Corpus overview


MeSH Disease

Human Phenotype


    displaying 1 - 7 records in total 7
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    Reversible Lesion of the Corpus Callosum MESHD Associated With COVID-19: A Case Report and Review of Literature MESHD

    Authors: Yagmur Inalkac Gemici; Irem Tasci

    doi:10.21203/ Date: 2020-09-21 Source: ResearchSquare

    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may affect the central nervous system (CNS) and peripheral nervous system (PNS). Major CNS manifestations of SARS-CoV-2 include seizures HP seizures MESHD, meningitis HP meningitis MESHD, meningoencephalitis MESHD, ischemic stroke HP ischemic stroke MESHD, hemorrhagic stroke MESHD stroke HP, anosmia HP anosmia MESHD, hypogeusia MESHD, acute disseminated encephalomyelitis MESHD, hemorrhagic necrotizing encephalopathy MESHD necrotizing encephalopathy HP, and nonfocal phenomena including lethargy HP, agitation HP agitation MESHD, confusion HP confusion MESHD, headache HP headache MESHD, and ataxia HP ataxia MESHD. The reversible splenial lesion syndrome MESHD ( MERS MESHD) was first described in 2004. Although MERS was initially recognized as a benign phenomenon, a second type of MERS was identified in later years, which has a poor prognosis and potentially serious sequela. MERS can be caused by numerous etiologies including viruses. In this report, we present a patient with SARS-CoV-2 who presented with ataxia HP ataxia MESHD and dizziness MESHD as the clinical symptoms of MERS, which is a rare clinical phenomenon and can be caused by numerous etiologies.

    Data Requests and Scenarios for Data Design of Unobserved Events in Corona-related Confusion HP Confusion MESHD Using TEEDA

    Authors: Teruaki Hayashi; Nao Uehara; Daisuke Hase; Yukio Ohsawa

    id:2009.04035v1 Date: 2020-09-08 Source: arXiv

    Due to the global violence of the novel coronavirus, various industries have been affected and the breakdown between systems has been apparent. To understand and overcome the phenomenon related to this unprecedented crisis caused by the coronavirus infectious disease MESHD (COVID-19), the importance of data exchange and sharing across fields has gained social attention. In this study, we use the interactive platform called treasuring every encounter of data affairs (TEEDA) to externalize data requests from data users, which is a tool to exchange not only the information on data that can be provided but also the call for data, what data users want and for what purpose. Further, we analyze the characteristics of missing data in the corona-related confusion HP confusion MESHD stemming from both the data requests and the providable data obtained in the workshop. We also create three scenarios for the data design of unobserved events focusing on variables.

    SARS-CoV-2 Infection Reaches MESHD the Human Nervous System: How?

    Authors: Vladimir N. Uversky; Fatma Elrashdy; Abdullah Aljadawi; Syed Moasfar Ali; Rizwan Hasan Khan; Elrashdy M. Redwan

    id:10.20944/preprints202008.0696.v1 Date: 2020-08-31 Source:

    Without protective and/or therapeutic agents the SARS-CoV-2 infection MESHD known as coronavirus disease MESHD 2019 (COVID-19) is quickly spreading worldwide. It has surprising transmissibility TRANS potential, since it could infect MESHD all ages TRANS, gender TRANS, and human sectors. It attacks respiratory, gastrointestinal, urinary, hepatic, and endovascular systems and can reach the peripheral nervous system (PNS) and central nervous system (CNS) through known and unknown mechanisms. The reports on the neurological manifestations and complications of the SARS-CoV-2 infection MESHD are increasing exponentially. Herein, we enumerate seven candidate routes, which the mature or immature SARS-CoV-2 components could use to reach the CNS and PNS, utilizing the within-body crosstalk between organs. The majority of SARS-CoV-2 infected MESHD patients suffer from some neurological manifestations (e.g., confusion HP confusion MESHD, anosmia HP anosmia MESHD, and ageusia MESHD). It seems that although the mature virus did not reach the CNS or PNS of the majority of patients, its unassembled components and/or the accompanying immune-mediated responses may be responsible for the observed neurological symptoms. The viral particles and/or its components have been specifically documented in endothelial cells of lung, kidney, skin, and CNS. This means that the blood SERO-endothelial-barrier may be considered as the main route for SARS-CoV-2 entry into the nervous system, with the barrier disruption being more logical than barrier permeability, as evidenced by postmortem analyses.

    Level of Knowledge, Attitude and Perception About COVID-19 Pandemic and Infection Control: A Cross-Sectional Study Among Veterinarians in Nigeria MESHD

    Authors: Olubukola Adenubi; Oluwawemimo Adebowale; Abimbola Oloye; Noah Bankole; Hezekiah Adesokan; Oladotun Fadipe; Patience Ayo-Ajayi; Adebayo Akinloye

    id:10.20944/preprints202007.0337.v1 Date: 2020-07-15 Source:

    Coronavirus disease (COVID-19) has caused mankind serious confusion HP confusion MESHD, economic havoc and psychological distress. This study evaluated the level of knowledge, attitude and perception about COVID-19 pandemic, infection control and impact among veterinarians in Nigeria. A cross-sectional online survey was used to collect data from consenting respondents during implementation of lockdown in the country (April 23 - May 31, 2020). Purposive and chain referral sampling techniques were used to recruit 368 respondents from various sectors of the profession. The proportion of respondents surveyed 197/368 (53.5 %) were from the public sector, 35.3 % from private sector, 1.1 % were unemployed and 0.8 % retired. Majority of the respondents were males TRANS (72.8 %), within 30 – 39 years (39.7 %) and had 1 – 10 years work experience. Respondents displayed good level of knowledge about COVID-19 (72.4 % ± 9.9 %, range 44.1-91.2 %), with information mostly derived from TV/Radio (81.5%) and social media (81.0 %). The overall attitude level was poor and various determinants for good attitude among respondents were if they were above 60 years (p = 0.013), possessed postgraduate qualification ( p = 0.031), worked over 30 years post DVM (p = 0.001), had household members between 5 and 10 (p = 0.012), and were resident in states on total lockdown (p = 0.024). There was no correlation between the knowledge level score and respondents’ attitude towards the pandemic (p = 0.12). With increasing rate of COVID-19 transmission TRANS, research data are needed to develop evidence-driven strategies, policies and effective risk mitigations to reduce the pandemic’s adverse impacts.

    Risk of Transmission TRANS of infection MESHD to Healthcare Workers delivering Supportive Care for Coronavirus Pneumonia MESHD Pneumonia HP;A Rapid GRADE Review

    Authors: TK Luqman Arafath; Sandeep S Jubbal; Elakkat D Gireesh; Jyothi Margapuri; Hanumantha Rao Jogu; Hitesh Patni; Tyler Thompson; Arsh Patel; Amirahwaty Abdulla; Suma Menon; Sudheer Penupolu

    doi:10.1101/2020.07.06.20146712 Date: 2020-07-08 Source: medRxiv

    Abstract Background: Avenues of treatment currently implemented for Covid-19 pandemic are largely supportive in nature. Non -availability of an effective antiviral treatment makes supportive care for acute hypoxic respiratory failure MESHD respiratory failure HP is the most crucial intervention. Highly contagious nature of Covid-19 had created stress and confusion HP confusion MESHD among front line Health Care Workers (HCWs) regarding infectious risk of supportive interventions and best preventive strategies. Purpose: To analyze and summarize key evidence from published literature exploring the risk of transmission TRANS of Covid-19 related to common supportive care interventions in hospitalized patients and effectiveness of currently used preventive measures in hospital setting. Data Sources: Curated Covid-19 literature from NCBI Computational Biology Branch ,Embase and Ovid till May 20,2020.Longitudinal and reference search till June 28,2020 Study Selection: Studies pertaining to risk of infection TRANS risk of infection TRANS infection MESHD to HCWs providing standard supportive care of hospitalized Covid-19 mainly focusing on respiratory support interventions.Indirect studies from SARS, MERS MESHD or other ARDS pathology caused by infectious agents based on reference tracking and snow ball search . Clinical, Healthy volunteer and mechanistic studies were included. Two authors independently screened studies for traditional respiratory supportive-care ( Hypoxia MESHD management, ventilatory support and pulmonary toileting) related transmission TRANS of viral or bacterial pneumonia MESHD pneumonia HP to HCWs. Data Extraction: Two authors (TK and SP) independently screened articles and verified for consensus. Quality of studies and level of evidence was assessed using Oxford Center for Evidence Based Medicine (OCEBM) , Newcastle - Ottawa quality assessment Scale for observational studies and Grading of Recommendations Assessment, Development and Evaluation (GRADE) system for grading evidence. Data Synthesis: 21 studies were eligible for inclusion. In 11 mechanistic studies, 7 were manikin based,1 was in the setting of GNB pneumonia MESHD pneumonia HP ,2 were healthy volunteer study and 1 was heterogenous setting.Out of 10 clinical studies ,5 were case controlled and 6 were cohort studies. Risk of corona virus transmission TRANS was significantly high in HCWs performing or assisting endotracheal intubation or contact with respiratory secretion.(Moderate certainty evidence, GRADE B) Safety of nebulization treatment in corona virus pneumonia MESHD pneumonia HP patients are questionable(Low certainty evidence, GRADE C).Very low certainty evidence exist for risk of transmission TRANS with conventional HFNC (GRADE D) and NIV (GRADE D),CPR (GRADE D),Bag and mask ventilation(GRADE D).Moderate certainty evidence exist for protective effect of wearing a multilayered mask, gown , eye protection and formal training for PPE use (GRADE B).Low certainty evidence exist for transmission risk TRANS with bag and mask ventilation, suctioning before and after intubation and prolonged exposure (GRADE C).Certainty of evidence for wearing gloves,post exposure hand washing and wearing N 95 mask is low(GRADE C). Limitations: This study was limited to articles with English abstract. Highly dynamic nature of body of literature related to Covid-19, frequent updates were necessary even during preparation of manuscript and longitudinal search was continued even after finalizing initial search. Due to the heterogeneity and broad nature of the search protocol, quantitative comparisons regarding the effectiveness of included management strategies could not be performed. Direct evidence was limited due to poor quality and non-comparative nature of available Covid-19 reporting. Conclusions: Major risk factors for transmission TRANS of corona virus infection MESHD were, performing or assisting endotracheal intubation and contact with respiratory secretion. Risk of transmission TRANS with HFNC or NIV can be significantly decreased by helmet interface, modified exhalation circuit or placing a properly fitting face mask over patient interface of HFNC. Evidence for risk of transmission TRANS with CPR, suctioning before or after intubation or bag and mask ventilation of very low certainty. Significant protective factors are Formal training for PPE use, consistently wearing mask, gown and eye protection. Primary Funding Source: None Disclosure: None of the authors have any conflict of interest to disclose.

    Cytokine Release Syndrome-Associated Encephalopathy MESHD Encephalopathy HP in Patients with COVID-19

    Authors: Peggy Perrin; Nicolas Collongues; Seyyid Baloglu; Dimitri Bedo; Xavier Bassand; Thomas Lavaux; Gabriela Gautier; Nicolas Keller; Stephane Kremer; Samira Fafi-Kremer; Bruno Moulin; Ilies Benotmane; Sophie Caillard

    id:10.20944/preprints202006.0103.v1 Date: 2020-06-07 Source:

    Severe disease MESHD and uremia MESHD are risk factors for neurological complications of coronavirus disease MESHD-2019 (COVID-19). An in-depth analysis of a case series was conducted to describe the neurological manifestations of patients with COVID-19 and gain pathophysiological insights that may guide clinical decision-making – especially with respect to the cytokine release syndrome (CRS). Extensive clinical, laboratory, and imaging phenotyping was performed in five patients. Neurological presentation included confusion HP confusion MESHD, tremor HP tremor MESHD, cerebellar ataxia MESHD ataxia HP, behavioral alterations, aphasia HP aphasia MESHD, pyramidal syndrome, coma HP coma MESHD, cranial nerve palsy MESHD, dysautonomia MESHD, and central hypothyroidism HP hypothyroidism MESHD. Neurological disturbances MESHD were remarkably accompanied by laboratory evidence of CRS. SARS-CoV-2 was undetectable in the cerebrospinal fluid. Hyperalbuminorachy and increased levels of the astroglial protein S100B were suggestive of blood SERO-brain barrier (BBB) dysfunction. Brain MRI findings comprised evidence of acute leukoencephalitis MESHD (n = 3, of whom one with a hemorrhagic form), cytotoxic edema HP edema MESHD mimicking ischemic stroke HP ischemic stroke MESHD (n = 1), or normal results (n = 2). Treatment with corticosteroids and/or intravenous immunoglobulins was attempted – resulting in rapid recovery from neurological disturbances MESHD in two cases. Patients with COVID-19 can develop neurological manifestations that share clinical, laboratory, and imaging similarities with those of chimeric antigen receptor-T cell-related encephalopathy HP encephalopathy MESHD. The pathophysiological underpinnings appear to involve CRS, endothelial activation, BBB dysfunction, and immune-mediated mechanisms.

    Automatic Detection of Coronavirus Disease MESHD (COVID-19) Using X-ray Images and Deep Convolutional Neural Networks

    Authors: Ali Narin; Ceren Kaya; Ziynet Pamuk

    id:2003.10849v2 Date: 2020-03-24 Source: arXiv

    The 2019 novel coronavirus (COVID-19), with a starting point in China, has spread rapidly among people living in other countries, and is approaching approximately 12,245,417 cases worldwide according to the statistics of European Centre for Disease Prevention and Control. There are a limited number of COVID-19 test kits available in hospitals due to the increasing cases daily. Therefore, it is necessary to implement an automatic detection system as a quick alternative diagnosis option to prevent COVID-19 spreading among people. In this study, three different convolutional neural network based models (ResNet50, InceptionV3 and Inception-ResNetV2) have been proposed for the detection of coronavirus pneumonia infected MESHD pneumonia HP infected patient using chest X-ray radiographs. ROC analyses and confusion HP confusion MESHD matrices by these three models are given and analyzed using 5-fold cross validation. Considering the performance SERO results obtained, it is seen that the pre-trained ResNet50 model provides the highest classification performance SERO with 98% accuracy among other two proposed models (97% accuracy for InceptionV3 and 87% accuracy for Inception-ResNetV2).

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MeSH Disease
Human Phenotype

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