Corpus overview


Overview

MeSH Disease

Human Phenotype

Pneumonia (2)

Fever (1)

Cough (1)

Dyspnea (1)

Fatigue (1)


Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Effects of Coronavirus Disease MESHD 2019 (COVID-19) on Maternal, Perinatal and Neonatal Outcomes: a Systematic Review of 266 Pregnancies

    Authors: Juan Juan; Maria M Gil; Zhihui Rong; Yuanzhen Zhang; Huixia Yang; Liona Chiu Yee Poon

    doi:10.1101/2020.05.02.20088484 Date: 2020-05-06 Source: medRxiv

    Objective: To perform a systematic review of available published literature on pregnancies affected by COVID-19 to evaluate the effects of COVID-19 on maternal, perinatal and neonatal outcomes. Methods: We performed a systematic review to evaluate the effects of COVID-19 on pregnancy, perinatal and neonatal outcomes. We conducted a comprehensive literature search using PubMed, EMBASE, Cochrane library, China National Knowledge Infrastructure Database and Wan Fang Data until April 20, 2020 (studies were identified through PubMed alert after April 20, 2020). For the research strategy, combinations of the following keywords and MeSH terms were used: SARS-CoV-2, COVID-19, coronavirus disease MESHD 2019, pregnancy, gestation, maternal, mothers, vertical transmission TRANS, maternal-fetal transmission TRANS, intrauterine transmission TRANS, neonates, infant, delivery. Eligibility criteria included laboratory-confirmed and/or clinically diagnosed COVID-19, patient was pregnant on admission, availability of clinical characteristics, including maternal, perinatal or neonatal outcomes. Exclusion criteria were unpublished reports, unspecified date and location of the study or suspicion of duplicate reporting, and unreported maternal or perinatal outcomes. No language restrictions were applied. Results: We identified several case-reports and case-series but only 19 studies, including a total of 266 pregnant women with COVID-19, met eligibility criteria and were finally included in the review. In the combined data from seven case-series, the maternal age TRANS ranged from 20 to 41 years and the gestational age TRANS on admission ranged from 5 to 41 weeks. The most common symptoms at presentation were fever HP fever MESHD, cough HP, dyspnea HP dyspnea MESHD/ shortness of breath MESHD and fatigue HP fatigue MESHD. The rate of severe pneumonia HP pneumonia MESHD was relatively low, with the majority of the cases requiring intensive care unit admission. Almost all cases from the case-series had positive computer tomography chest findings. There were six and 22 cases that had nucleic-acid testing in vaginal mucus and breast milk MESHD samples, respectively, which were negative for SARS-CoV-2. Only a few cases had spontaneous miscarriage or abortion MESHD. 177 cases had delivered, of which the majority by Cesarean section. The gestational age TRANS at delivery ranged from 28 to 41 weeks. Apgar scores at 1 and 5 minutes HP Apgar scores at 1 and 5 minutes HP ranged from 7 to 10 and 8 to 10, respectively. A few neonates had birthweight less than 2500 grams and over one-third of cases were transferred to neonatal intensive care unit. There was one case each of neonatal asphyxia HP neonatal asphyxia MESHD and neonatal death MESHD. There were 113 neonates that had nucleic-acid testing in throat swab, which was negative for SARS-CoV-2. From the case-reports, two maternal deaths among pregnant women with COVID-19 were reported. Conclusions: The clinical characteristics of pregnant women with COVID-19 are similar to those of nonpregnant adults TRANS with COVID-19. Currently, there is no evidence that pregnant women with COVID-19 are more prone to develop severe pneumonia HP pneumonia MESHD, in comparison to nonpregnant patients. The subject of vertical transmission TRANS of SARS-CoV-2 remains controversial and more data is needed to investigate this possibility. Most importantly, in order to collect meaningful pregnancy and perinatal outcome data, we urge researchers and investigators to reference previously published cases in their publications and to record such reporting when the data of a case is being entered into a registry or several registries.

    Severe Acute Respiratory Syndrome Coronavirus 2(SARS-CoV-2) infection MESHD during late pregnancy: A Report of 18 patients from Wuhan, China

    Authors: Lu Zhang; Lan Dong; Lei Ming; Min Wei; Jun Li; Ruheng Hu; Jing Yang

    doi:10.21203/rs.3.rs-18247/v3 Date: 2020-03-20 Source: ResearchSquare

    Background: Compared with Severe Acute Respiratory Syndrome MESHD(SARS) and Middle East Respiratory Syndrome(MESR), Corona Virus Disease MESHD 2019(COVID-19) spread more rapidly and widely. The population was generally susceptible. However, reports on pregnant women infected with SARS-CoV-2 were very limited. By sharing the clinical characteristics, treatments and outcomes of 18 patients with COVID-19 during late pregnancy, we hoped to provide some references for obstetric treatment and management.Methods: A total of 18 patients with COVID-19 treated in Renmin Hospital of Wuhan University were collected. The epidemiological characteristics, clinical manifestations, laboratory tests, chest CT and pregnancy outcomes were performed for analysis.Results: 1. 18 cases of late pregnancy infected with SARS-CoV-2 pneumonia MESHD pneumonia HP were delivered at 35 + 5 weeks to 41 weeks. According to the clinical classification of COVID-19, 1 case was mild type, 16 cases were ordinary type, and 1 case was severe type. 2. According to Imaging examinations: 15 (83%) cases showed unilateral or bilateral pneumonia HP pneumonia MESHD, 2 (11%) cases had pulmonary infection MESHD with pleural effusion HP pleural effusion MESHD, and 1 (6%) case had no abnormal imaging changes. 8 (44%) cases were positive and 10 (56%) cases were negative for nasopharyngeal-swab tests of SARS-CoV-2. 3. Among the 18 newborns, there were 3 (17%) premature infants, 1 (6%) case of mild asphyxia MESHD, 5 (28%) cases of bacterial pneumonia MESHD pneumonia HP, 1 (6%) case of gastrointestinal bleeding MESHD, 1 (6%) case of necrotizing enteritis MESHD, 2 (11%) cases of hyperbilirubinemia HP hyperbilirubinemia MESHD and 1 (6%) case of diarrhea HP diarrhea MESHD. All the newborns were negative for the first throat swab test of SARS-CoV-2 after birth. 4. Follow-up to Mar 7, 2020, no maternal and neonatal deaths MESHD occurred.Conclusions: The majority of patients in late term pregnancy with COVID-19 were of ordinary type, and they less likely developed into critical pneumonia HP pneumonia MESHD after early isolation and antiviral treatment. Vertical transmission TRANS of SARS-CoV-2 was not detected, but the proportion of neonatal bacterial pneumonia MESHD pneumonia HP was higher than other neonatal diseases in newborns.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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