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MeSH Disease

Human Phenotype

Transmission

Seroprevalence
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    A pattern categorization of CT findings to predict outcome of COVID-19 pneumonia HP pneumonia MESHD

    Authors: Chao Jin; Yan Wang; Carol C. Wu; Huifang Zhao; Ting Liang; Zhe Liu; Zhijie Jian; Runqing Li; Zekun Wang; Fen Li; Jie Zhou; Shubo Cai; Yang Liu; Hao Li; Zhongyi Li; Yukun Liang; Heping Zhou; Xibin Wang; Zhuanqin Ren; Jian Yang

    doi:10.1101/2020.05.19.20107409 Date: 2020-05-25 Source: medRxiv

    Purpose As global healthcare system is overwhelmed by novel coronavirus disease MESHD (COVID-19), early identification of risks of adverse outcomes becomes the key to optimize management and improve survival. This study aimed to provide a CT-based pattern categorization to predict outcome of COVID-19 pneumonia HP pneumonia MESHD. Methods 165 patients with COVID-19 (91 men, 4-89 years) underwent chest CT were retrospectively enrolled. CT findings were categorized as Pattern0 (negative), Pattern1 ( bronchopneumonia MESHD), Pattern2 (organizing pneumonia HP pneumonia MESHD), Pattern3 (progressive organizing pneumonia HP pneumonia MESHD) and Pattern4 (diffuse alveolar damage MESHD). Clinical findings were compared across different categories. Time-dependent progression of CT patterns and correlations with clinical outcomes, i.e. discharge or adverse outcome (admission to ICU, requiring mechanical ventilation, or death MESHD), with pulmonary sequelae (complete absorption or residuals) on CT after discharge were analyzed. Results Of 94 patients with outcome, 81(86.2%) were discharged, 3(3.2%) were admitted to ICU, 4(4.3%) required mechanical ventilation, 6(6.4%) died. 31(38.3%) had complete absorption at median day 37 after symptom-onset TRANS. Significant differences between pattern-categories were found in age TRANS, disease-severity, comorbidity and laboratory results (all P<0.05). Remarkable evolution was observed in Pattern0-2 and Pattern3-4 within 3 and 2 weeks after symptom-onset TRANS, respectively; most of patterns remained thereafter. After controlling for age TRANS, CT pattern significantly correlated with adverse outcomes (Pattern4 vs. Pattern0-3 [reference]; hazard-ratio[95%CI], 18.90[1.91-186.60], P=0.012). CT pattern (Pattern3-4 vs. Pattern0-2 [reference]; 0.26[0.08-0.88], P=0.030) and C-reactive protein (>10 vs. [≤]10mg/L [reference]; 0.31[0.13-0.72], P=0.006) were risk-factors associated with pulmonary residuals. Conclusion CT pattern categorization allied with clinical characteristics within 2 weeks after symptom-onset TRANS would facilitate early prognostic stratification in COVID-19 pneumonia HP pneumonia MESHD.

    Chest CT imaging characteristics of COVID-19 pneumonia HP pneumonia MESHD in preschool children TRANS: a retrospective study

    Authors: Yang Li; Jianghui Cao; Xiaolong Zhang; Guangzhi Liu; Xiaxia Wu; Baolin Wu

    doi:10.21203/rs.3.rs-21851/v2 Date: 2020-04-07 Source: ResearchSquare

    Background: Recently, the World Health Organization has declared the coronavirus disease MESHD 2019 (COVID-19) outbreak a public health emergency of international concern. So far, however, limited data are available for children TRANS. Therefore, we aimed to investigate the clinical and chest CT imaging characteristics of COVID-19 in preschool children TRANS.Methods: From January 26, 2020 to February 20, 2020, the clinical and initial chest CT imaging data of eight preschool children TRANS with laboratory-confirmed COVID-19 from two hospitals were retrospectively collected. The chest CT imaging characteristics, including the distribution, shape, and density of lesions, and the pleural effusion HP pleural effusion MESHD, pleural changes, and enlarged lymph nodes were evaluated. Results: Two cases (25%) were classified as mild type, and they showed no obvious abnormal CT findings or minimal pleural thickening HP pleural thickening MESHD on the right side. Five cases (62.5%) were classified as moderate type. Among these patients, one case showed consolidation located in the subpleural region of the right upper lobe, with thickening in the adjacent pleura; one case showed multiple consolidation and ground-glass opacities with blurry margins; one case displayed bronchial pneumonia HP pneumonia MESHD-like changes in the left upper lobe; and two cases displayed asthmatic bronchitis HP bronchitis MESHD-like changes. One case (12.5%) was classified as critical type and showed bronchial pneumonia MESHD pneumonia HP-like changes in the bilateral lungs, presenting blurred and messy bilateral lung markings MESHD and multiple patchy shadows scattered along the lung markings with blurry margins.Conclusions: The chest CT findings of COVID-19 in preschool children TRANS are atypical and various. Accurate diagnosis requires a comprehensive evaluation of epidemiological, clinical, laboratory and CT imaging data. 

    Pathological Study of the 2019 Novel Coronavirus Disease MESHD (COVID-19) through Post-Mortem Core Biopsies

    Authors: Sufang Tian; Yong Xiong; Huan Liu; Li Niu; Jianchun Guo; Meiyan Liao; Shu-Yuan Xiao

    id:10.20944/preprints202003.0311.v1 Date: 2020-03-20 Source: Preprints.org

    Data on pathologic changes of the 2019 novel coronavirus disease MESHD (COVID-19) are scarce. To gain knowledge about the pathology that may contribute to disease progression and fatality, we performed post-mortem needle core biopsies of lung, liver, and heart in four patients who died of COVID-19 pneumonia HP pneumonia MESHD. The patients’ ages TRANS ranged from 59 to 81, including 3 males TRANS and 1 female TRANS. Each patient had at least one underlying disease, including immunocompromised status ( chronic lymphocytic leukemia MESHD leukemia HP and renal transplantation) or other conditions ( cirrhosis HP cirrhosis MESHD, hypertension HP hypertension MESHD, and diabetes MESHD). Time from disease onset to death ranged from 15 to 52 days. All patients had elevated white blood SERO cell counts, with significant rise toward the end, and all had lymphocytopenia MESHD except for the patient with leukemia HP leukemia MESHD. Histologically, the main findings are in the lungs, including injury to the alveolar MESHD epithelial cells, hyaline membrane formation, and hyperplasia of type II pneumocytes MESHD, all components of diffuse alveolar damage MESHD. Consolidation by fibroblastic proliferation with extracellular matrix and fibrin forming clusters in airspaces is evident. In one patient, the consolidation consists of abundant intra-alveolar neutrophilic infiltration MESHD, consistent with superimposed bacterial bronchopneumonia MESHD. The liver exhibits mild lobular infiltration by small lymphocytes, and centrilobular sinusoidal dilation. Patchy necrosis is also seen. The heart shows only focal mild fibrosis MESHD and mild myocardial hypertrophy MESHD, changes likely related to the underlying conditions. In conclusion, the post-mortem examinations show advanced diffuse alveolar damage MESHD, as well as superimposed bacterial pneumonia HP pneumonia MESHD in some patients. Changes in the liver and heart are likely secondary or related to the underlying diseases.

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