Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

gender (1)


Seroprevalence

There are no seroprevalence terms in the subcorpus

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    The Molecular Basis of Gender TRANS Variations in Mortality Rates Associated with the Novel Coronavirus (COVID-19) Outbreak

    Authors: Ibrahim Y. Hachim; Mahmood Y. Hachim; Iman Mamdouh Talaat; Vanessa M. López-Ozuna; Narjes Saheb Sharif-Askari; Rabih Halwani; Qutayba Hamid

    id:10.20944/preprints202005.0364.v1 Date: 2020-05-23 Source: Preprints.org

    Since the outbreak of the novel coronavirus disease MESHD (COVID-19) at the end of 2019, the clinical presentation of the disease showed a great heterogeneity with a diverse impact between different subpopulations. Emerging evidence from different parts of the world showed significantly poor outcome among males TRANS compared to female TRANS patients. A better understanding of the molecular mechanisms behind this difference might be a fundamental step for a more effective and targeted response to the outbreak. For that reason, here we try to investigate the molecular basis of the gender TRANS variations in mortality rates related to COVID-19 infection MESHD. To achieve this, we used our in-house pipeline to process publicly available lung transcriptomic data from 141 females TRANS compared to 286 males TRANS. After excluding Y specific genes, our results showed a shortlist of 73 genes that are differentially expressed between the two groups. Our results showed downregulation of a group of genes that are involved in the regulation of hydrolase activity including (AGTR1, CHM MESHD, DDX3X, FGFR3, SFRP2, and NLRP2), which is also believed to be essential for lung immune response and antimicrobial activity in the lung tissues in males TRANS compared to females TRANS. In contrast, our results showed an upregulation of angiotensin II receptor type 1 (AGTR1), a member of the renin-angiotensin system (RAS) that plays a role in angiotensin-converting enzyme 2 (ACE2) activity modulation. Interestingly, recent reports and experimental animal models highlight an important role of this receptor in SARS-Coronavirus lung damage MESHD as well as pulmonary edema HP pulmonary edema MESHD, suggesting a possible role of its blockers like losartan and olmesartan as potential therapeutic options for COVID-19 infection MESHD. Finally, our results also showed a differential expression of different genes that are involved in the immune response including the NLRP2 and PTGDR2, further supporting the notion of the sex-based immunological differences. Taken together, our results provide an initial evidence of the molecular mechanisms that might be involved in the differential outcomes observed between both genders TRANS during the COVID-19 outbreak. This might be essential for the discovery of new targets and more precise therapeutic options to treat COVID-19 patients from different clinical and epidemiological characteristics with the aim of improving their outcome.

    Supramolecular Organization Predicts Protein Nanoparticle Delivery to Neutrophils for Acute Lung Inflammation MESHD Diagnosis and Treatment

    Authors: Jacob W Myerson; Priyal N Patel; Nahal Habibi; Landis R Walsh; Yi-Wei Lee; David C Luther; Laura T Ferguson; Michael H Zaleski; Marco E Zamora; Oscar A. Marcos-Contreras; Patrick M Glassman; Ian Johnston; Elizabeth D Hood; Tea Shuvaeva; Jason V Gregory; Raisa Y Kiseleva; Jia Nong; Kathryn M Rubey; Colin F Greineder; Samir Mitragotri; George S Worthen; Vincent M Rotello; Joerg Lahann; Vladimir R Muzykantov; Jacob S Brenner

    doi:10.1101/2020.04.15.037564 Date: 2020-04-18 Source: bioRxiv

    Acute lung inflammation MESHD has severe morbidity, as seen in COVID-19 patients. Lung inflammation MESHD is accompanied or led by massive accumulation of neutrophils in pulmonary capillaries ("margination"). We sought to identify nanostructural properties that predispose nanoparticles to accumulate in pulmonary marginated neutrophils, and therefore to target severely inflamed lungs. We designed a library of nanoparticles and conducted an in vivo screen of biodistributions in naive mice and mice treated with lipopolysaccharides. We found that supramolecular organization of protein in nanoparticles predicts uptake in inflamed lungs. Specifically, nanoparticles with agglutinated protein (NAPs) efficiently home to pulmonary neutrophils, while protein nanoparticles with symmetric structure (e.g. viral capsids) are ignored by pulmonary neutrophils. We validated this finding by engineering protein-conjugated liposomes that recapitulate NAP targeting to neutrophils in inflamed lungs. We show that NAPs can diagnose acute lung injury MESHD in SPECT imaging and that NAP-like liposomes can mitigate neutrophil extravasation and pulmonary edema HP pulmonary edema MESHD arising in lung inflammation MESHD. Finally, we demonstrate that ischemic MESHD ex vivo human lungs selectively take up NAPs, illustrating translational potential. This work demonstrates that structure-dependent interactions with neutrophils can dramatically alter the biodistribution of nanoparticles, and NAPs have significant potential in detecting and treating respiratory conditions arising from injury or infections MESHD.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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