Corpus overview


MeSH Disease

Fatigue (147)

Fever (140)

Coronavirus Infections (81)

Cough (74)

Dyspnea (63)

Human Phenotype

Cough (168)

Fatigue (168)

Fever (156)

Pneumonia (48)

Myalgia (47)


    displaying 41 - 50 records in total 168
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    Preparedness and Approaches of Healthcare Providers to Tackle the Transmission TRANS of Covid-19 among North Shewa Zone Hospitals, Amhara, Ethiopia, 2020.

    Authors: Getaneh Baye Mulu; worku Misganaw Kebede; Solomon Adanew worku; Yohannes Moges Mittiku; Birhanu Ayelign Jemere

    doi:10.21203/ Date: 2020-06-16 Source: ResearchSquare

    Background Coronavirus disease 2019 (COVID-19 is an emerging respiratory disease that is caused by a novel coronavirus and was first detected in December 2019 in Wuhan, China. The disease is highly infectious, and its main clinical symptoms include fever HP, dry cough HP, fatigue HP, myalgia HP, and dyspnea HP. Health care providers are in front in fighting the coronavirus spread by making themselves the risk of contracting the disease. This study aimed to assess the preparedness and approaches of healthcare providers to tackle the transmission TRANS of COVID-19 among North Shewa Zone Hospitals.Methods Facility-based cross-sectional study was conducted from April to May 2020 among 422 healthcare providers in the North Shewa Zone, Amhara, Ethiopia using a self-administered questionnaire. Study subjects were selected through systematic random sampling based on their proportional distribution of sample size to each hospital. A structured questionnaire will be used to collect data. The data were coded and entered into the Epi data 4.2.1 version and the analysis was carried out in statistical package for social science 25 versions.Results 404 participants involved in the study gives a response rate of 95.7%. The self-satisfaction of healthcare providers revealed 301 (74.5%) of study participants feel unsafe in their workplace. Two-third, 260 (64.4%) of them responded that they feel anxious while working with febrile patients. Nearly one -third (31%), 27.4%, 15.9%, 14.5%, 14.2% of HCP had access to gloves, facemask, goggle, shoe, and apron respectively in hospitals.Conclusion Protecting healthcare workers is a public health priority. Access to essential personal protective equipment during the COVID-19 pandemic was limited. The poor perception of healthcare professionals about not having enough support from medical institutions and public health authorities raises the need to urgently implement strategies to protect healthcare workers in the time of the COVID-19 pandemic.

    Critical Complications of COVID-19: A systematic Review and Meta-Analysis study

    Authors: Kimia Vakili; Mobina Fathi; Fatemeh Sayehmiri; Ashraf Mohamadkhani; Mohammadreza Hajiesmaeili; Mostafa Rezaei-Tavirani; Aiyoub Pezeshgi

    doi:10.1101/2020.06.14.20130955 Date: 2020-06-16 Source: medRxiv

    Background: Coronavirus disease 2019 (COVID-19) is a novel coronavirus infection MESHD that has spread worldwide in a short period and caused a pandemic. The goal of this meta-analysis is to evaluate the prevalence SERO of most common symptoms and complications of COVID-19. Methods: All related studies assessing the clinical complications of COVID-19 have been identified through web search databases (PubMed and Scopus). Relevant data were extracted from these studies and analyzed by stata (ver 14) random-effects model. The heterogeneity of studies were assessed by I2 index. The publication bias was examined by Funnel plots and Eggers test. Results: 30 studies were in our meta-analysis including 6 389 infected MESHD patients. The prevalence SERO of most common symptoms were: fever HP 84.30% (95% CI: 77.13-90.37; I2=97.74%), cough HP 63.01% (95% CI: 57.63-68.23; I2=93.73%), dyspnea HP dyspnea MESHD 37.16% (95% CI: 27.31-47.57%; I2=98.32%), fatigue HP fatigue MESHD 34.22% (95% CI: 26.29-42.62; I2=97.29%) and diarrhea HP diarrhea MESHD 11.47 %(95% CI: 6.96-16.87; I2=95.58%), respectively. The most prevalent complications were acute respiratory distress HP syndrome (ARDS) 33.15% (95% CI: 23.35-43.73; I2=98.56%), acute cardiac injury 13.77% (95% CI: 9.66-18.45; I2=91.36%), arrhythmia HP 16.64% (95% CI: 9.34-25.5; I2=92.29%), heart failure 11.50% (95% CI: 3.45-22.83; I2=89.48%), and acute kidney injury HP (AKI) 8.40 %(95% CI: 5.15-12.31; I2=95.22%, respectively. According to our analysis, mortality rate of COVID-19 patients were 12.29% (95% CI: 6.20-19.99; I2=98.29%). Conclusion: We assessed the prevalence SERO of the main clinical complications of COVID-19 and found that after respiratory complications, cardiac and renal complications are the most common clinical complications of COVID-19.

    In Silico Screening of Some Antiviral Phytochemicals as Drug Leads Against Covid-19

    Authors: Monjur Ahmed Laskar; Moriom Begam; Manabendra Dutta Choudhury

    doi:10.26434/chemrxiv.12478568.v1 Date: 2020-06-16 Source: ChemRxiv

    Background: COVID-19 caused by SARS-CoV-2 in December 2019 has become a pandemichazard to the community health. It is a respiratory difficulty causing fever HP, dry cough HP, fatigue HP,shortness of breath, muscle aches and some instances lead to pneumonia HP. Coronaviruses havelarge viral RNA Genomes and are single-stranded positive-sense RNA viruses. The nsp10/nsp16protein is an important target because it is essential for the virus to replicate, the papain-likeprotease (Nsp3), the main protease (Nsp5), the primary RNA-dependent RNA polymerase(Nsp12) are also attractive drug targets for this disease. The uses of phytochemicals astherapeutic agents have been increasing in recent years. Some antiviral phytochemicals weretaken based on literature survey for this study.Methods: ADME parameters and drug like nature of phytochemicals were screened usingSwissADME web tool. Three dimensional structures of targets are downloaded from ProteinData Bank and docked with phytochemicals & control by using software FlexX.Results: Morin shows significant results in ADME screening and Drug likeness predictionstudies, it shows stable bonding pattern with all four targets in compare to other phytochemicalsand control, shows least score in docking and forms maximum number of hydrogen bonds withthe active residues of the receptors.Conclusion: Based on present observation of docking results, ADME parameters and drug likenature, we suggest that morin may be a potent new drug candidate against Covid-19.Keywords: COVID-19, coronavirus, drug target, phytochemicals, Drug likeness, ADME,docking, morin

    Heterogeneity analysis of COVID - 19 clinical phenotype in Wuhan

    Authors: Qin Yin; Jiao Xie; Jixian Zhang; Zhen Fu; Wangcai Zhu; Wenguang Xia; Yihan Yu

    doi:10.21203/ Date: 2020-06-14 Source: ResearchSquare

    BackgroundSince the outbreak of coronavirus disease MESHD 2019 (COVID-19), some studies reported the clinical characteristics of COVID-19 patients in hospital. However, these studies did not investigate the clinical symptoms heterogeneity of COVID-19 patients in the outpatient. This study aimed to describe the heterogeneity of clinical characteristics of outpatient COVID-19 patients.MethodsCOVID-19 patients visiting the respiratory outpatient department of our hospital from January 1st to February 28st 2020 were retrospectively analyzed. Based on the complaints, the patients were classified into four groups including group A (patients without symptoms), group B (patients with fever HP fever MESHD), group C (patients with respiratory symptoms but without fever HP fever MESHD), and group D (patients with extra-respiratory symptoms but without fever HP fever MESHD). The difference of clinical characteristics, basic diseases, laboratory examination of outpatient, characteristics of chest CT imaging among all the groups were analyzed and compared.ResultsA total of 309 COVID-19 patients were included with 126 men and 183 women. The common symptoms included fatigue HP fatigue MESHD (59.87%, 95% CI: 54.17-65.38%), loss of appetite (51.13%, 95% CI: 45.41-56.83%), fever HP fever MESHD (50.81%, 95% CI: 45.09-56.51%), muscle soreness MESHD (41.42%, 95% CI:35.88-47.14%), and dry cough MESHD cough HP (35.28%, 95% CI:29.95-40.89%). The percentages of group A to group D were 2.91%, 50.81%, 18.12%, and 28.16%, respectively. The most common symptoms in Group D included fatigue HP fatigue MESHD, loss of appetite, muscle soreness MESHD. ConclusionThe heterogeneity of clinical symptoms for COVID-19 patients in the outpatient is significant. We should pay attention to patients without symptoms or those with only extra-respiratory symptoms, who are prone to missed diagnosis.

    Alarming Symptoms Leading To Severe COVID-19 Pneumonia HP: A Meta-Analysis

    Authors: Weiping Ji; Jing Zhang; Gautam Bishnu; Xudong Du; Xinxin Chen; Hui Xu; Xiaoling Guo; Zhenzhai Cai; Jun Zhang; Xian Shen

    doi:10.21203/ Date: 2020-06-14 Source: ResearchSquare

    Background: To identify alarming symptoms that could potentially lead to severe form of COVID-19 pneumonia HP pneumonia MESHD (i.e. novel coronavirus pneumonia MESHD pneumonia HP: NCP), a disease that is now having pandemic spread.Methods: Articles from PubMed, Embase, Cochrane database and Google up to 24 February 2020 were systematically reviewed. 18 publications that had documented cases of COVID-19 pneumonia HP pneumonia MESHD were identified. The relevant data were extracted, systematically reviewed and further evaluated using meta-analysis. We define severe COVID-19 pneumonia HP pneumonia MESHD as the disease status that requires admission to the intensive care unit (ICU) and respiratory/circulatory support, which is in align with the guideline from the World Health Organization (WHO).Results: 14 studies including 1,424 patients were considered eligible and analyzed. Symptoms such as fever HP fever MESHD (89.2%), cough HP (67.2%), fatigue HP fatigue MESHD (43.6%) were quite common; but dizziness MESHD, hemoptysis HP, abdominal pain HP abdominal pain MESHD and conjunctival congestion/ conjunctivitis HP conjunctivitis MESHD were relatively rare. The incidence of dyspnea HP dyspnea MESHD was significantly higher in patients with severe than non-severe COVID-19 pneumonia HP pneumonia MESHD (42.7% vs.16.3%, p<0.0001). Similarly, fever HP fever MESHD and diarrhea HP diarrhea MESHD were also drastically more common in patients with severe form (p=0.0374 and 0.0267). Further meta-analysis using three high-quality China-based studies confirmed such findings and showed that dyspnea HP dyspnea MESHD, fever HP fever MESHD and diarrhea HP diarrhea MESHD were 3.53 (OR: 3.53, 95%CI: 1.95-6.38), 1.70 (OR: 1.70, 95%CI: 1.01-2.87), and 1.80 (OR: 1.80, 95%CI: 1.06-3.03) folds higher respectively in patients with severe COVID-19 pneumonia HP pneumonia MESHD.Conclusion: Dyspnea HP Dyspnea MESHD, fever HP and diarrhea HP diarrhea MESHD are significantly more prevalent in patients with severe COVID-19 pneumonia HP pneumonia MESHD, suggesting they are alarming symptoms that warrant close attention and timely management.

    "Analysis of the Primary Presenting Symptoms and Hematological Findings of COVID19 Patients in Bangladesh"

    Authors: Abu Taiub Mohammed Mohiuddin Chowdhury; Md Rezaul Karim; H.M.Hamidullah Mehedi; Mohammad Shahbaz; Md Wazed Chowdhury; Dan Guo; Shuixiang He

    doi:10.21203/ Date: 2020-06-12 Source: ResearchSquare

    Background:SARS-Cov-2 infection MESHD or COVID-19 is a global pandemic. From the time of identification to till, multiple clinical symptoms and parameters have been identified by the researchers of various countries and regions regarding the diagnosis and presentations of COVID19 disease. In this manuscript, we investigated the primary symptoms and basic hematological presentations of SARS-CoV-2 infection MESHD among the Bangladeshi patients. Methodology: We have collected the disease history of mild to moderate degree of COVID19 patients; hematological MESHD and biochemical on admission reports of moderate degree COVID19 patients.  All of them were tested positive for SARS-CoV-2 by RT PCR in different institutes in Bangladesh. Results: According to this study though COVID19 patients in Bangladesh commonly presented with fever HP fever MESHD, cough HP cough MESHD, fatigue HP fatigue MESHD, shortness of breath MESHD, and sore throat, but symptoms like myalgia HP myalgia MESHD, diarrhea HP diarrhea MESHD, skin rash HP skin rash MESHD, headache HP headache MESHD, Abdominal pain HP Abdominal pain MESHD/cramp, nausea, vomiting HP nausea, vomiting MESHD vomiting MESHD, restlessness HP, and a higher temperature of >1000F have a greater presentation rate and more frequent than other published studies. CRP and Prothrombin time was found to increase in all the patients. Serum SERO ferritin, ESR, SGPT, and D-Dimer were found increased among 53.85%, 80.43, 44%, and 25% patients respectively. 17.39% of the patients had leucocytosis and neutrophilia HP. 28.26% of patients presented with lymphocytopenia MESHD. 62.52% of patients had mild erythrocytopenia. Conclusion: Despite some similarities, our study has evaluated a different expression in presenting symptoms in the case of COVID19 patients in Bangladesh. CRP, Prothrombin time, serum SERO ferritin, ESR, SGPT, D-Dimer, erythrocytopenia, and lymphocytopenia MESHD can be initial diagnostic hematological findings and assessments for prognosis COVID19 disease. Also, Gender TRANS variation has a different scenario of clinical and laboratory appearance in this region.

    SARS-CoV-2 Serology Results in the First COVID-19 Case in California: A Case Report and Recommendations for Serology Testing and Interpretation

    Authors: Richard B. Lanman, MD; Todd H. Lanman

    doi:10.21203/ Date: 2020-06-12 Source: ResearchSquare

    Background: As countries in COVID-19 pandemic lockdown begin relaxation of shelter-in-place mitigation strategies, the role of serology testing escalates in importance. However, there are no clear guidelines as to when to use qualitative rapid diagnostic serology tests (RDTs) vs. SARS-CoV-2 viral RNA load (PCR) tests as an aid in acute diagnosis of patients presenting with flu-like symptoms, nor how to interpret serology test results in asymptomatic TRANS individuals or those with atypical COVID-19 symptomatology. Here we describe, in the context of the likely first case of COVID-19 in California, with an atypical presentation and not tested acutely, who nearly 3 months later was found to be IgM- and IgG+ positive for SARS-CoV-2 antibodies SERO, highlighting the role of RDT- based serology testing SERO and interpretation in retrospective diagnosis.Case Presentation: A 62-year-old male TRANS practicing neurosurgeon had onset of flu-like symptoms on January 20 with fatigue HP fatigue MESHD, slight cough HP only on deep inspiration, intermittent pleuritic chest pain MESHD chest pain HP unrelated to exertion, dyspnea HP dyspnea MESHD, and night sweats HP but without fever HP fever MESHD, sore throat or rhinorrhea HP rhinorrhea MESHD. He had recently traveled TRANS abroad but not to China. CT scan revealed right lower lobe infiltrate and effusion. Because of atypical symptoms, and low prevalence SERO of COVID-19 in January, community acquired pneumonia HP pneumonia MESHD was diagnosed and one week of doxycycline was prescribed without relief, followed by a second week of azithromycin with symptom remission. Three months later the physician-patient (author THL), tested positive for SARS-CoV-2 antibodies SERO by a serology point-of-care rapid diagnostic test (RDT).Conclusions: Serology testing may be an aid in acute diagnosis of COVID-19, especially in patients with atypical presentations, as well as in assessment of asymptomatic TRANS higher-risk persons such as healthcare workers for prior infection MESHD. Recommendations for serology testing and interpretation are explicated.


    Authors: Mobina Fathi; Kimia Vakili; Fatemeh Sayehmiri; Ashraf Mohamadkhani; Mohammadreza Hajiesmaeili; Mostafa Rezaei-Tavirani; Owrang Eilami

    doi:10.1101/2020.06.11.20128835 Date: 2020-06-12 Source: medRxiv

    Abstract: Background and Aim: With the increase in the number of COVID-19 infections, global health is facing insufficient sources; this study aimed to provide additional data regarding the clinical characteristics of patients diagnosed with COVID-19 and in particular to analyze the factors associated with disease severity, unimprovement and mortality. Methods: 82 studies were included in the present meta-analysis that all of them have been published before May 1, 2020 and were found by searching through the databases Scopus and MEDLINE. The selected papers were studied and analyzed by employing the version 14 of stata software. It should be noted that, we employed I2 statistics for testing and verifying heterogeneity. Results: 82 papers were finally chosen for this meta- analysis, including 74855 infected MESHD patients (35673 men, 31140 women). The mean age TRANS of the patients was 56.49. The results indicate the prevalence SERO of fever HP fever MESHD 79.84 (95% CI: 75.22-84.13), cough HP 59.53 (95% CI: 55.35-63.65), fatigue HP fatigue MESHD or myalgia HP myalgia MESHD 33.46 (95% CI: 28.68-38.40), dyspnea HP dyspnea MESHD 31.48 (95% CI: 25.75-37.49) and diarrhea HP diarrhea MESHD 10.71 (95% CI: 8.20-13.49). The prevalence SERO of the most common comorbidities were hypertension HP hypertension MESHD 25.10 (95% CI: 19.91-30.64), diabetes MESHD 13.48 (95% CI: 10.61-16.62), cardiovascular diseases MESHD 8.94 (95% CI: 6.99-11.10), and chronic kidney disease HP chronic kidney disease MESHD 3.27 (95% CI: 2.22-4.47). Conclusion: The results of this study are seriously needed to effectively monitor the health of people with comorbidities ( hypertension HP hypertension MESHD, diabetes MESHD, cardiovascular and cerebrovascular disease MESHD, coronary heart disease MESHD disease, and chronic kidney HP chronic kidney disease MESHD) to prevent the development of COVID-19 infection MESHD.

    Management and Outcomes of patients on maintenance dialysis during the COVID-19 pandemic: a report from Geneva, Switzerland

    Authors: Ido Zamberg; Thomas Mavrakanas; Thomas Ernandez; Vincent Bourquin; Michael Zellweger; Nicola Marangon; Francoise Raimbault; Rebecca Winzeler; Anne Iten; Pierre-Yves Martin; Patrick Saudan

    doi:10.21203/ Date: 2020-06-12 Source: ResearchSquare

    Background Patients on maintenance hemodialysis are at high risk for serious complications from COVID-19 infection MESHD including death. We present an overview of the local experience with dialysis units management and reorganization, local epidemiology and outcomes during the COVID-19 outbreak in Geneva, Switzerland.Methods All SARS-CoV-2 positive outpatients on maintenance dialysis were transferred from their usual dialysis facility to the Geneva University Hospitals dialysis unit to avoid creation of new clusters of transmission TRANS. Within this unit, appropriate mitigation measures were enforced as suggested by the institutional team for prevention and control of infectious diseases MESHD.Results From February 25 to May 18, 2020, 19 of 246 patients on maintenance dialysis were tested positive for SARS-CoV-2, representing an incidence rate of 97.6 cases per 100,000 person-days. Eighteen patients were on maintenance hemodialysis and one on peritoneal dialysis. Twelve of these infections were detected during the first two weeks after mitigation strategies were enforced. Most common symptoms were fever HP fever MESHD (89%), cough HP (84%) and fatigue HP fatigue MESHD (68%). Two patients required orotracheal intubation. Six patients on maintenance hemodialysis who had previously tested positive for SARS-CoV-2, all of them male TRANS, died (32%). Five deaths were COVID-19 related and one death was due to dialysis withdrawal at the patient’s request. Conclusion Strict mitigation measures seemed to be effective to control infection MESHD spread among patients on maintenance dialysis. COVID-19 infection MESHD is associated with a high fatality rate. Large scale epidemiological studies are needed to assess the efficacy of preventive measures in decreasing infection MESHD and mortality rate within the dialysis population.

    COVID-19 patients with hypertension HP hypertension MESHD under potential risk of worsened organ injuries

    Authors: Fei Xia; Mingwei Zhang; Bo Cui; Wei An; Min Chen; Ping Yang; Tao Qin; Xiaoyang Zhou; Yaling Liao; Xin Xu; Shiguo Liu; Kuangyu Li; Qin Zhou; Keke Wang; Guangxu Hu; Ming Du; Songrui Chen; Jianjun Zhang; Yafang Zhang; Wei Wei; Ming Xiang

    doi:10.21203/ Date: 2020-06-11 Source: ResearchSquare

    COVID -19 has rapidly spread from Wuhan to worldwide, and now has become a global health concern. Hypertension HP Hypertension MESHD is the most common chronic illness in COVID-19, while the influence on those patients have not been well described. In this retrospective study, 82 confirmed patients with COVID-19 were enrolled, with epidemiological, demographic, clinical, laboratory, radiological, and therapies data analyzed and compared between COVID-19 patients with (29 cases) or without (53 cases) hypertension HP hypertension MESHD. Of all 82 patients with COVID-19, the median age TRANS of all patients was 60.5 years, including 49 females TRANS (59.8%) and 33 (40.2%) males TRANS. Hypertension HP Hypertension MESHD (31[28.2%]) was the most chronic illness, followed by diabetes MESHD (16 [19.5%]) and cardiovascular disease MESHD (15 [18.3%]). Common symptoms included fatigue HP (55[67.1%]), dry cough HP (46 [56.1%]) and fever HP (≥37.3℃ (46 [56.1%]). The median time from illness onset to positive outcomes of RT-PCR analysis were 13.0 days, ranging from 3-25 days. In hypertension HP group, 6 (20.7%) patients died compared to 5 (9.4%) died in non- hypertension HP group. More hypertension HP patients with COVID-19 (8 [27.6%]) had at least one coexisting disease than those of non- hypertension HP patients (2 [3.8%]) (P=0.002). Compared with non- hypertension HP patients, higher levels of neutrophil counts, serum SERO amyloid A, C-reactive protein, and NT-proBNP were observed in hypertension HP group, whereas levels of lymphocyte count and eGFR were decreased. Dynamic observations displayed more significant and worsened outcomes in hypertension HP group after hospital admission. COVID-19 patients with hypertension HP take more risks of severe inflammatory reactions, worsened internal organ injuries, and deteriorated progress. 

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MeSH Disease
Human Phenotype

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