension MESHD (18.5 %, CI 12.7 to 24.4) and Cardiovascular disease MESHD (14.9 %, CI 6.0 to 23.8). Among the laboratory abnormalities, elevated C-Reactive Protein (CRP) (72.0% (CI 54.3 to 84.6) and lymphopenia HP (50.1%, CI 38.0 to 62.4) were the most common findings. Bilateral ground-glass opacities (66.0%, CI 51.1 to 78.0) was the most common CT-Scan presentation. Pooled mortality rate was 6.6%, with males TRANS having significantly higher mortality compared to females TRANS (OR 3.4; 95% CI 1.2 to 9.1, P = 0.01). Conclusion: COVID-19 commonly presented with a progressive course of cough HP and fever HP with more than half of hospitalized patients showing leukopenia HP or a high CRP on their laboratory findings. Mortality associated with COVID19 was higher than that reported in studies in China with Males TRANS having a 3-fold higher risk of mortality in COVID19 compared to females TRANS.

    Comorbid Diabetes Mellitus HP Diabetes Mellitus MESHD was Associated with Poorer Prognosis in Patients with COVID-19: A Retrospective Cohort Study

    Authors: Yan Zhang; Yanhui Cui; Minxue Shen; Jianchu Zhang; Ben Liu; Minhui Dai; Linli Chen; Duoduo Han; Yifei Fan; Yanjun Zeng; Wen Li; Fengyu Lin; Sha Li; Xiang Chen; Pinhua Pan

    doi:10.1101/2020.03.24.20042358 Date: 2020-03-26 Source: medRxiv

    Background The 2019 novel coronavirus disease MESHD (COVID-19) emerged in Wuhan, Hubei province, China, and was characterized as pandemic by the World Health Organization. Diabetes mellitus HP Diabetes mellitus MESHD is an established risk factor for poor clinical outcomes, but the association of diabetes MESHD with the prognosis of COVID-19 have not been reported yet. Methods In this cohort study, we retrospectively reviewed 258 consecutive hospitalized COVID-19 patients with or without diabetes MESHD at the West Court of Union Hospital of Huazhong University of Science and Technology in Wuhan, China, recruited from January 29 to February 12, 2020. The cases were confirmed TRANS by real-time PCR and the demographic, clinical, laboratory, radiological, and treatment data were collected and analyzed. Prognosis was defined as hospitalization, discharged survivor and death MESHD, which was followed up until March 12, 2020. Results Of the 258 hospitalized patients (63 with diabetes MESHD) with COVID-19, the median age TRANS was 64 years (range 23-91), and 138 (53.5%) were male TRANS. No significant differences in age TRANS and sex were identified between patients with and without diabetes MESHD. Common symptoms included fever HP fever MESHD (82.2%), dry cough MESHD cough HP (67.1%), polypnea (48.1%), and fatigue HP fatigue MESHD (38%). Patients with diabetes MESHD had significantly higher leucocyte and neutrophil counts, and higher levels of fasting blood SERO glucose, serum SERO creatinine, urea nitrogen and creatine kinase isoenzyme MB at admission compared with those without diabetes MESHD. COVID-19 patients with diabetes MESHD were more likely to develop severe or critical disease condition MESHD with more complications at presentation, and had higher incidence rates of antibiotic therapy, non-invasive and invasive mechanical ventilation, and death MESHD (11.1% vs. 4.1%). Cox proportional hazard model showed that diabetes MESHD (adjusted hazard ratio [aHR]=3.64; 95% confidence interval [CI]: 1.09, 12.21) and fasting blood SERO glucose (aHR=1.19; 95% CI: 1.08, 1.31) were associated with the fatality of COVID-19, adjusting for potential confounders. Conclusions Diabetes mellitus HP Diabetes mellitus MESHD is associated with greater disease severity and a higher risk of mortality in patients with COVID-19. Primary and secondary prevention strategies are needed for COVID-19 patients with diabetes MESHD.

    Moving-average based index to evaluate the epidemic trend of COVID-19 outbreak

    Authors: Yun-ting He; Hao He; Jing Zhai; Xiao-jin Wang; Bing-shun Wang

    doi:10.1101/2020.03.24.20027730 Date: 2020-03-26 Source: medRxiv

    A pneumonia HP pneumonia MESHD outbreak caused by a novel coronavirus (COVID-19) occurred in Wuhan, China at the end of 2019 and then spread rapidly to the whole country. A total of 81,021 laboratory- confirmed cases TRANS, including 3,194 deaths (3.9%) had been reported in China by March 14, 2020, meanwhile, 61,518 laboratory- confirmed cases TRANS and 2,199 deaths were reported outside China. Common symptoms of COVID-19 pneumonia HP pneumonia MESHD included fever HP fever MESHD, fatigue HP fatigue MESHD and dry cough MESHD cough HP. Faced with such a sudden outbreak of new infectious diseases, we have no history to learn from and no evidence to count on. Traditional models often predict inconsistent results. Aiming at estimate the epidemic trend timely after the outbreak, we mainly used 7-day moving average of log-transformed daily new cases (LMA) to establish a new index named "epidemic trend index", which will be used to predict the evolutionary trend of the epidemic situation and support epidemic control decision making processes. We used SARS epidemic data from Hong Kong in 2003 to verify the practicability of the new index, which shows that the index is acceptable. The epidemic trend index was then applied to the COVID-19 epidemic analysis in China. The results show that during the epidemic, the trend direction of different districts of China changed on different date. In the whole country and in Hubei Province alone, the epidemic reached the peak on February 9. While the peak appeared earlier, i.e. on February 5 in other provinces. It indicated that decisive outbreak control measures of the Chinese government are effective. While local governments should adjust management measures based on local risk level of epidemic. Although the epidemic has eased since late February, continued efforts in epidemic control are still needed to accelerate the end of the epidemic in China. However, the global COVID-19 epidemic outside China continues to expand as indicated by the epidemic trend index we proposed. In order to cope with the novel coronavirus pandemic, people all over the world should work together and governments of all countries should take efficient measures in the light of China's experience and according to national circumstances and local conditions.

    Metabolic disturbances MESHD and inflammatory dysfunction MESHD predict severity of coronavirus disease MESHD 2019 (COVID-19): a retrospective study

    Authors: Shuke Nie; Xueqing Zhao; Kang Zhao; Zhaohui Zhang; Zhentao Zhang; Zhan Zhang

    doi:10.1101/2020.03.24.20042283 Date: 2020-03-26 Source: medRxiv

    Background: The coronavirus disease MESHD 2019 (COVID-19) is spreading worldwide with 16,558 deaths till date. Serum SERO albumin, high-density lipoprotein (HDL-C), and C-reactive protein have been known to be associated with the severity and mortality of community-acquired pneumonia HP pneumonia MESHD. However, the characteristics and role of metabolic and inflammatory indicators in COVID-19 is unclear. Methods: We included 97 hospitalized patients with laboratory-confirmed COVID-19. Epidemiological, clinical, and laboratory indices; radiological features; and treatment were analysed. The differences in the clinical and laboratory parameters between mild and severe COVID-19 patients and the role of these indicators in severity prediction of COVID-19 were investigated. Results: All were Wuhan residents with contact with confirmed COVID-19 cases. The median age TRANS was 39 years (IQR: 30-59). The most common presenting symptoms were fever HP fever MESHD (58.8%), cough HP (55.7%), and fatigue HP fatigue MESHD (33%). Other features were lymphopenia HP lymphopenia MESHD, impaired fasting glucose, hypoproteinaemia MESHD, hypoalbuminemia HP hypoalbuminemia MESHD, low high-density lipoproteinemia MESHD. Decrease in lymphocyte count, serum SERO total protein, serum SERO albumin, high-density lipoprotein cholesterol (HDL-C), ApoA1, CD3+T%, and CD8+T% were found to be valuable in predicting the transition of COVID-19 from mild to severe illness. Chest computed tomography (CT) images showed that the absorption of bilateral lung lesions synchronized with the recovery of metabolic and inflammatory indicators. Conclusions: Hypoproteinaemia, hypoalbuminemia MESHD hypoalbuminemia HP, low high-density lipoproteinemia MESHD, and decreased ApoA1, CD3+T%, and CD8+T% could predict severity of COVID-19. Lymphocyte count, total serum SERO protein, and HDL-C may be potentially useful for the evaluation of COVID-19.

    Clinical characteristics of 57 patients infected with COVID-19 in Baodi area of Tianjin, China

    Authors: Yingchao Zhang; Zhentao Lin; Lijing Wang; Shuxiang Shan

    doi:10.21203/rs.3.rs-19003/v1 Date: 2020-03-24 Source: ResearchSquare

    BackgroundCoronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2) has been spreading worldwide.ObjectiveTo study the clinical characteristics of COVID-19, we included 57 real-time RT-PCR confirmed patients in Baodi area of Tianjin, China, admitted to hospital from 31 January 2020 and 22 February 2020.MethodsEpidemiological, demographic, clinical, and radiological features and laboratory data were analyzed. Patients were confirmed by real-time RT-PCR with pharyngeal swab and/or sputum samples. Some patients that presented positive results with sputum samples yielded negative results with multiple swab tests, suggesting sputum samples RT-PCR tests may be a more reliable means of positively diagnosing infected individuals.ResultsOf the 57 patients studied, three were mild and 54 were moderate in severity. None of the patients infected traveled TRANS to Wuhan indicating all studied cases were infected by human to human transmission TRANS. The most common symptoms at onset TRANS of illness were included fever HP fever MESHD (86%), cough HP (29.8%), myalgia HP myalgia MESHD or fatigue HP fatigue MESHD (14%), chest tightness HP chest tightness MESHD (5.3%), sore throat (5.3%), and diarrhea HP diarrhea MESHD (5.3%).ConclusionCompared with patients of COVID-19 in Wuhan, the symptoms of patients in Baodi area of Tianjin province are relatively mild.

    Clinical characteristics and reasons of different duration from onset to release from quarantine for patients with COVID-19 Outside Hubei province, China.

    Authors: Suochen Tian; Zhenqin Chang; Yunxia Wang; Min Wu; Wenming Zhang; Guijie Zhou; Xiuli Zou; Hui Tian; Tingfang Xiao; Junmin Xing; Juan Chen; Jian Han; Kang Ning; Tiejun Wu

    doi:10.1101/2020.03.21.20038778 Date: 2020-03-23 Source: medRxiv

    Objective: To find out more characteristics and rules of COVID-19 by analyzing the clinical course of COVID-19 patients in a region outside Hubei province. Methods: 37 cases diagnosed adult TRANS COVID-19 cases of general characteristics, history of epidemiology, chronic underlying diseases,clinical symptoms and complications, chest CT, biochemical monitoring, severity assessment, treatment and outcome were retrospectively analyzed, and according to the duration from onset to release from quarantine were divided into 20-day group and > 20-day group, compare the similarities and differences between the two groups. Results: Among the 37 patients, 5 were mild, 30 were moderate, 1 was severe and 1 was critical. All the patients were released from quarantine without death MESHD. The average duration from onset to release from quarantine was 20.2{+/-}6.6 days, The average length of stay from onset to hospitalization was 4.1{+/-}3.7 days, and hospitalization duration average 16.1{+/-} 6.2 days. The average age TRANS was 44.3{+/-}1.67 years. 78.4% of cases were caused by exposure to a confirmed patient or the workplace of a confirmed patient. The main symptoms were cough HP (67.6%), fever HP fever MESHD( 62.2%), shortness of breath MESHD (32.4%), fatigue HP fatigue MESHD (24.3%), sore throat (21.6%,) vomiting HP vomiting MESHD or diarrhea HP diarrhea MESHD (21.6%). The white blood SERO cell count was decreased in 27.0% of the patients, and the lymphocyte count was decreased in 62.2% of the patients, of which 43.5% patients were <0.6 x 109/L. On admission, 86.5% of patients with chest CT showed pneumonia HP pneumonia MESHD, including some asymptomatic TRANS patients. 68.8% of patients showed bilateral infiltration. In the > 20-day group, the average age TRANS was 49.9{+/-}1.38 years old, and the duration from onset to hospitalization was 5.5{+/-}3.9 days. Compared with the [≤]20-day group, the age was older TRANS and and duration was longer, P < 0.05. All the 7 asymptomatic TRANS patients were [≤]20-day group. When 37 patients were released from quarantine, the white blood SERO cell count of 16.2% patients was <4.0 x 109/L, and the lymphocyte count of 59.5% patients was <1.1x109/L, and the absolute count of white blood SERO cells and lymphocytes was 5.02 {+/-} 1.34x109/L and 1.03{+/-} 0.34x109/L respectively , compared with those on admission, P >0.05. Conclusion: The majority of COVID-19 cases in the study area were mild and moderate, with good clinical outcomes. There were some special characteristics in the clinical process. The reasons of duration from onset to release from quarantine were complex. There was no significant change in the number of granulocytes at the time of release from quarantine compared to the time of admission.

    A meta-analysis of clinical characteristics and mortality COVID-19 pneumonia HP pneumonia MESHD

    Authors: Shangxia Jiang; Yueming Wu; Tianzheng Lou; Junlong Xu; Yu Zhang; Hu Chen; Hewei Xu

    doi:10.21203/rs.3.rs-18723/v2 Date: 2020-03-21 Source: ResearchSquare

    Abstract: Objective To investigate the Corona Virus Disease MESHD 2019(COVID-19) clinical characteristics and mortality risk by pooling the open published data. Methods Studies relevant to COVID-19 published in Pubmed, China Wanfang database, ChinaXiv and medRxiv were systematic screened by using the text word of “COVID-19”, 2019-nCoV, “SARS-CoV-2”, “NCP”. The mortality and clinical characteristic of the COVID-19 cases such as male TRANS/ female TRANS ratio, mechanical ventilation ratio and top c linical symptom rate of the COVID-19 cases were pooled. Results Ten clinical studies relevant to COVID-19 were identified by electronic searching the related databases. The combined mortality was 0.03(95%CI: 0.01-0.04) for COVID-19 cases by random effect model. The pooled female TRANS ratio of the COVID-19 cases from 10 published data was 0.41(95%CI:0.37-0.46). The pooled invasive and non-invasive ventilation ratio were 0.03(95%CI:0.01-0.05) and 0.06(95%CI:0.02-0.09) respectively for patients with COVID-19 pneumonia HP pneumonia MESHD. The pooled clinical symptom rate of fever HP fever MESHD, cough HP cough MESHD, headache HP headache MESHD and fatigue HP fatigue MESHD were 0.80(95%CI:0.60-1.01), 0.12(95%CI:0.08-0.17), 0.68(95%CI:0.57-0.73) and 0.51(95%CI:0.36-0.67) respectively under random effect model. Conclusion According to the present published data, male TRANS was more cline to susceptible to COVID-19 compared to female TRANS. The fever HP fever MESHD, cough HP cough MESHD and fatigue HP fatigue MESHD were the most common symptom of COVID-19 cases. About 10% of patients received invasive or noninvasive mechanical ventilation with the overall crude mortality of 3%.

    Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

    Authors: Li-ping Fu; Yuan-tong Gao; Ke Zhou; Min Luo; Peng-Cheng Ma; Fa-Huan Song; Yong-chou Li

    doi:10.21203/rs.3.rs-18696/v1 Date: 2020-03-20 Source: ResearchSquare

    Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia MESHD” caused by a novel coronavirus strain infection MESHD and was dubbed the COVID-19 by the WHO. The disease quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis. Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020. Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled TRANS from Wuhan City. The median time from onset of symptoms TRANS to first hospital admission was 3.9±1.9 days. The initial symptoms included fever HP fever MESHD (46/64), dry cough MESHD cough HP (38/64), fatigue HP fatigue MESHD or myalgia HP myalgia MESHD (23/64), sore throat (10/64), diarrhea HP diarrhea MESHD (3/64) along with late- onset symptoms TRANS like chest pains HP chest pains MESHD (2/64) and headaches HP headaches MESHD (2/64). The majority of the patients (43/64) had normal white blood SERO cell counts while 29.7 % (19/64) had leukopenia HP leukopenia MESHD. Only two patients (3.1 %) presented with leukocytosis HP leukocytosis MESHD. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection MESHD (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death so far. Conclusions: Early intervention in COVID-19 disease improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

    Clinical and CT imaging characteristics of COVID-19 cases in Wenzhou city: A retrospective analysis

    Authors: Li-ping Fu; Yuan-tong Gao; Ke Zhou; Min Luo; Peng-Cheng Ma; Fa-Huan Song; Yong-chou Li

    doi:10.21203/rs.3.rs-18096/v1 Date: 2020-03-19 Source: ResearchSquare

    Background: In December 2019, Wuhan witnessed the outbreak of an “unexplained pneumonia MESHD” caused by a novel coronavirus strain infection MESHD and was dubbed the COVID-19 by the WHO. The disease quickly spread to China. This study aimed to investigate the disease’s evolving epidemiological history, as well as analyze the clinical and CT imaging characteristics, treatment regimens, and patients’ prognosis.Methods: This was a retrospective study whose cases were 64 patients with a confirmed diagnosis of COVID-19. The clinical data were obtained from patients who were admitted to the isolation ward from 21 January 2020 to 19 February 2020.Results: 60 out of 64 patients had a definitive history of exposure to people who had traveled TRANS from Wuhan City. The median time from onset of symptoms TRANS to first hospital admission was 3.9±1.9 days. The initial symptoms included fever HP fever MESHD (46/64), dry cough MESHD cough HP (38/64), fatigue HP fatigue MESHD or myalgia HP myalgia MESHD (23/64), sore throat (10/64), diarrhea HP diarrhea MESHD (3/64) along with late- onset symptoms TRANS like chest pains HP chest pains MESHD (2/64) and headaches HP headaches MESHD (2/64). The majority of the patients (43/64) had normal white blood SERO cell counts while 29.7 % (19/64) had leukopenia HP leukopenia MESHD. Only two patients (3.1 %) presented with leukocytosis HP leukocytosis MESHD. 58 of the 64patients had abnormal radiological findings on chest CTs. The first chest CTs (within 2 days) was more sensitive in detecting COVID-19 infection MESHD (85.9 %) compared to the initial RT-PCR (56.3 %; p<0.01). The CTs showed lesions in multiple lung lobes in three-quarters of the patients while 15.6 % had lesions localized to one lobe. Most of the lesions were typically dense with ground-glass opacity co-existing with consolidation or cord-like shadows. Most of these patients (50/64) have recovered and got discharged giving a mean length of hospital stay of 13.5±4.8 days. Our hospital unit has not reported any COVID-19 related death so far. Conclusions: Early intervention in COVID-19 disease improves patients’ prognosis. Our data demonstrate the superiority of early radiological tests ahead of RT-PCR. The initial and dynamic CT changes in COVID-19 patients along with other clinical data shared above can better guide clinical decision making.

    Epidemiological and clinical characteristics of COVID-19 patients in Nanjing

    Authors: Wei Chen; Chunmei Hu; Lili Huang; Min Cai; Yongchen Zhang; Hongxia Wei; Yun Chi; Zhiliang Hu; Yi Zeng; Yishan Zheng; Ying Liu; Cong Cheng; Hongmei Zhang; Weixiao Wang; Xia Zhang; Yongxiang Yi

    doi:10.21203/rs.3.rs-18007/v1 Date: 2020-03-18 Source: ResearchSquare

    Background: Since December 2019, the outbreak of COVID-19 has spread quickly and thumped many countries and regions. The epidemic of central China was under the spotlight and attracted much more attentions. However, there are few reports describing COVID-19 patients in the regions outside of Wuhan, which are undergoing the change from sporadic imported cases to community-acquired transmission TRANS.Methods: The electronic medical records of 74 laboratory-confirmed patients of COVID-19 were retrospectively reviewed and analyzed. Their epidemiological, demographic, clinical and radiological characteristics were systematically summarized. The difference between severe patients and non-severe patients were also analyzed statistically.Results: The 74 COVID-19 patients were composed of 4 (5.4%) mild patients, 56 (75.7%) common patients, 13 (17.6%) severe patients and 1 (1.4%) critical patient. 43 were male TRANS, and 31 were female TRANS, with the average age TRANS 48.1±17.5. No significant difference of susceptibility was observed between genders TRANS, and almost people with all age TRANS were susceptible to SARS-CoV-2 infection MESHD. Before Jan 26, only imported sporadic cases were observed. However, from that day onward, family cluster infection MESHD cases increased dramatically, up to 70.3% (52/74), which were mainly from 15 family. The incubation period TRANS spanned from 0 to 19 days, with the median 5, and 81.4% had symptom onset TRANS within 7 days. At admission, 31.1% of patients had underlying diseases MESHD and the most common underlying diseases were hypertension HP hypertension MESHD (13.5%) and diabetes MESHD (5.4%). The most common symptoms were fever HP fever MESHD (90.5%), cough HP (75.7%), fatigue HP fatigue MESHD (36.5%) and chest distress (32.4%). 36.5% and 16.2% of patients had leukopenia HP leukopenia MESHD and lymphocytopenia MESHD. 43.2% of patients had increased C reactive protein (CRP), and 40.5% had higher erythrocyte sedimentation rate (ESR) and 21.6% had higher calcitonin. 74.3% of patients had obvious lesions in both lung lobes MESHD and 56.8% of lesions manifested as ground glass opacity. Compared with non-severe group, the severe/critical group were significantly older and had more underlying diseases. After treatment, all patients improved and were discharged. No medical professional infection MESHD and death case were reported.Conclusion: The epidemic of COVID-19 in Nanjing were mainly caused by family cluster infection MESHD. The entire prevalence SERO and illness were much milder than those of Wuhan. The disease of COVID-19 could be controlled and cured.  

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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