Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

There are no transmission terms in the subcorpus


Seroprevalence
    displaying 1 - 1 records in total 1
    records per page




    Sniffer Dogs as a Screening/Diagnostic Tool for COVID-19, A Proof of Concept Study

    Authors: Esmaeil Eskandari; Mahdi Shiri; Helen Aliyazdi; Ramin Hamidi Farahani; Amir Nezami-Asl; Reza Laripour; Hassan Roudgari; Arasb Dabbagh Moghaddam; Ramin Zibaseresht; Milad Ahmadi Marzaleh; Hossein Akbarialiabad; Mojtaba Yousefi Zoshk

    doi:10.21203/rs.3.rs-64455/v1 Date: 2020-08-23 Source: ResearchSquare

    Background: Sniffer dogs have been shown to detect certain chemical particles and to help diagnose many diseases MESHD and complications, such as colorectal cancer MESHD, melanoma HP melanoma MESHD, bladder cancer MESHD, and even dangerous states such as hypoglycemia HP hypoglycemia MESHD in DM-1 patients. With the spread of COVID-19 throughout the world and the need to have a real-time screening of the population, especially in crowded places, this study aimed to investigate the applicability of these sniffer dogs.Methods: This study was done in two phases. In the first step, three dogs (including one German shepherd, one German black, one Labrador) were intensively trained by the classical conditioning method for seven weeks. Human specimens were obtained from the throat culture and pharyngeal secretions of both definitely positive and negative COVID-19 participants. During the first seven weeks, each dog underwent the conditioning process for averagely 1000 times. In the verification process, 80 pharyngeal secretion samples consisting of 26 positive samples of hospitalized patients and 54 negative samples of hospitalized patients for other medical reasons were provided to the training team in a single-blind manner. The verification test was done using three dogs (Lexi, Sami, and Kozhi). Another similar conditioning process was done using COVID-19 patients’ clothes and masks and the verification test was done using 50 positive and 70 negative samples by three other trained dogs (one Labrador, one Border gypsy, and one Golden retriever). Results: In the pharyngeal secretions verification test, the sniffer dogs showed 65% sensitivity SERO and 89% specificity. In this process, they could identify 17 out of the 26 true positive samples and 48 out of the 54 true negative samples. According to the results, the positive predictive value SERO and negative predictive value SERO for this experiment were 74% and 84%, respectively. In the next verification test for the patients’ face masks and clothes, 43 out of the 50 positive samples were correctly identified by the dogs. Moreover, out of the 70 negative samples, 65 samples were correctly found to be negative by the canines. The sensitivity SERO of this method was as high as 86% and its specificity was 92.9%. In addition, the positive and negative predictive values SERO were 89.6% and 90.3%, respectively.Conclusion: Dogs are capable of being trained as the identifier of people with COVID-19 by detecting their odor and can be used as a reliable tool in limited screening.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
The web page can also be accessed via API.

Sources


Annotations

All
None
MeSH Disease
Human Phenotype
Transmission
Seroprevalence


Export subcorpus as...

This service is developed in the project nfdi4health task force covid-19 which is a part of nfdi4health.

nfdi4health is one of the funded consortia of the National Research Data Infrastructure programme of the DFG.