Corpus overview


Overview

MeSH Disease

Human Phenotype

There are no HP terms in the subcorpus


Transmission

There are no transmission terms in the subcorpus


Seroprevalence

antibody (1)

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    AI aided design of epitope-based vaccine for the induction of cellular immune responses against SARS-CoV-2

    Authors: Giovanni Mazzocco; Iga Niemiec; Alexander Myronov; Piotr Skoczylas; Jan Kaczmarczyk; Anna Sanecka-Duin; Katarzyna Gruba; Paulina Król; Michał Drwal; Marian Szczepanik; Krzysztof Pyrć; Piotr Stępniak; Alex Espinosa; Wesley Wu; Joshua Batson; David Dynerman; - CLIAHUB Consortium; Debra A Wadford; Andreas Puschnik; Norma Neff; Vida Ahyong; Steve Miller; Patrick Ayscue; Cristina M Tato; Simon Paul; Amy Kistler; Joseph L DeRisi; Emily Dawn Crawford; Toni Vagt; Gabriel Sigrist; Marcel Straumann; Karl Proba; Niina Veitonmaki; Keith M. Dawson; Christof Zitt; Jennifer Mayor; Sarah Ryter; Heyrhyoung Lyoo; Chunyan Wang; Wentao Li; Ieva Drulyte; H. Kaspar Binz; Leon de Waal; Koert J. Stittelaar; Seth Lewis; Daniel Steiner; Frank J.M. van Kuppeveld; Olivier Engler; Berend-Jan Bosch; Michael T. Stumpp; Patrick Amstutz

    doi:10.1101/2020.08.26.267997 Date: 2020-08-26 Source: bioRxiv

    The heavy burden imposed by the COVID-19 pandemic on our society triggered the race towards the development of therapies or preventive strategies. Among these, antibodies SERO and vaccines are particularly attractive because of their high specificity, low probability of drug-drug interaction, and potentially long-standing protective effects. While the threat at hand justifies the pace of research, the implementation of therapeutic strategies cannot be exempted from safety considerations. There are several potential adverse events reported after the vaccination or antibody SERO therapy, but two are of utmost importance: antibody SERO-dependent enhancement (ADE) and cytokine storm syndrome (CSS). On the other hand, the depletion or exhaustion of T-cells has been reported to be associated with worse prognosis in COVID-19 patients. This observation suggests a potential role of vaccines eliciting cellular immunity, which might simultaneously limit the risk of ADE and CSS. Such risk was proposed to be associated with FcR-induced activation of proinflammatory macrophages (M1) by Fu et al. 2020 and Iwasaki et al. 2020. All aspects of the newly developed vaccine (including the route of administration, delivery system, and adjuvant selection) may affect its effectiveness and safety. In this work we use a novel in silico approach (based on AI and bioinformatics methods) developed to support the design of epitope-based vaccines. We evaluated the capabilities of our method for predicting the immunogenicity of epitopes. Next, the results of our approach were compared with other vaccine-design strategies reported in the literature. The risk of immuno-toxicity MESHD was also assessed. The analysis of epitope conservation among other Coronaviridae was carried out in order to facilitate the selection of peptides shared across different SARS-CoV-2 strains and which might be conserved in emerging zootic coronavirus strains. Finally, the potential applicability of the selected epitopes for the development of a vaccine eliciting cellular immunity for COVID-19 was discussed, highlighting the benefits and challenges of such an approach.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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