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MeSH Disease

Human Phenotype

Transmission

Seroprevalence

There are no seroprevalence terms in the subcorpus

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    The Incidence of Pulmonary Thromboembolism in Critically MESHD Thromboembolism HP in Critically Ill Patients With COVID-19: A Systematic Review, Meta-Analysis and Meta-Regression of Observational Studies

    Authors: Jun Jie Ng; Zhen Chang Liang; Andrew MTL Choong

    doi:10.21203/rs.3.rs-74260/v1 Date: 2020-09-08 Source: ResearchSquare

    Purpose Coronavirus disease MESHD 2019 (COVID-19) infection is known to be associated with a hypercoagulable and prothrombotic state, especially in critically ill MESHD patients. Several observational studies have reported the incidence of thromboembolic MESHD events such as pulmonary thromboembolism MESHD thromboembolism HP ( PTE MESHD). We performed a meta-analysis to estimate the weighted average incidence of PTE MESHD in critically ill COVID-19 patients who are admitted to the intensive care unit.Methods We searched MEDLINE via PubMed, Embase and Web of Science for relevant studies from 31 December 2019 till 15 Aug 2020 onwards using the search terms “coronavirus”, “COVID-19”, “SARS-CoV-2”, “2019-nCoV”, “thrombus”, “thrombo*”, “ embolus MESHD” and “emboli*”. We included prospective and retrospective observational studies that reported the incidence of PTE MESHD in critically ill COVID-19 patients who required treatment in the intensive care unit. We identified 14 studies after two phases of screening and extracted data related to study characteristics, patient demographics and the incidence of PTE MESHD. Risk of bias was assessed by using the ROBINS-I tool. Statistical analysis was performed with R 3.6.3.Results We included 14 studies with a total of 1182 patients in this study. Almost 100% of patients in this meta-analysis received at least prophylactic anticoagulation. The weighted average incidence of PTE MESHD was 11.09% (95% CI 7.72% to 15.69%, I2 = 78%, Cochran’s Q test P < 0.01). We performed univariate and multivariate meta-regression which identified the proportion of males TRANS as a significant source of heterogeneity (P = 0.03, 95% CI 0.00 to -0.09)Conclusion This is the only study that had specifically reported the weighted average incidence of PTE MESHD in critically ill COVID-19 patients using meta-analytic techniques. The weighted average incidence of PTE MESHD remains high even after prophylactic anticoagulation. This study is limited by incomplete data from included studies. More studies are needed to determine the optimal anticoagulation strategy in critically ill COVID-19 patients.

    Characteristics of Ischemic Stroke HP Stroke MESHD in COVID-19: A Need for Early Detection and Management

    Authors: Dinesh V. Jillella; Nicholas J. Janocko; Fadi Nahab; Karima Benameur; James G. Greene; Wendy L. Wright; Mahmoud Obideen; Srikant Rangaraju

    doi:10.1101/2020.05.25.20111047 Date: 2020-05-26 Source: medRxiv

    Objective: In the setting of the Coronavirus Disease MESHD 2019 (COVID-19) global pandemic caused by SARS-CoV-2, a potential association of this disease with stroke HP stroke MESHD has been suggested. We aimed to describe the characteristics of patients who were admitted with COVID-19 and had an acute ischemic stroke HP ischemic stroke MESHD ( AIS MESHD). Methods: This is a case series of PCR-confirmed COVID-19 patients with ischemic stroke HP ischemic stroke MESHD admitted to an academic health system in metropolitan Atlanta (USA) between March 24th,2020, and May 5th, 2020. Demographic, clinical, and radiographic characteristics were described. Results: Of 124 ischemic stroke HP ischemic stroke MESHD stroke MESHD patients admitted during this study period, 8 (6.5%) were also diagnosed with COVID-19. The mean age TRANS of patients was 64.3 +/- 6.5 years, 5 (62.5%) male TRANS, mean time from last-normal was 4.8 days [SD 4.8], and none received acute reperfusion therapy. All 8 patients had at least one stroke HP stroke MESHD-associated co-morbidity. The predominant pattern of ischemic stroke HP ischemic stroke MESHD was embolic MESHD; 3 were explained by atrial fibrillation HP atrial fibrillation MESHD while 5 (62.5%) were cryptogenic. In contrast, cryptogenic strokes HP strokes MESHD were seen in 20 (16.1%) of 124 total stroke HP stroke MESHD admissions during this time. Conclusions: In our case series, ischemic stroke HP ischemic stroke MESHD affected COVID-19 patients with traditional stroke HP stroke MESHD risk factors with an age TRANS of stroke HP stroke MESHD presentation typically seen in non-COVID populations. We observed a predominantly embolic pattern of stroke MESHD stroke HP with a higher than expected rate of cryptogenic strokes HP strokes MESHD and with a prolonged median time to presentation and symptom recognition limiting the use of acute reperfusion treatments. These results highlight the need for increased community awareness, early identification, and management of AIS in COVID-19 patients.

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MeSH Disease
Human Phenotype
Transmission
Seroprevalence


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