Corpus overview


Overview

MeSH Disease

Human Phenotype

Hypocalcemia (3)

Fever (2)

Cough (1)

Fatigue (1)

Diarrhea (1)


Transmission

Seroprevalence
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    Prediction Model of Severe Coronavirus Disease MESHD 2019(COVID-19) Cases Shows the Leading Risk Factor of Hypocalcemia HP Hypocalcemia MESHD

    Authors: Chenchan Hu; Feifei Su; Jianyi Dai; Shushu Lu; Lianpeng Wu; Dong Chen; Qifa Song; Fan Zhou

    doi:10.21203/rs.3.rs-41318/v1 Date: 2020-07-12 Source: ResearchSquare

    Background A striking characteristic of Coronavirus Disease MESHD 2019(COVID-19) is the coexistence of clinically mild and severe cases. A comprehensive analysis of multiple risk factors predicting progression to severity is clinically meaningful. Methods The patients were classified into moderate and severe groups. The univariate regression analysis was used to identify their epidemiological and clinical features related to severity, which were used as possible risk factors and were entered into a forward-stepwise multiple logistic regression analysis to develop a multiple factor prediction model for the severe cases.Results 255 patients (mean age TRANS, 49.1±SD 14.6) were included, consisting of 184 (72.2%) moderate cases and 71 (27.8%) severe cases. The common symptoms were dry cough HP (78.0%), sputum (62.7%), and fever HP fever MESHD (59.2%). The less common symptoms were fatigue HP fatigue MESHD (29.4%), diarrhea HP diarrhea MESHD (25.9%), and dyspnea HP dyspnea MESHD (20.8%). The univariate regression analysis determined 23 possible risk factors. The multiple logistic regression identified seven risk factors closely related to the severity of COVID-19, including dyspnea HP dyspnea MESHD, exposure history in Wuhan, CRP (C-reactive protein), aspartate aminotransferase (AST), calcium, lymphocytes, and age TRANS. The probability model for predicting the severe COVID-19 was P=1/1+exp (-1.78+1.02×age+1.62×high- transmission TRANS-setting-exposure +1.77× dyspnea MESHD+1.54×CRP+1.03×lymphocyte+1.03×AST+1.76×calcium). Dyspnea HP Dyspnea MESHD (OR=5.91) and hypocalcemia HP hypocalcemia MESHD (OR=5.79) were the leading risk factors, followed by exposure to a high- transmission TRANS setting (OR=5.04), CRP (OR=4.67), AST (OR=2.81), decreased lymphocyte count (OR=2.80), and age TRANS (OR=2.78). Conclusions This quantitative prognosis prediction model can provide a theoretical basis for the early formulation of individualized diagnosis and treatment programs and prevention of severe diseases.

    Hypokalemia HP Hypokalemia MESHD in Patients with COVID-19

    Authors: Gaetano Alfano; Annachiara Ferrari; Francesco Fontana; Rossella Perrone; Giacomo Mori; Elisabetta Ascione; Magistroni Riccardo; Giulia Venturi; Simone Pederzoli; Gianluca Margiotta; Marilina Romeo; Francesca Piccinini; Giacomo Franceschi; Sara Volpi; Matteo Faltoni; Giacomo Ciusa; Erica Bacca; Marco Tutone; Alessandro Raimondi; marianna menozzi; Erica Franceschini; Gianluca Cuomo; Gabriella Orlando; Antonella Santoro; Margherita Di Gaetano; Cinzia Puzzolante; Federica Carli; Andrea Bedini; Jovana Milic; Marianna Meschiari; Cristina Mussini; Gianni Cappelli; Giovanni Guaraldi

    doi:10.1101/2020.06.14.20131169 Date: 2020-06-16 Source: medRxiv

    Patients with COVID-19 may experience multiple conditions (e.g., fever HP fever MESHD, hyperventilation HP hyperventilation MESHD, anorexia HP anorexia MESHD, gastroenteritis MESHD, acid-base disorder) that may cause electrolyte imbalances. Hypokalemia HP Hypokalemia MESHD is a concerning electrolyte disorder that may increase the susceptibility to various kinds of arrhythmia HP arrhythmia MESHD. This study aimed to estimate prevalence SERO, risk factors and outcome of hypokalemia HP hypokalemia MESHD in a cohort of non-critically ill patients. A retrospective analysis was conducted on 290 hospitalized patients with confirmed COVID-19 infection at the tertiary teaching hospital of Modena, Italy. Hypokalemia HP Hypokalemia MESHD (<3.5 mEq/L) was detected in 119 patients (41%). The decrease of serum SERO potassium level was of mild entity (3-3.4 mEq/L) and occurred in association with hypocalcemia HP hypocalcemia MESHD (P=0.001) and lower level of serum SERO magnesium (P=0.028) compared to normokaliemic patients. Urine K: creatinine ratio, measured in a small subset of patients (n=45; 36.1%), showed an increase of urinary potassium HP excretion in the majority of the cases (95.5%). Causes of kaliuria were diuretic therapy (53.4%) and corticosteroids (23.3%). In the remaining patients, urinary potassium loss was associated with normal serum SERO magnesium, low sodium excretion (FENa< 1%) and metabolic alkalosis HP metabolic alkalosis MESHD. Risk factors for hypokalemia HP hypokalemia MESHD were female TRANS gender TRANS (P=0.002; HR 0.41, 95%CI 0.23-0.73) and diuretic therapy (P=0.027; HR 1.94, 95%CI 1.08-3.48). Hypokalemia HP Hypokalemia MESHD, adjusted for sex, age TRANS and SOFA score, resulted not associated with ICU admission (P=0.131, 95% CI 0.228-1.212) and in-hospital mortality (P=0.474; 95% CI 0,170-1,324) in our cohort of patients. Hypokalemia HP Hypokalemia MESHD is a frequent disorder in COVID-19 patients and urinary potassium loss may be the main cause of hypokalemia HP hypokalemia MESHD. The disorder was mild in the majority of the patients and was unrelated to poor outcomes. Nevertheless, hypokalemic MESHD patients required potassium supplements to dampen the risk of arrhythmias HP arrhythmias MESHD.

    Serum SERO calcium as a biomarker of clinical severity and prognosis in patients with coronavirus disease MESHD 2019: a retrospective cross-sectional study

    Authors: Jia-Kui Sun; Wen-Hao Zhang; Lei Zou; Ying Liu; Jing-Jing Li; Xiao-Hua Kan; Lian Dai; Qian-Kun Shi; Shou-Tao Yuan; Wen-Kui Yu; Hong-Yang Xu; Wei Gu; Jian-Wei Qi

    doi:10.21203/rs.3.rs-17575/v1 Date: 2020-03-14 Source: ResearchSquare

    Background: To investigate the correlations between serum SERO calcium and clinical severity and outcomes in patients with coronavirus disease MESHD 2019 (COVID-19).Methods: In this clinical retrospective study, the levels of serum SERO calcium, hormone levels and clinical laboratory parameters of admission were recorded. The clinical severity and outcome variables were also recorded.Results: From February 10 to February 28 2020, 241 patients were enrolled in this study. Of these patients, 180 (74.7%) had hypocalcemia HP hypocalcemia MESHD on admission. The median serum SERO calcium levels were 2.12 (IQR, 2.04-2.20) mmol/L, median parathyroid hormone (PTH) levels were 55.27 (IQR, 42.73-73.15) pg/mL, median 25-hydroxy-vitamin D (VD) levels were 10.20 (IQR, 8.20-12.65) ng/mL. The serum SERO calcium levels were significantly positive correlated with VD levels (P =0.004), whereas negative correlated with PTH levels (P = 0.048). Patients with lower serum SERO calcium levels (especially ≤2.0 mmol/L) had worse clinical parameters, higher incidence of organ injury septic shock MESHD shock HP and higher 28-day mortality. The areas under the receiver operating characteristic curves of multiple organ dysfunction syndrome MESHD, septic shock MESHD shock HP, and 28-day mortality were 0.923 (P <0.001), 0.905 (P =0.001), and 0.929 (P <0.001), respectively. The overall mortality of COVID-19 was 4.1% (10/241), whereas the mortality of critical patients was up to 40.0% (10/25). Conclusions: Serum SERO calcium was associated with clinical severity and prognosis of patients with COVID-19. Hypocalcemia HP Hypocalcemia MESHD may be associated with imbalanced VD MESHD and PTH.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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