Corpus overview


Overview

MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    Neurological Complications MESHD and Noninvasive Multimodal Neuromonitoring in Critically ill MESHD COVID-19 Patients

    Authors: Denise Battaglini; Gregorio Santori; Karthikka Chandraptham; Francesca Iannuzzi; Matilde Bastianello; Fabio Tarantino; Lorenzo Ball; Daniele Roberto Giacobbe; Antonio Vena; Matteo Bassetti; Patricia Rieken Macedo Rocco; Nicolò Patroniti; Iole Brunetti; Paolo Pelosi; Chiara Robba

    doi:10.21203/rs.3.rs-57910/v1 Date: 2020-08-12 Source: ResearchSquare

    Background: The incidence and clinical presentation of neurological manifestations of coronavirus disease MESHD 2019 (COVID-19) remain unclear. No data regarding the use of neuromonitoring tools in this group of patients are available. Methods: This is a retrospective study of prospectively collected data. The primary aim was to assess the incidence and type of neurological complications in critically ill COVID-19 patients and their effect on survival, as well as on hospital and intensive care unit (ICU) length-of-stay. The secondary aim was to describe cerebral hemodynamic changes detected by noninvasive neuromonitoring modalities such as transcranial doppler (TCD), optic nerve sheath diameter (ONSD), and pupillometry. Results: Ninety-four patients with COVID-19 receiving mechanical ventilation and admitted to an ICU from February 28 to June 30, 2020, were included in this study. Fifty-three patients underwent noninvasive neuromonitoring. Neurological complications MESHD were detected in 47/94 patients (50%), with delirium HP delirium MESHD as the most common manifestation. Patients with neurological complications MESHD, compared to those without, had longer hospital (36.8±25.1 vs. 19.4±16.9 days, p <0.001) and ICU (31.5±22.6 vs. 11.5±10.1 days, p <0.001) stay. The duration of mechanical ventilation was independently associated with risk of developing neurological complications MESHD (OR 1.100, 95%CI 1.046-1.175, p=0.001). Patients with increased intracranial pressure HP (ICP) measured by ONSD (19% of the overall population) had longer ICU stays. Conclusions: In conclusion, neurological complications MESHD are common in critically ill patients with COVID-19 receiving invasive mechanical ventilation and are associated with prolonged ICU length-of-stay. Multimodal noninvasive neuromonitoring systems are useful tools for early detection of cerebrovascular changes in COVID-19. Registration number: 163/2020

    Frailty and mortality in hospitalized older adults TRANS with COVID-19: retrospective observational study

    Authors: Robert De Smet; Bea Mellaerts; Hannelore Vandewinckele; Peter Lybeert; Eric Frans; Sara Ombelet; Wim Lemahieu; Rolf Symons; Erwin Ho; Johan Frans; Annick Smismans; Michael R Laurent

    doi:10.1101/2020.05.26.20113480 Date: 2020-05-27 Source: medRxiv

    Background: Older adults TRANS with coronavirus disease MESHD 2019 (COVID-19) face an increased risk of adverse health outcomes including mortality. Ethical guidelines consider allocation of limited resources based on likelihood of survival, frailty, co-morbidities and age TRANS. However, the association of frailty with clinical outcomes in older COVID-19 patients remains unclear. Objectives: To determine the association between frailty and short-term mortality in older adults TRANS hospitalized for COVID-19. Design: Retrospective single-center observational study. Setting and participants: N = 81 patients with COVID-19 confirmed by reverse-transcriptase polymerase chain reaction (RT-PCR), at the Geriatrics department of Imelda general hospital, Belgium. Measurements: Frailty was graded according to the Rockwood Clinical Frailty Scale (CFS). Demographic, biochemical and radiological variables, co-morbidities, symptoms and treatment were extracted from electronic medical records. Results: Participants (N = 48 women, 59%) had a median age TRANS of 85 years (range 65 - 97 years), median CFS score of 7 (range 2 - 9), and 42 (52%) were long-term care residents. Within six weeks, eighteen patients died. Mortality was significantly but weakly associated with age TRANS (Spearman r = 0.241, P = 0.03) and CFS score (r = 0.282, P = 0.011), baseline lactate dehydrogenase (LDH) (r = 0.301, P = 0.009), lymphocyte count (r = -0.262, P = 0.02) and RT-PCR Ct value (r TRANS = -0.285, P = 0.015). Mortality was not associated with long-term care residence, dementia HP dementia MESHD, delirium HP delirium MESHD or polypharmacy. In multivariable logistic regression analyses, CFS, LDH and RT-PCR Ct values (but not age TRANS) remained independently associated with mortality. Both age TRANS and frailty had poor specificity to predict survival. A multivariable model combining age TRANS, CFS, LDH and viral load significantly predicted survival. Conclusions and implications: Although their prognosis is worse, even the oldest and most severely frail patients may benefit from hospitalization for COVID-19, if sufficient resources are available.

    Neurological Manifestations and Complications of COVID-19: A Literature Review

    Authors: Imran Ahmad; Farooq Azam Rathore

    id:10.20944/preprints202004.0453.v1 Date: 2020-04-25 Source: Preprints.org

    The Coronavirus disease MESHD due to SARS-CoV-2 emerged in Wuhan city, China in December 2019 and rapidly spread more than 200 countries as a global health pandemic. There are more 3 million confirmed cases TRANS and around 207,000 fatalities. The primary manifestation is respiratory and cardiac but neurological manifestations are being reported in the literature as case reports and case series. The most common reported symptoms to include headache HP headache MESHD and dizziness MESHD followed by encephalopathy HP encephalopathy MESHD and delirium HP delirium MESHD. Among the complications noted are Cerebrovascular accident MESHD, Guillian barre syndrome, acute transverse myelitis MESHD myelitis HP, and acute encephalitis MESHD encephalitis HP. The most common peripheral manifestation was hyposmia HP. It is further noted that sometimes the neurological manifestations can precede the typical features like fever HP fever MESHD and cough HP cough MESHD and later on typical manifestations develop in these patients. Hence a high index of suspicion is required for timely diagnosis and isolation of cases to prevent the spread in neurology wards. We present a narrative review of the neurological manifestations and complications of COVID-19. Our aim is to update the neurologists and physicians working with suspected cases of COVID-19 about the possible neurological presentations and the probable neurological complications resulting from this novel virus infection MESHD.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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