Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Effects of COVID-19 on the Gut and the Liver - A Case Series of 711 Patients in New York City

    Authors: Sher Nazir Baig, MD; Fuad Abaleka, MD; Stephanie Herrera, MD; Mina Daniel, MD; Bisrat Nigusse, MD; Thu M Vu, MD; Tigist Gemechu, MD; George Abdelsayed, MD, FACG

    doi:10.21203/rs.3.rs-55080/v1 Date: 2020-08-06 Source: ResearchSquare

    Background As the COVID-19 epidemic is wreaking havoc with a staggering number of infections MESHD and fatalities worldwide, digestive symptoms are increasingly coming to the limelight. However, the data on the extent of gut and liver involvement has been variable and somewhat conflicting.Methods We identified 711 adults TRANS who had tested positive for COVID-19 at Richmond University Medical Center in New York between March 13 and May 13, 2020. We analyzed their clinical and laboratory data from electronic medical records.Results The average age TRANS of the patients was 60.5 years; 55% were men. 27.1% reported a gastrointestinal ( GI MESHD) symptom and 56.9% had at least one abnormal liver enzyme. The most common was diarrhea HP diarrhea MESHD with a frequency of 17.3% followed by nausea HP nausea MESHD 16.2% and vomiting HP vomiting MESHD/ anorexia HP anorexia MESHD 13.7%. Abdominal pain HP Abdominal pain MESHD 5.6%, dysgeusia MESHD 3.2%, and GI bleeding MESHD 2.2% was the least common. Symptoms were mostly mild and lasted 3-5 days. The liver function was deranged in more than half of the patients. AST alone was elevated in 16.6%, both AST/ALT 15.7%, alkaline phosphatase 23%, and bilirubin 10%. Potential confounders were rare but included preexisting liver disease MESHD and hepatotoxic MESHD medications. Prothrombin time (PT) was mildly elevated in 13.4%. The lipase was elevated in 2.4% without upper abdominal pain HP abdominal pain MESHD. In 75%-90% of cases, liver test abnormalities MESHD were mild (1.5-3 x normal). Overall, 86.6% of patients were admitted primarily with respiratory failure HP respiratory failure MESHD and 28.5% died of their illness.Conclusions 27% of COVID-19 patients experienced a digestive disturbance and >55% showed a predominantly mild degree of liver dysfunction MESHD and cholestasis HP cholestasis MESHD.

    Maternal and fetal effects of covid-19 virus on a complicated triplet pregnancy. A case-report

    Authors: Maryam Rabiei; Tahereh Soori; Amene Abiri; Arshia Shizarpour; Zohreh Farsi; Reihaneh Pirjani

    doi:10.21203/rs.3.rs-25864/v1 Date: 2020-04-28 Source: ResearchSquare

    Background:  COVID-19 virus it is going to be pandemic all around the world. There is still limited scientific evidence on the manifestations and potential impact of this virus on pregnancy.Case presentation She was a 38 year-old triplet pregnant with a history of primary infertility HP infertility MESHD and had become pregnant by induction ovulation and a history of hypothyroidism HP hypothyroidism MESHD and also a history of gestational diabetes MESHD. She was hospitalized at 29 weeks and 2 days gestational age TRANS due to elevated liver enzymes MESHD and finally based on a probable diagnosis of gestational cholestasis MESHD cholestasis HP, she was treated with ursodeoxycholic acid. On the first day after hospitalization, a sonography was performed in which biophysical scores and amniotic fluid were found normal in all three fetuses with normal Doppler findings in two fetuses and increased umbilical artery resistance (PI>95%) in one fetus. Four days after hospitalization, she developed fever HP fever MESHD, cough HP cough MESHD and myalgia HP myalgia MESHD and her covid-19 test was positive. After maternal infection MESHD with the virus, exacerbated placental insufficiency MESHD occurred in two of the fetuses so that absent umbilical artery end diastolic flow occurred rapidly in two fetuses and finally, six days later, she underwent cesarean section due to rapid exacerbated placental insufficiency MESHD and declined biophysical score in two of fetuses. Covid-19 test of nasopharyngeal swabs was negative for first and third babies and positive for second baby .The first and third babies died 3 and 13 days after birth respectively duo to collapsed white lung and sepsis HP sepsis MESHD. The second baby was discharged with a good general condition. The mother was discharged three days after cesarean section. She had no fever HP fever MESHD at discharge time and also she was in good general condition.Conclusions: It was a complicated triplet pregnancy, in which, after maternal infection MESHD with the Covid-19 virus, exacerbated placental insufficiency MESHD occurred in two of the fetuses, and another fetus had positive covid-19 virus test after birth. It sounds wise that in pregnancy infected by corona virus, in addition to managing the mother, special attention should also be given to the possibility of acute placental insufficiently MESHD and subsequent fetal hypoxia MESHD and also probability of vertical transmission TRANS.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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MeSH Disease
Human Phenotype
Transmission
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