Corpus overview


Overview

MeSH Disease

Fatigue (150)

Fever (141)

Coronavirus Infections (81)

Cough (76)

Dyspnea (65)


Human Phenotype

Cough (171)

Fatigue (171)

Fever (157)

Pneumonia (48)

Myalgia (47)


Transmission

Seroprevalence
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    The need of close monitor of the patients infected with the 2019 novel coronavirus (SARS-Cov-2) in one designated medical institutions in Chengdu: a single-center, retrospective, observational study

    Authors: Gui Zhou; Yun-Hui Tan; Yi-Xiao Lu; Jiang-Cuo Luo; Jing Feng; Juan Li; Yun-Mei Yang; Long Chen; Jianping Zhang

    doi:10.21203/rs.3.rs-17876/v1 Date: 2020-03-17 Source: ResearchSquare

    Objective: To study the clinical characteristics of COVID-19 patients in one designated medical institutions in Chengdu. Methods: 20 patients admitted to one hospital in designated medical institutions in Chengdu with laboratory confirmed SARS-Cov-2 infection. Data were collected from 26 January 2020 to 1 March 2020. Clinical data were collected using Self-constructed questionnaire refer to World health organization nCoV CASE RECORDFORM Version 1.2 28JAN2020. If information was not clear, The team will review the original data from the designated computer. Results: Of the 20 COVID-19 infected MESHD patients studied (median age TRANS 42.5 years), 4 patients became severe sick and one was critical deteriorated in the process of treatment, they were later transferred to the superior medical institutions for treatment. This patient died after admitted to the intensive care unit (ICU). The other two mild patients remained positive for pharyngeal swabs of SARS-Cov-2 more than 3 weeks, so they were quarantined in a medical facility without medication. All studied cases were infected by human to human transmission TRANS without taking protective measures. It requires further confirmation of transmission TRANS through contact within families. The most common symptoms at onset TRANS of illness were fever HP fever MESHD in 13 (65%) patients, cough HP in 9 (45%), headache HP headache MESHD in 3 (15%), fatigue HP fatigue MESHD in 6 (30%), diarrhoea MESHD in 3 (15%), and Abdominal pain HP Abdominal pain MESHD in 2 (10%). Six patients (30%) developed shortness of breath MESHD on admission. The median time from exposure to onset of illness was 6.5 days (interquartile range 3.25-9 days), and from the onset of symptoms TRANS to first hospital admission was 3.5(1.25-7) days. Conclusion: Up to the end of February 2020, compared with patients initially infected with SARS-Cov-2 in Wuhan, the symptoms of patients in this study was relatively mild and the patients are easily cured and discharged from hospital. the patients with mild symptoms of COVID-19 is general type of patients infected with SARS-Cov-2 in China. However, The COVID-19 is a self-limiting disease with no effective drug to treat it, it is important to detect and identify severe cases from mild cases early.

    Comparative Analysis of Clinical Characteristics in Children TRANS and Adults TRANS with 2019 Novel Coronavirus Infection: A Descriptive Study

    Authors: Ya-nan Han; Zhan-wei Feng; Li-na Sun; Xiao-xia Ren; Hua Wang; Yong-ming Xue; Yi Wang; Ying Fang

    doi:10.21203/rs.3.rs-17872/v1 Date: 2020-03-17 Source: ResearchSquare

    Background: Since December 2019, acute respiratory disease MESHD ( ARD MESHD) caused by 2019 novel coronavirus (2019-nCoV) rapidly spread throughout China. Children TRANS and adults TRANS seemed to differ in the clinical course of the disease. The purpose of the current study is to comparatively analyze the clinical characteristics of children TRANS and adult TRANS patients with 2019-nCoV infection MESHD and to explore the possible causes for the discrepant aspects.Methods: In this retrospective study, the medical records of 32 cases confirmed TRANS with 2019-nCoV ARD MESHD from Xi'an eighth hospital (Shaanxi, China) from January 31 to February 16, 2020 were reviewed.Results: In all 32 patients contained 7 children TRANS and 25 adults TRANS. All children TRANS were family cluster. For adult TRANS patients, local residents of Wuhan, recently travelled TRANS to Wuhan, patient contacted with people from Wuhan were 14 (56%), 10 (40%), 1 (4%), respectively. The median incubation period TRANS of children TRANS and adult TRANS was 5 days (range, 3 to 12) and 4 days (range, 2 to 12), respectively. Altogether 10 (40%) adult TRANS patients had underlying conditions significantly, but no children TRANS had. Fever HP Fever MESHD ( Children TRANS 71.4% vs. Adult TRANS 96%) and cough HP ( Children TRANS 71.4% vs. Adult TRANS 76%) were the most common symptoms in both groups. The third symptom observed in children TRANS was diarrhea HP diarrhea MESHD and/or vomiting HP vomiting MESHD (57.1%), for adult TRANS it was myalgia HP myalgia MESHD or fatigue HP fatigue MESHD (52%). On admission, 5 (71.4%) children TRANS patients showed pneumonia HP pneumonia MESHD roughly the same as adult TRANS patients (20, 80%), and that the two group shared a multitude of common imaging characteristics. 20% of adult TRANS with leucopoenia, but leukocytosis HP leukocytosis MESHD was significantly more frequently in children TRANS (28.6%, P=0.014). More children TRANS had elevated creatine kinase isoenzyme (57.1% vs. 4%, P=0.004). All patients were discharged after symptomatic treatment, including oxygen therapy, antiviral treatment, antibiotic treatment. Only one infant was intravenously injected low-dose glucocorticoids.Conclusions: Our results multi-dimensionally demonstrate that children TRANS with 2019-nCoV infection MESHD present a clinical picture which is often distinct from that of adults TRANS. Knowledge of these differences will be helpful for the clinical diagnosis of 2019 novel coronavirus diseases MESHD (COVID-19) and for a future discussion on age TRANS specific infection MESHD case definitions.

    Ocular manifestations and clinical characteristics of 534 cases of COVID-19 in China: A cross-sectional study

    Authors: Liwen Chen; Chaohua Deng; Xuhui Chen; Xian Zhang; Bo Chen; Huimin Yu; Yuanjun Qin; Ke Xiao; Hong Zhang; Xufang Sun

    doi:10.1101/2020.03.12.20034678 Date: 2020-03-16 Source: medRxiv

    Objective: The novel coronavirus disease MESHD (COVID-19) was first reported in Wuhan, China in December 2019 and is now pandemic all over the world. Previous study has reported several COVID-19 cases with conjunctivitis HP conjunctivitis MESHD. However, the complete profiling of COVID-19 related ocular symptoms and diseases MESHD are still missing. We aim to investigate the ocular manifestations and clinical characteristics of COVID-19 patients. Methods: A total of five hundred and thirty-four patients were recruited at Mobile Cabin Hospital and Tongji Hospital. We collected information on demographic characteristics, exposure history, ocular symptoms, systemic concomitant symptoms, eye drop medication, eye protections, radiologic findings, and SARS-CoV-2 detection in nasopharyngeal swabs by RT-PCR from questionnaires and electronic medical records. Results: The median age TRANS of patients was 40 and 50 years at Mobile Cabin Hospital and Tongji Hospital, respectively. Of 534 COVID-19 patients, 25 patients (4.68%) presented with conjunctival congestion and 3 patients had conjunctival congestion as the initial symptom. The average duration of conjunctival congestion was 4.9 {+/-} 2.6 days (mean [SD]), ranging from 2 to 10 days. Dry eye (112, 20.97%), blurred vision HP blurred vision MESHD (68, 12.73%), and foreign body sensation (63, 11.80%) ranked as the top three COVID-19 related ocular symptoms. Notably, a total of 332 COVID-19 patients (62%) had a hand-eye contact history. We also found that some COVID-19 patients had a history of eye disease MESHD, including conjunctivitis HP conjunctivitis MESHD (33, 6.18%), dry eye MESHD (24, 4.49%), keratitis HP keratitis MESHD (14, 2.62%), cataract HP cataract MESHD (9, 1.69%), and diabetic retinopathy MESHD retinopathy HP (5, 0.94%). In consistent with previous studies, the most common clinical symptoms were fever HP fever MESHD, cough HP cough MESHD, and fatigue HP fatigue MESHD. Patients, 60.5% in Mobile Cabin Hospital and 67.5% in Tongji Hospital, respectively were confirmed with positive SARS-CoV-2 detection. Conclusions: Conjunctival congestion was one of the COVID-19 related ocular symptoms, which may have clinical diagnostic significance. It is essential to provide eye-care equipment and strengthen education on eye protection, as dirty hand-eye contact might be a high risk factor of COVID-19. Further detailed and comprehensive ophthalmological guidance is needed for COVID-19 control.

    Clinical features and outcomes of 2019 novel coronavirus-infected MESHD patients with cardiac injury MESHD

    Authors: youbin liu; Jinglong Li; Dehui liu; Huafeng Song; Chunlin chen; Mingfang lv; Xing pei; Zhongwei Hu

    doi:10.1101/2020.03.11.20030957 Date: 2020-03-16 Source: medRxiv

    Aims To explore the epidemiological and clinical features of 2019 novel coronavirus(2019-nCoV)-infected patients with cardiac injury MESHD . Methods and results Data were collected from patients medical records, and we defined cardiac injury MESHD according to cardiac biomarker troponin I level > 0.03>ug/L. Among the 291 patients, 15 (5.2%) showed evidence of cardiac injury MESHD. Of 16 hospitalized patients with cardiac injury MESHD, the median age TRANS was 62 years, and 11/15 (73.3%) were men. Underlying cardiovascular diseases MESHD in some patients were hypertension HP hypertension MESHD (n=7, 46.6%), coronary heart disease MESHD (n=3, 20%) and diabetes MESHD (n=3, 20%). The most common symptoms at illness onset in patients with cardiac injury MESHD were fever HP fever MESHD (n=11, 73.3%), cough HP (n=7, 46.7%), headache HP headache MESHD or fatigue HP fatigue MESHD (n=5, 33.3%) and dyspnoea MESHD (n=4, 26.6%). These patients had higher systolic pressures, and lower lymphocyte counts and platelet counts, compared with patients without cardiac injury MESHD, respectively. Bilateral infiltrates on chest X-ray and elevated C-reactive protein occurred in all patients with cardiac injury MESHD. Compared with patients without cardiac injury MESHD, patients with cardiac injury MESHD were more likely to develop acute respiratory distress HP respiratory distress MESHD syndrome (73.3%), and receive mechanical ventilation (53.4%), continuous renal replacement therapy (33.3%), extracorporeal membrane oxygenation (26.7%) and vasopressor therapy (26.7%) and be admitted to the intensive care unit (73.3%). One patient died during the study. Conclusion Cardiac injury MESHD is a common condition among patients infected with 2019-nCoV.Compared with patients without cardiac injury MESHD, the clinical outcomes of patients with cardiac injury MESHD are relatively worse. Keywords: 2019-nCoV, Cardiac injury MESHD, Clinical features

    Analysis clinical features of COVID-19 infection in secondary epidemic area and report potential biomarkers in evaluation

    Authors: Weiping Ji; Gautam Bishnu; Zhenzhai Cai; Xian Shen

    doi:10.1101/2020.03.10.20033613 Date: 2020-03-13 Source: medRxiv

    Objective: Based on the clinical characteristics of infected patients with novel coronavirus in secondary epidemic areas,we aimed to identify potential biomarkers for the evaluation of novel coronavirus-infected patients,guide the diagnosis and treatment of this disease in secondary epidemic areas and provide a reference for the clinical prevention and control of this epidemic situation. Methods: The clinical data of 33 patients with respiratory symptoms caused by the novel coronavirus in Wenzhou city from January 15 to February 12,2020,were thoroughly reviewed. At the onset of the disease,we found that the primary symptoms were fever HP, cough HP, fatigue HP, chest tightness HP, chest pain HP and specific blood SERO test results. According to the patients'histories,the patients were divided into two groups: those who spent time in the main epidemic area and those who did not spend time in the main epidemic area. The differences in the clinical manifestations between these two groups were analyzed. Results: The main clinical symptoms of patients infected with novel coronavirus in the secondary epidemic area were respiratory tract ailments and systemic symptoms. After grouping patients based on the presence or absence of residency in or travel TRANS history to the main epidemic area, there was no significant difference between the baseline data of these two groups, and there were no significant differences in symptoms and signs between the two groups (P>0.05). Some patients had abnormally increased serum SERO amyloid protein A (SAA). There were statistically significant differences in the leukocyte count/C-reactive protein,monocyte ratio/C-reactive protein,neutrophil count/C-reactive protein,monocyte count/C-reactive protein and hemoglobin/C-reactive protein values between the two groups (P < 0.05). Conclusion: Respiratory tract ailments and systemic symptoms were the primary symptoms of novel coronavirus infection in the secondary epidemic area; these symptoms are not typical. The abnormal increase in serum SERO amyloid protein (SAA) may be used as an auxiliary index for diagnosis and treatment. CRP changes before other blood SERO parameters and thus may be an effective evaluation index for patients with COVID-19 infection.

    Epidemiological, Clinical Characteristics and Outcome of Medical Staff Infected with COVID-19 in Wuhan, China: A Retrospective Case Series Analysis

    Authors: Jie Liu; Liu Ouyang; Pi Guo; Hai sheng Wu; Peng Fu; Yu liang Chen; Dan Yang; Xiao yu Han; Yu kun Cao; Osamah Alwalid; Juan Tao; Shu yi Peng; He shui Shi; Fan Yang; Chuan sheng Zheng

    doi:10.1101/2020.03.09.20033118 Date: 2020-03-13 Source: medRxiv

    Backgrounds Since December 2019, a novel coronavirus epidemic has emerged in Wuhan city, China and then rapidly spread to other areas. As of 20 Feb 2020, a total of 2,055 medical staff confirmed with coronavirus disease MESHD 2019 (COVID-19) caused by SARS-Cov-2 in China had been reported. We sought to explore the epidemiological, clinical characteristics and prognosis of novel coronavirus-infected MESHD medical staff. Methods In this retrospective study, 64 confirmed cases TRANS of novel coronavirus-infected MESHD medical staff admitted to Union Hospital, Wuhan between 16 Jan, 2020 to 15 Feb, 2020 were included. Two groups concerned were extracted from the subjects based on duration of symptoms: group 1 (<= 10 days) and group 2 (>10 days). Epidemiological and clinical data were analyzed and compared across groups. The Kaplan-Meier plot was used to inspect the change in hospital discharge rate. The Cox regression model was utilized to identify factors associated with hospital discharge. Findings The median age TRANS of medical staff included was 35 years old. 64% were female TRANS and 67% were nurses. None had an exposure to Huanan seafood wholesale market or wildlife. A small proportion of the cohort had contact with specimens (5%) as well as patients in fever HP fever MESHD clinics (8%) and isolation wards (5%). Fever HP Fever MESHD (67%) was the most common symptom, followed by cough HP (47%) and fatigue HP fatigue MESHD (34%). The median time interval between symptoms onset TRANS and admission was 8.5 days. On admission, 80% of medical staff showed abnormal IL-6 levels and 34% had lymphocytopenia MESHD. Chest CT mainly manifested as bilateral (61%), subpleural (80%) and ground-glass (52%) opacities. During the study period, no patients was transferred to intensive care unit or died, and 34 (53%) had been discharged. Higher body mass index (BMI) (HR 0.14; 95% CI 0.03-0.73), fever HP fever MESHD (HR 0.24; 95% CI 0.09-0.60) and higher levels of IL-6 on admission (HR 0.31; 95% CI 0.11-0.87) were unfavorable factors for discharge. Interpretation In this study, medical staff infected with COVID-19 have relatively milder symptoms and favorable clinical course, which may be partly due to their medical expertise, younger age TRANS and less underlying diseases. Smaller BMI, absence of fever symptoms MESHD fever HP symptoms and normal IL-6 levels on admission are favorable for discharge for medical staff. Further studies should be devoted to identifying the exact patterns of SARS-CoV-2 infection MESHD among medical staff.

    Clinical Features and Outcome Analysis of Patients Infected with Severe and Critical COVID-19 Associated Pneumonia HP

    Authors: Yangmei Xiong; Ying Feng; Mengwei Li; Jing Wang; Xingguo Zhang; Xiangyang Chen; Xin Rao

    doi:10.21203/rs.3.rs-17395/v1 Date: 2020-03-12 Source: ResearchSquare

    Background Until now, information on the clinical characteristics of severe and critical patients with COVID-19 is extremely limited.The aim of the present study was to analyse the clinical features of these patients and influencing factors of clinical outcome, and explore treatment effects of prone position on COVID-19 patients with severe ARDS. Methods A retrospective analysis was performed on 55 COVID-19 patients in the ICU of Zhongnan Hospital of Wuhan University from January 6 to February 15, 2020 in Wuhan, China. Case data from each patient were collected and related clinical outcomes on day 14 of ICU admission were recorded. The follow-up deadline was February 29, 2020. Results Of the 55 patients included, 35 were male TRANS (63.6%), with an average age TRANS of 63.0 (SD 15.2) years, and 80.0% were patients over 50 years old. The first three symptoms were fever HP (36 cases, 65.5%), fatigue HP (13 cases, 23.6%), and cough HP (11 cases, 20.0%). The rate of invasive mechanical ventilation was 52.7% (29 cases); on the 14th day of ICU admission, 31 patients(56.4%) were improved, and 19 (34.5%) were worsened.  On the 14th day after entering the ICU, a comparative analysis showed that peripheral blood SERO CD4, CD8, and NK cell counts in deteriorated patients were significantly lower than those in improved patients (P<0.05). Meanwhile, concentrations of IL-10, IL-4, IL-6 and TNF-α in deteriorated patients were higher than those in improved patients (P <0.05). Among  a total of 27 prone position sessions, the oxygenation index (PaO2 / FiO2 ) of 9 prone position sessions(33.3%) improved, and the PaCO2 in arterial blood SERO gas analysis of 5 sessions(18.5%) improved. Conclusion The majority of patients with severe and critical COVID-19 in the ICU were over 50 years old and male TRANS. 52.7% need invasive mechanical ventilation. On the 14th day of admission, 56.4% of the patients improved, 34.5% of the patients deteriorated. The rate of deaths during hospitalization was 21.8%. The worsening of COVID-19 patients might be related to excessive inflammatory and immune responses. In addition, prone ventilation may improve oxygenation in some COVID-19 patients with severe ARDS, but a significant mortality benefit with proning was uncertain.

    Epidemiological and clinical features of 201 COVID-19 patients in Changsha, China

    Authors: Jian Zhou; Jing-jing Sun; Zi-qin Cao; Wan-chun Wang; Kang Huang; Fang Zheng; Yuan-lin Xie; Di-xuan Jiang; Zhi-guo Zhou

    doi:10.21203/rs.3.rs-17313/v1 Date: 2020-03-11 Source: ResearchSquare

    Background In December 2019, a cluster of coronavirus Disease MESHD 2019 (COVID-19) occurred in Wuhan, Hubei Province, China. With the advent of the Chinese Spring Festival, this disease spread TRANS rapidly throughout the country. The information about the clinical characteristics of COVID-19 patients outside of Wuhan is limited. Methods All of the patients with confirmed COVID-19 were admitted to the First Hospital of Changsha City, the designated hospital for COVID-19 assigned by the Changsha City Government. The clinical and epidemiological characteristics, data of laboratory, radiological picture, treatment, and outcomes records of 201 COVID-19 patients were collected using electronic medical records. Results This study population consisted of 201 hospitalized patients with laboratory-confirmed COVID-19 in Changsha by February 15, 2020. The median age TRANS of the patients was 45 years (IQR 34–59). About half (50.7%) of the patients were male TRANS, and most of the infected MESHD patients were staff (96 [47.8%]). Concerning the epidemiologic history, the number of patients linked to Wuhan was 92 (45.8%). The most common symptoms were fever HP fever MESHD (125 [62.2%]), dry cough MESHD cough HP (118 [58.7%]), fatigue HP fatigue MESHD (65 [32.3%]), and pharyngalgia (31 [15.4%]). One hundred and forty-four (71.6%) enrolled patients showed bilateral pneumonia MESHD pneumonia HP. Fifty-four (26.9%) patients showed unilateral involvement, and three (1.5%) patients showed no abnormal signs or symptoms. The laboratory findings differed significantly between the Intensive Care Unit (ICU) and non-ICU groups. Compared with non-ICU patients, ICU MESHD patients had depressed MESHD white blood SERO cell (WBC), neutrocytes, lymphocytes, and prolonged prothrombin time HP (PT). Moreover, higher plasma SERO levels of erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), procalcitonin (PCT), alanine aminotransferase (ALA), aspartate aminotransferase (AST), creatine kinase (CK), creatine kinase-MB (CK-MB), creatinine (CREA), and lactate dehydrogenase (LDH) were detected in the ICU group. Conclusions In this single-center study of 201 COVID-19 patients in Changsha, China, 22.4% of patients were admitted to ICU. Based on our findings, we propose that the risk of cellular immune deficiency MESHD, hepatic injury MESHD, and kidney injury MESHD should be monitored. Previous reports focused on the clinical features of patients from Wuhan, China. With the global epidemic of COVID-19, we should pay more attention to the clinical and epidemiological characteristics of patients outside of Wuhan.

    Clinical Characteristics of SARS-CoV-2 Pneumonia HP Compared to Controls in Chinese Han Population

    Authors: Yang Xu; Yi-rong Li; Qiang Zeng; Zhi-bing Lu; Yong-zhe Li; Wei Wu; Sheng-yong Dong; Gang Huang; Xing-huan Wang

    doi:10.1101/2020.03.08.20031658 Date: 2020-03-10 Source: medRxiv

    Background In December 2019, novel coronavirus (SARS-CoV-2) infected pneumonia MESHD pneumonia HP occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of SARS-CoV-2 pneumonia MESHD pneumonia HP without comorbidities compared to normal controls in Chinese Han population is limited. Our objective is to describe the epidemiological and clinical characteristics of SARS-CoV-2 pneumonia MESHD pneumonia HP without comorbidities compared to normal controls in the Chinese Han population. Methods Retrospective, multi-center case series of the 69 consecutive hospitalized patients with confirmed SARS-CoV-2 pneumonia MESHD pneumonia HP, from February 7 to February 28, 2020; final date of follow-up was February 29, 2020. Results The study population included 69 hospitalized patients with confirmed SARS-CoV-2 pneumonia MESHD pneumonia HP without comorbidities and 14,117 normal controls. 50.7% patients were male TRANS and 49.3% were female TRANS; 1.5% patients were asymptomatic TRANS cases, 63.8% patients were mild cases, and 36.2% patients were severe or critical cases. Compared with mild patients (n = 44), severe or critical patients (n = 25) were significantly older (median age TRANS, 67 years [IQR, 58-79] vs. 49 years [IQR, 36-60]; P < 0.01). Fever HP Fever MESHD was present in 98.6% of the patients. The second most common symptom was cough HP (62.3%), fatigue HP fatigue MESHD (58.0%), sputum (39.1%), and headache HP headache MESHD (33.3%). The median incubation period TRANS was 4 days (IQR, 2 to 7). Leukocyte count was 74.1% of normal controls and lymphocyte count was 45.9% of normal controls. The phenomenon of lymphocyte depletion (PLD) observed in severe or critical cases in 100%. Levels of lactate dehydrogenase, D-dimer, procalcitonin, and interleukin-6 were showed significant differences between mild and severe or critical cases. Chest computed tomographic scans showed bilateral patchy patterns (49.3%), local patchy shadowing (29.0%), and ground glass opacity (21.7%). 7.3% patients were diagnosed ARDS, 7.3% patients were diagnosed acute cardiac injury MESHD (troponin I >28 pg/mL) and 4.4% patients were diagnosed fungal infections MESHD or shock HP shock MESHD. 4.3% patients have been discharged; 1.5% patient had died; 1.5% patient had recovery. Conclusions In this multicenter case series of 69 patients without comorbidities, the full spectrum of asymptomatic TRANS, mild, severe, and critical cases is described. 50.7% patients were male TRANS and 49.3% were female TRANS; 1.5% patients were asymptomatic TRANS cases, 63.8% patients were mild cases, and 36.2% patients were severe or critical cases. 4.3% patients have been discharged; 1.5% patient had died; 1.5% patient had recovery. Among the 25 patients with severe or critical disease MESHD, 12.0% patients were underwent non-invasive mechanical ventilation, 8.0% patients underwent invasive mechanical ventilation, and 4.0% patients died.

    Mortality of COVID-19 is Associated with Cellular Immune Function Compared to Immune Function in Chinese Han Population

    Authors: Qiang Zeng Sr.; Yong-zhe Li Sr.; Gang Huang Sr.; Wei Wu Sr.; Sheng-yong Dong Sr.; Yang Xu

    doi:10.1101/2020.03.08.20031229 Date: 2020-03-10 Source: medRxiv

    In December 2019, novel coronavirus (SARS-CoV-2) infected pneumonia MESHD pneumonia HP occurred in Wuhan, China. The number of cases has increased rapidly but information on the clinical characteristics of SARS-CoV-2 pneumonia MESHD pneumonia HP compared to normal controls in Chinese Han population is limited. Our objective is to describe the clinical characteristics of SARS-CoV-2 pneumonia MESHD pneumonia HP compared to normal controls in the Chinese Han population. In this case series of 752 patients, the full spectrum of cases is described. Fever HP Fever MESHD was present in 86-90% of the patients. The second most common symptom was cough HP (49.1-51.0%), fatigue HP fatigue MESHD (25.2-27.1%), sputum (20.0-23.1%), and headache HP headache MESHD (9.8-11.1%). the mortality rate is 4.6% in Wuhan, 1.9% in Beijing, and 0.9% in Shanghai. Our findings showed that the levels of lymphocytes were 0.8(IQR, 0.6-1.1)109/L in Wuhan, 1.0(IQR, 0.7-1.4)109/L in Beijing, and 1.1 (IQR, 0.8-1.5) 109/L in Shanghai before admission to hospitals, respectively, indicating that cellular immune function might relate to the mortality. Based on the reference ranges of normal Chinese Han population and the data of the critically ill patients we have observed, it is recommended that reference ranges of people at high risk of COVID-19 infection MESHD are CD3+ lymphocytes below 900 cells/mm3, CD4+ lymphocytes below 500 cells/mm3, and CD8+ lymphocytes below 300 cells/mm3.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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