Corpus overview


Overview

MeSH Disease

Human Phenotype

Encephalitis (3)

Stroke (2)

Pneumonia (1)

Fever (1)

Cough (1)


Transmission

Seroprevalence
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    Non-permissive SARS-CoV-2 infection MESHD of neural cells in the developing human brain and neurospheres

    Authors: Ismael C. Gomes; Carla Ver&iacutessimo; Jairo R Temerozo; Helena L. Borges; Thiago M. L. Souza; Jeff Green; Julia Schaletzky; Ahmet Yildiz; Louise Rowntree; Thi Nguyen; Katherine Kedzierska; Denise Doolan; Carola Vinuesa; Matthew Cook; Nicholas Coatsworth; Paul Myles; Florian Kurth; Leif Sander; Russell Gruen; Graham Mann; Amee George; Elizabeth Gardiner; Ian Cockburn; Bala Pesala; Debojyoti Chakraborty; Souvik Maiti

    doi:10.1101/2020.09.11.293951 Date: 2020-09-14 Source: bioRxiv

    Coronavirus disease MESHD 2019 (COVID-19) was initially described as a viral infection of the respiratory tract HP. It is now known, however, that many other biological systems are affected, including the central nervous system (CNS). Neurological manifestations such as stroke HP stroke MESHD, encephalitis HP encephalitis MESHD, and psychiatric MESHD conditions have been reported in COVID-19 patients, but its neurotropic potential is still debated. Here, we investigate the presence of SARS-CoV-2 in the brain from an infant patient deceased from COVID-19. The susceptibility to virus infection MESHD was compatible with the expression levels of viral receptor ACE2, which is increased in the ChP in comparison to other brain areas. To better comprehend the dynamics of the viral infection in neural cells, we exposed human neurospheres to SARS-CoV-2. Similarly to the human tissue, we found viral RNA in neurospheres, although viral particles in the culture supernatant were not infective. Based on our observations in vivo and in vitro, we hypothesize that SARS-CoV-2 does not generate productive infection in developing neural cells and that infection of ChP weakens the blood SERO-cerebrospinal fluid barrier allowing viruses, immune cells, and cytokines to access the CNS, causing neural damage in the young brain.

    Neurological Involvement of Coronavirus Disease MESHD 2019: A Systematic Review

    Authors: Malik Ghannam; Qasem Alshaer; Mustafa Al-Chalabi; Lara Zakarna; Jetter Robertson; Georgios Manousakis

    doi:10.21203/rs.3.rs-31183/v1 Date: 2020-05-23 Source: ResearchSquare

    Background: In December 2019, unexplained cases of pneumonia HP pneumonia MESHD emerged in Wuhan, China, which were found to be secondary to the novel coronavirus SARS-CoV-2. On March 11, 2020, the WHO declared the Coronavirus Disease MESHD 2019 (COVID-2019) outbreak, a pandemic. Although the most common presentations of COVID-19 are fever HP fever MESHD, cough HP cough MESHD and shortness of breath MESHD, several clinical observations indicate that COVID-19 does affect the central and peripheral nervous system.  Methods: We conducted a systematic literature search from December 01, 2019 to May 14, 2020 using multiple combinations of keywords from PubMed and Ovid Medline databases according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We included articles with cases of COVID-19 that were evident for neurological involvement.  Results: We were able to identify 82 cases of COVID-19 with neurological complications. The mean age TRANS was 62.28 years. 37.8% of the patients were women (n = 31). 48.8% of the patients (n=40) had cerebrovascular insults, 28% (n=23) had neuromuscular disorders MESHD, 18.3% of the patients (n=15) had encephalitis HP encephalitis MESHD or encephalopathy HP encephalopathy MESHD, and 2.4% (n=2) presented with status epilepticus HP status epilepticus MESHD. Conclusions: Neurological manifestations of COVID-19 infection MESHD are not rare, especially large vessel stroke HP stroke MESHD, Guillain barre syndrome MESHD and meningoencephalitis MESHD. Moving forward, further studies are needed to clarify the prevalence SERO of the neurological complications of COVID-19, investigate their biological backgrounds, and test treatment options. Physicians should be cautious not to overlook other neurological diagnoses that can mimic COVID-19 during the pandemic.

    Ageusia and Anosmia MESHD Anosmia HP, a Common Aign of COVID-19? A Case Series from Four Countries

    Authors: Jair Vargas-Gandica; Daniel Winter; Rainer Schnippe; Andrea G. Rodriguez-Morales; Johana Mondragon; Juan Pablo Escalera-Antezana; María del Pilar Trelles-Thorne; D. Katterine Bonilla-Aldana; Alfonso J. Rodriguez-Morales; Alberto Paniz-Mondolfi

    id:10.20944/preprints202005.0327.v1 Date: 2020-05-20 Source: Preprints.org

    Over the course of the pandemic due to the severe acute respiratory syndrome coronavirus 2 MESHD (SARS-CoV-2), multiple new clinical manifestations, as the consequence of the tropism of the virus, have been recognized. That includes now the neurological manifestations and conditions, such as headache HP headache MESHD, encephalitis HP encephalitis MESHD, as well as olfactory and taste disorders MESHD. We present a series of ten cases of RT-PCR confirmed SARS-CoV-2 infected MESHD patients diagnosed with viral-associated olfactory and taste loss MESHD from four different countries.

The ZB MED preprint Viewer preVIEW includes all COVID-19 related preprints from medRxiv and bioRxiv, from ChemRxiv, from ResearchSquare, from arXiv and from Preprints.org and is updated on a daily basis (7am CET/CEST).
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