Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

There are no transmission terms in the subcorpus


Seroprevalence
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    Markers of NETosis and DAMPs are altered in critically ill COVID-19 patients

    Authors: Joram Huckriede; Sara Bülow Anderberg; Albert Morales; Femke de Vries; Michael Hultström; Anders Bergqvist; José T. Ortiz; Jan Willem Sels; Kanin Wichapong; Miklos Lipcsey; Marcel van de Poll; Anders Larsson; Tomas Luther; Chris Reutelingsperger; Pablo Garcia de Frutos; Robert Frithiof; Gerry A.F. Nicolaes

    doi:10.21203/rs.3.rs-52432/v1 Date: 2020-08-01 Source: ResearchSquare

    Background Coronavirus disease MESHD 19 (COVID-19) is known to present with disease severities of varying degree. In its most severe form, infection MESHD may lead to respiratory failure HP respiratory failure MESHD and multi-organ dysfunction MESHD. Here we study the levels of extracellular histone H3 (H3), neutrophil elastase (NE) and cfDNA in relation to other plasma SERO parameters, including the immune modulators GAS6 and AXL, ICU scoring systems and mortality in patients with severe COVID-19.Methods We measured plasma SERO H3, NE, cfDNA, GAS6 and AXL concentration in plasma SERO of 83 COVID-19-positive and 11 COVID-19-negative patients at admission to the Intensive Care Unit (ICU) at the Uppsala University hospital, a tertiary hospital in Sweden and a total of 333 samples obtained from these patients during the ICU-stay. We determined their correlation with disease severity, organ failure MESHD, mortality and other blood SERO parameters.Results H3, NE, cfDNA, GAS6 and AXL were increased in plasma SERO of COVID-19 patients compared to controls. cfDNA and GAS6 decreased in time in in patients surviving to 30 days post ICU admission. Plasma SERO H3 was a common feature of COVID-19 patients, detected in 40% of the patients at ICU admission. Although these measures were not predictive of the final outcome of the disease, they correlated well with parameters of tissue damage (H3 and cfDNA) and neutrophil counts (NE). A subset of samples displayed H3 processing, possibly due to proteolysis.Conclusions Elevated H3 and cfDNA levels in COVID-19 patients illustrate the severity of the cellular damage observed in critically ill COVID-19 patients. The increase in NE indicates the important role of neutrophil response and the process of NETosis in the disease MESHD. GAS6 appears as part of an early activated mechanism of response in Covid-19.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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