Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Modeling COVID-19 Transmission TRANS in Africa: Country-wise Projections of Total and Severe Infections HP Under Different Lockdown Scenarios

    Authors: Isabel Frost; Jessica Craig; Gilbert Osena; Stephanie Hauck; Erta Kalanxhi; Emily Schueller; Oliver Gatalo; Yupeng Yany; Katie Tseng; Gary Lin; Eili Klein

    doi:10.1101/2020.09.04.20188102 Date: 2020-09-07 Source: medRxiv

    Objectives As of August 24th 2020, there have been 1,084,904 confirmed cases TRANS of SARS-CoV-2 and 24,683 deaths across the African continent. Despite relatively lower numbers of cases initially, many African countries are now experiencing an exponential increase in case numbers. Estimates of the progression of disease and potential impact of different interventions are needed to inform policy making decisions. Herein, we model the possible trajectory of SARS-CoV-2 in 52 African countries under different intervention scenarios. Design We developed a compartmental model of SARS-CoV-2 transmission TRANS to estimate the COVID-19 case burden for all African countries while considering four scenarios: no intervention, moderate lockdown, hard lockdown, and hard lockdown with continued restrictions once lockdown is lifted. We further analyzed the potential impact of COVID-19 on vulnerable populations affected by HIV MESHD/ AIDS MESHD and TB. Results In the absence of an intervention, the most populous countries had the highest peaks in active projected number of infections MESHD with Nigeria having an estimated 645,081 severe infections HP infections MESHD. The scenario with a hard lockdown and continued post-lockdown interventions to reduce transmission TRANS was the most efficacious strategy for delaying the time to the peak and reducing the number of cases. In South Africa projected peak severe infections HP increase from 162,977 to 203,261, when vulnerable populations with HIV MESHD/ AIDS MESHD and TB are included in the analysis. Conclusion The COVID-19 pandemic is rapidly spreading across the African continent. Estimates of the potential impact of interventions and burden of disease are essential for policy makers to make evidence-based decisions on the distribution of limited resources and to balance the economic costs of interventions with the potential for saving lives.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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